DRSC/TRiP Functional Genomics Resources

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Protein Alignment IRS2 and irs2a

DIOPT Version :9

Sequence 1:NP_003740.2 Gene:IRS2 / 8660 HGNCID:6126 Length:1338 Species:Homo sapiens
Sequence 2:XP_021322439.1 Gene:irs2a / 393285 ZFINID:ZDB-GENE-040426-975 Length:1086 Species:Danio rerio


Alignment Length:1347 Identity:620/1347 - (46%)
Similarity:748/1347 - (55%) Gaps:326/1347 - (24%)


- Green bases have known domain annotations that are detailed below.


Human     1 MASPPRHGPPGPASGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEATAGGG 65
            |||||..|        ||:|:|:||.:::::||.|||:||||||:|:|||:....|         
Zfish     1 MASPPLKG--------GPSLSNSNNIHSNNIRKHGYLKKQKHGHRRYFVLKDTSDG--------- 48

Human    66 SAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYFAVAAENEQ 130
               .|.||||:|:||||::|: ||||||.||.||:|||||||||:||||||||||||||||||||
Zfish    49 ---LPARLEYHENEKKWKNKS-APKRVIFLDSCLSINKRADAKHRYLIALYTKDEYFAVAAENEQ 109

Human   131 EQEGWYRALTDLVSEGRAAAGDAPPAAAPAASCSASLPGALGGSAGAAGAEDSYGLVAPATAAYR 195
            |||.||..|.||:|:|:.              |.:::..:.....|.  .|.:||::.|..|||:
Zfish   110 EQESWYGDLADLLSKGKV--------------CDSTVSNSASSLVGF--DEGNYGMITPVNAAYK 158

Human   196 EVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMNIRRCGHSDSFFFIEVG 260
            ||||||||.||||||:|:|||:||||::|||.|||||.|..||||||||||||||||||||||||
Zfish   159 EVWQVNLKAKGLGQSRNITGVFRLCLTSRTISFVKLNSEVASVTLQLMNIRRCGHSDSFFFIEVG 223

Human   261 RSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRH 325
            |||.|||||||||||||||||||||||||||||:|||.|||||||||||||   :|||||..|  
Zfish   224 RSASTGPGELWMQADDSVVAQNIHETILEAMKAMKELSEFRPRSKSQSSGS---NPISVPTRR-- 283

Human   326 HHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCRVRTASEGDGGAAAGAAAAGARPVSVA---- 386
             :|.|||||||||||||||||.|||.|..|.||||:||||||:|        ...|||||:    
Zfish   284 -NLNNLPPSQTGLVRRSRTDSTAATSPVTKFSSCRIRTASEGEG--------TMIRPVSVSVSEN 339

Human   387 GSPLSPGPVRAPLSRSHTLSGGCGGRGSKVALLPAGGALQHSRSMSMPVAHSPPAATSPGSLSSS 451
            |||::.|  |..:|||:|:|.||  |.|:.:|      |.|||||||.:.||||:..||.||||.
Zfish   340 GSPMTVG--RHHMSRSNTVSVGC--RTSEPSL------LNHSRSMSMTMYHSPPSVVSPLSLSSI 394

Human   452 SGHGSGSYPPPPGPHPPLPHPLHHGPGQRPSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFCSH 516
            |.:||.|                 ....||||.|.|.||||:|.||::.::|.|||||:|...::
Zfish   395 SMNGSIS-----------------NKAHRPSSCSGSVSGSPNDFGFLTCEDYSSSPGDVRYNLAN 442

Human   517 RSNTPESIAETPPARDGGGGGEFYGYMTMDRPLSHCGRSYRRVSGDAAQDLD-RGLRKRTYSLTT 580
            ||:||.|::.|||.|:   ..|.:.||.||||.:.   |..:.|.|.   || ...|||||||||
Zfish   443 RSDTPSSLSSTPPLRE---TSELHSYMVMDRPSNF---SQNKTSRDM---LDVETYRKRTYSLTT 498

Human   581 PARQRPVPQPSSASLDEYTLMRATFSGSAGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSS 645
            |.:|....|.||||||||.||||..|.| ||   |..::|||::   |||||||||||    |:.
Zfish   499 PRQQMAHSQLSSASLDEYMLMRAANSHS-GR---STNSASPKLS---YPEDYGDIEIG----SNC 552

Human   646 NLGADDGYMPMTPGAALAGSGSGSCRSDDYMPMSPASVSAPKQILQPRAAAAAAAAVPSAGPAGP 710
            |:| ||||||||||.|     ..|.::|.||||||.||||||||:.||           :.|..|
Zfish   553 NVG-DDGYMPMTPGMA-----PQSAKNDHYMPMSPMSVSAPKQIINPR-----------SHPQSP 600

Human   711 APTSAAGRTFPASGGGYKASSPAESSPEDSGYMRMWCGSKLSMEHADGKLLPNGDYLNVSPSDAV 775
                         |.|..|:||:..|.||||||:||.|||.|:|.:||| ..||:|:|:||.|..
Zfish   601 -------------GSGCTANSPSSGSLEDSGYMKMWSGSKFSLESSDGK-AANGEYVNMSPVDTS 651

Human   776 TTGTPPDFFSAALHPGGEPLRGVPGCCYSSLPRSYKAPYTCGGDSDQYVLMSSPVGRILEEERLE 840
            .:.|||::|.....|...|       ..:...|..|.......|.:|||.||             
Zfish   652 ISPTPPEYFMGPCEPTQRP-------SPTQSIRFNKQQVPKRVDDNQYVFMS------------- 696

Human   841 PQATPGPSQAASAFGAGPTQPPHPVVPSPVRPSGGRPEGFLGQRGRAVRPTRLSLEGLPSLPSMH 905
            ||......:|.|.....|..               ||: .:.||.:..||.||||:.|..||.|.
Zfish   697 PQNQNQTEEANSVSSLPPLY---------------RPD-VMAQRSKVNRPNRLSLDALRMLPRMT 745

Human   906 EYPLPPEPKSPGEYINIDFGEPGARLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSDSR 970
            |:|||.|||||||||||||.             .|:..||.|:::..:.||         .|..|
Zfish   746 EHPLPCEPKSPGEYINIDFA-------------AATQYSSQSMVTVENQAS---------LSSLR 788

Human   971 QRSPLSDYMNLDFSSPKSP--KPGAPSGHPVGSLDGLLSPEASSPYPPLPPRPSASPSSSLQPPP 1033
            |.|||||||||:.||..|.  :..:|       ||||  ||.:.    .||.......:..:..|
Zfish   789 QGSPLSDYMNLNQSSHSSKLCEMSSP-------LDGL--PELAE----CPPDDGTCFLNEQRNLP 840

Human  1034 PPPAPGELYRLPPASAVATAQGPGAASSLSSDTGDNGDYTEMAFGVAATPPQPIAAPPKPEAARV 1098
            .|...|:                             |:||||:|...:...|..|:         
Zfish   841 CPSVSGK-----------------------------GNYTEMSFNSGSLENQKSAS--------- 867

Human  1099 ASPTSGVKRLSLMEQ-VS-GVEAFLQASQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPV 1161
            .||||.|:||:|..| || |:.|||.|:...||:.|||||||||| ||||||||||||||||.||
Zfish   868 VSPTSRVQRLNLGNQGVSKGIGAFLLAASSVDPNGGAKVIRADPQ-GRRRHSSETFSSTTTVAPV 931

Human  1162 SPSFAHNPKRHNSASVENVSLRKSSEGGVGVGPGGGDEPPTSPRQLQPAPPLAPQGRPWTPGQPG 1226
            .||||||.|||:||||||:|:|.|.         |.||                           
Zfish   932 FPSFAHNVKRHSSASVENISVRSSE---------GSDE--------------------------- 960

Human  1227 GLVGCPGSGGSPMRRETSAGFQNGLNYIAIDVREEPGLPPQPQPPPPPLPQPGDKSSWGRTRSLG 1291
                   ...|||.:|.|||:||||||||:::.|                    |...|...:| 
Zfish   961 -------EYESPMCQEMSAGYQNGLNYIALNLME--------------------KQETGNCENL- 997

Human  1292 GLISAVGVGSTGGGCGGPGPGALPPANTYASIDFLSHHLKE-ATIVK 1337
                   ||...|||...|...| ....|..:.|     || ||.|:
Zfish   998 -------VGFKTGGCCKAGINGL-HTTPYVCLGF-----KETATTVQ 1031

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IRS2NP_003740.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..31 12/29 (41%)
PH_IRS 31..147 CDD:269959 75/115 (65%)
PH 31..144 CDD:278594 74/112 (66%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 49..72 4/22 (18%)
PTB_IRS 194..297 CDD:269915 89/102 (87%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 303..411 66/111 (59%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 428..537 49/108 (45%)
YXXM motif 1 540..543 0/2 (0%)
YXXM motif 2 598..601 1/2 (50%)
YXXM motif 3 653..656 2/2 (100%)
YXXM motif 4 675..678 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 703..739 8/35 (23%)
YXXM motif 5 742..745 2/2 (100%)
YXXM motif 6 823..826 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 840..1101 77/262 (29%)
YXXM motif 7 1072..1075 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1121..1296 72/174 (41%)
irs2aXP_021322439.1 PH_IRS 24..126 CDD:269959 75/114 (66%)
PTB_IRS 157..260 CDD:269915 89/102 (87%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C194338096
Domainoid 1 1.000 609 1.000 Domainoid score I1649
eggNOG 1 0.900 - - E1_28N3R
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2778
Inparanoid 1 1.050 964 1.000 Inparanoid score I2477
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D121380at7742
OrthoFinder 1 1.000 - - FOG0001178
OrthoInspector 1 1.000 - - otm27950
orthoMCL 1 0.900 - - OOG6_105771
Panther 1 1.100 - - O PTHR10614
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4611
SonicParanoid 1 1.000 - - X1499
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 1 1.500 - -
1717.290

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