DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IRS2 and irs2b

DIOPT Version :9

Sequence 1:	NP_003740.2	Gene:	IRS2 / 8660	HGNCID:	6126	Length:	1338	Species:	Homo sapiens
Sequence 2:	XP_700746.4	Gene:	irs2b / 572001	ZFINID:	ZDB-GENE-081104-462	Length:	1062	Species:	Danio rerio

Alignment Length:	1365	Identity:	653/1365 - (47%)
Similarity:	783/1365 - (57%)	Gaps:	332/1365 - (24%)

- Green bases have known domain annotations that are detailed below.

Human     1 MASPPRHGPPGPASGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEATAGGG 65
            |||||   |.|     |..:::....||:.|:|||||||||||||||||||.|..|
Zfish     3 MASPP---PTG-----GQLISDMTVKNNNHVKKCGYLRKQKHGHKRFFVLREPSDG--------- 50

Human    66 SAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYFAVAAENEQ 130
               ...|||||||||||::|:.| ||||.||.|||||||||||||:||||||||||||||.||||
Zfish    51 ---SRARLEYYESEKKWKNKSAA-KRVIPLDSCLNINKRADAKHKHLIALYTKDEYFAVATENEQ 111

Human   131 EQEGWYRALTDLVSEGRAAAGDAPPAAAPAASCSASLPGALGGSAGAAGAEDSYGLVAPATAAYR 195
            |||.|:..||||::||:.:.|.       |::.::||.|.         .|.:||::.|.||||:
Zfish   112 EQEDWFTVLTDLMNEGKVSDGS-------ASNSASSLVGF---------DEANYGVITPVTAAYK 160

Human   196 EVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMNIRRCGHSDSFFFIEVG 260
            ||||||||.||||||:|||||||||||:|||.|||||.|..||.|||||||||||||||||||||
Zfish   161 EVWQVNLKSKGLGQSRNLTGVYRLCLSSRTISFVKLNTENASVILQLMNIRRCGHSDSFFFIEVG 225

Human   261 RSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRH 325
            |||..||||||||||||||||||||||||||||:||:.||||||||||||   |:||||| .|||
Zfish   226 RSASIGPGELWMQADDSVVAQNIHETILEAMKAMKEMSEFRPRSKSQSSG---TNPISVP-TRRH 286

Human   326 HHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCRVRTASEGDGGAAAGAAAAGARPVSVAGSPL 390
            .:  |||||||||.|||||||:|||.|..|.:|||:||||||||               ..|||:
Zfish   287 FN--NLPPSQTGLPRRSRTDSMAATSPVTKLTSCRIRTASEGDG---------------TLGSPI 334

Human   391 SPGPVRAPLSRSHTLSGGCGGRGSKVALLPAGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHG 455
            |||..|..||||:|::       ::........:||||:||||||:|||.:|.||.|||.||.
Zfish   335 SPGVNRTHLSRSNTVT-------ARPCRTFESSSLQHSKSMSMPVSHSPLSAASPVSLSCSSN-- 390

Human   456 SGSYPPPPGPHPPLPHPLHHGPGQRPSSGSASASGSPSDPGFMSLDEYGSSPGDLR-AFCSHRSN 519
                             :..||  ||||.:||.||||||.||:|.||.||||||:| ...::|||
Zfish   391 -----------------IEGGP--RPSSCTASISGSPSDAGFISCDECGSSPGDVRHLLAANRSN 436

Human   520 TPESIAETPPARDGGGGGEFYGYMTMDRPLSHCGRSYRRVSGDAAQDLDRGLRKRTYSLTTPARQ 584
            ||||:|:|||:::   |.:.||||.|:||.|...|..|....:...||::..||||:|||.|.::
Zfish   437 TPESLADTPPSQE---GSDLYGYMIMERPSSFGQRGIRAAGEEILGDLEKAYRKRTHSLTMPYQK 498

Human   585 RPVPQPSSASLDEYTLMRATF--SGSAGRLCPSCPASSPKVAYHPYPEDYGDIEIGS-HRSSSSN 646
            |...|.||||||||||||||:  :|.:||   |...:||||.   |||||||||||| .:|||.|
Zfish   499 RVPSQVSSASLDEYTLMRATYTTAGHSGR---SSHTASPKVT---YPEDYGDIEIGSLLKSSSGN 557

Human   647 LGADDGYMPMTPGAALAGSGSGSCRSDDYMPMSPASVSAPKQILQPRAAAAAAAAVPSAGPAGPA 711
            :| ||||||||||.|..|.     ::|:|||||...|||||||:.|
Zfish   558 IG-DDGYMPMTPGVAPQGG-----KADNYMPMSSMCVSAPKQIINP------------------- 597

Human   712 PTSAAGRTFPAS-GGGYKASSPAESSPEDSGYMRMWCGSKLSMEHADGKLLPNGDYLNVSPSDAV 775
                  ||.|.: ..||:.|||:..|.||||||||.||||.|::.:||| :.||:|||:||.|:|
Zfish   598 ------RTHPLTIANGYRTSSPSSCSLEDSGYMRMLCGSKFSIDSSDGK-MTNGEYLNMSPVDSV 655

Human   776 TTGTPPDFFSAALHPGGEPLRGVPGCCYSSLPRSYKAPYTC--GGDSDQYVLMSSPVGRILEEER 838
               ||||::   |.|....||.:..  ::||||.:| |...  ..|:||||:|:....:|:||.
Zfish   656 ---TPPDYY---LSPESPRLRQLHS--FNSLPRCHK-PQQMQKDADNDQYVVMNPQSHKIIEES- 710

Human   839 LEPQATPGPSQAASAFGAGPTQPPHPVVPSPVRPSGGRPEGFLGQRGRAVRPTRLSLEGLPSLPS 903
                                .:...|..|||:|.|  |.:..: .|.|..|||||||:.|.:|||
Zfish   711 --------------------VKTASPPAPSPLRQS--RTDNLI-LRHRISRPTRLSLDTLRTLPS 752

Human   904 MHEYPLPPEPKSPGEYINIDFGEPGARLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSD 968
            |:|:|.|.||||||||||||||......:||            |..|..||||||||     .:|
Zfish   753 MNEHPNPSEPKSPGEYINIDFGHVAESCTPP------------STASFESPASSLGS-----FAD 800

Human   969 SRQRSPLSDYMNLDFSSPKSPKPGAPSGHPVGSLDGLLSPEASSPYPPLPPRPSASPSSSLQPPP 1033
            .| .|||||||||:.|| :|||.|                             :|:||..|:|.|
Zfish   801 QR-TSPLSDYMNLNVSS-QSPKSG-----------------------------NAAPSDRLEPLP 834

Human  1034 ---------PPPAPGELY----RLPPASAVATAQGPGAASSLSSDTGDNGDYTEMAFGVAATPPQ 1085
                     ......|.|    :|.||..|..|:               .|||||.|||:|:.|
Zfish   835 ECTSCPTHTEEEEEDERYQCKAQLAPAGPVDKAK---------------DDYTEMTFGVSASSP- 883

Human  1086 PIAAPPKP-EAARVASPTSGVKRLSLMEQVS--GVEAFLQASQP---PDPHRGAKVIRADPQGGR 1144
                ||:| |..:..||:|.::||::.|...  .|||||..:.|   .||.||||||||||| ||
Zfish   884 ----PPQPSEGGQTISPSSCLQRLTVDENAGAPAVEAFLLHAAPLALVDPDRGAKVIRADPQ-GR 943

Human  1145 RRHSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGVGVGPGGGDEPPTSPRQLQP 1209
            |||||||||||||||||.|||||:.:||.||||||||:      .|..|.|..:|
Zfish   944 RRHSSETFSSTTTVTPVFPSFAHDTRRHGSASVENVSV------SVRNGEGSDEE---------- 992

Human  1210 APPLAPQGRPWTPGQPGGLVGCPGSGGSPMRRETSAGFQNGLNYIAIDVREEPGLPPQPQPPPPP 1274
                                     ..|||.|||||||||||||||:::.:
Zfish   993 -------------------------YNSPMCRETSAGFQNGLNYIALNLMD-------------- 1018

Human  1275 LPQPGDKSSWGRTRSLGGLISAVG-VGSTGGGCGGPGPGALPPANTYASIDFLSHHLKEATIVKE 1338
                            |||.|... |......|...|...: ..:.|||:.|..    .||.||:
Zfish  1019 ----------------GGLASCDSLVRFKAASCCKEGINGI-HTSPYASLGFKD----TATTVKD 1062

Human 1339 1338
Zfish 1063 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IRS2	NP_003740.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		10/29 (34%)
		PH_IRS	31..147	CDD:269959	81/115 (70%)
		PH	31..144	CDD:278594	80/112 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..72		5/22 (23%)
		PTB_IRS	194..297	CDD:269915	90/102 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	303..411		61/107 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..537		55/109 (50%)
		YXXM motif 1	540..543		2/2 (100%)
		YXXM motif 2	598..601		2/2 (100%)
		YXXM motif 3	653..656		2/2 (100%)
		YXXM motif 4	675..678		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	703..739		9/36 (25%)
		YXXM motif 5	742..745		2/2 (100%)
		YXXM motif 6	823..826		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	840..1101		94/274 (34%)
		YXXM motif 7	1072..1075		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1296		74/177 (42%)
irs2b	XP_700746.4	PH_IRS	25..128	CDD:269959	81/115 (70%)
		PH	25..124	CDD:278594	79/111 (71%)
		PTB_IRS	159..261	CDD:269915	89/101 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194338095
Domainoid	1	1.000	609	1.000	Domainoid score	I1649
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2778
Inparanoid	1	1.050	964	1.000	Inparanoid score	I2477
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39151
OrthoDB	1	1.010	-	-		D121380at7742
OrthoFinder	1	1.000	-	-		FOG0001178
OrthoInspector	1	1.000	-	-		otm27950
orthoMCL	1	0.900	-	-		OOG6_105771
Panther	1	1.100	-	-	LDO	PTHR10614
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1499
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.410