DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IRS2 and Irs2

DIOPT Version :9

Sequence 1:	NP_003740.2	Gene:	IRS2 / 8660	HGNCID:	6126	Length:	1338	Species:	Homo sapiens
Sequence 2:	NP_001074681.1	Gene:	Irs2 / 384783	MGIID:	109334	Length:	1321	Species:	Mus musculus

Alignment Length:	1345	Identity:	1149/1345 - (85%)
Similarity:	1186/1345 - (88%)	Gaps:	31/1345 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MASPPRHGPPGPASGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEATAGGG 65
            |||.|..|||..|.||||||||||||||||||||||||||||||||||||||||.|||||:|.||
Mouse     1 MASAPLPGPPASAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGTGGDEASAAGG 65

Human    66 SAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYFAVAAENEQ 130
            |.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 SPPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYFAVAAENEQ 130

Human   131 EQEGWYRALTDLVSEGRAAAGDAPPAAAPAASCSASLPGALGGSAGAAGAEDSYGLVAPATAAYR 195
            |||||||||||||||||:..|.   :.....||||||||.|||||||||.:|:||||.||||.||
Mouse   131 EQEGWYRALTDLVSEGRSGEGG---SGTTGGSCSASLPGVLGGSAGAAGCDDNYGLVTPATAVYR 192

Human   196 EVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMNIRRCGHSDSFFFIEVG 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   193 EVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMNIRRCGHSDSFFFIEVG 257

Human   261 RSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRH 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   258 RSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRH 322

Human   326 HHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCRVRTASEGDGGAAAGAAAAGARPVSVAGSPL 390
            |||||||||||||||||||||||||||||||:|||||||||||||||.||..||.||:|||||||
Mouse   323 HHLVNLPPSQTGLVRRSRTDSLAATPPAAKCTSCRVRTASEGDGGAAGGAGTAGGRPMSVAGSPL 387

Human   391 SPGPVRAPLSRSHTLSGGCGGRGSKVALLPAGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHG 455
            ||||||||||||||||.|||||.|||.|.||||||||||||||||||||||||||||||||||||
Mouse   388 SPGPVRAPLSRSHTLSAGCGGRPSKVTLAPAGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHG 452

Human   456 SGSYPPPPGPHPPLPHPLHHGPGQRPSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFCSHRSNT 520
            |||||.|||.||.|||||||..||||||||||||||||||||||||||||||||||||.||||||
Mouse   453 SGSYPLPPGSHPHLPHPLHHPQGQRPSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFSSHRSNT 517

Human   521 PESIAETPPARDGGGGGEFYGYMTMDRPLSHCGRSYRRVSGDAAQDLDRGLRKRTYSLTTPARQR 585
            |||||||||||| |.|||.||||:||||||||||.|||||||.||||||||||||||||||||||
Mouse   518 PESIAETPPARD-GSGGELYGYMSMDRPLSHCGRPYRRVSGDGAQDLDRGLRKRTYSLTTPARQR 581

Human   586 PVPQPSSASLDEYTLMRATFSGSAGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGAD 650
            .||||||||||||||||||||||:||||||.|||||||||:||||||||||||||:|||||||||
Mouse   582 QVPQPSSASLDEYTLMRATFSGSSGRLCPSFPASSPKVAYNPYPEDYGDIEIGSHKSSSSNLGAD 646

Human   651 DGYMPMTPGAALAGSGSGSCRSDDYMPMSPASVSAPKQILQPRAAAAAAAAVPSAGPAGPAPTSA 715
            ||||||||||||...|..||:|||||||||.||||||||||||    .|||:|.:|.|.|||.|.
Mouse   647 DGYMPMTPGAALRSGGPNSCKSDDYMPMSPTSVSAPKQILQPR----LAAALPPSGAAVPAPPSG 707

Human   716 AGRTFPASGGGYKASSPAESSPEDSGYMRMWCGSKLSMEHADGKLLPNGDYLNVSPSDAVTTGTP 780
            .|||||.:|||||||||||||||||||||||||||||||:.|.||||||||||:|||:|.|.|||
Mouse   708 VGRTFPVNGGGYKASSPAESSPEDSGYMRMWCGSKLSMENPDPKLLPNGDYLNMSPSEAGTAGTP 772

Human   781 PDFFSAALHPGGEPLRGVPGCCYSSLPRSYKAPYTCGGDSDQYVLMSSPVGRILEEERLEPQATP 845
            || |||||..|.|.|:|:||.||||||||||||.:|.||:|||||||||||||||||||||||||
Mouse   773 PD-FSAALRGGSEGLKGIPGHCYSSLPRSYKAPCSCSGDNDQYVLMSSPVGRILEEERLEPQATP 836

Human   846 GPSQAASAFGA---GPTQPPHPVVPSPVRPS--GGRPEGFLGQRGRAVRPTRLSLEGLPSLPSMH 905
            |    |..|||   ..|||.|..|||.:|||  |||||||||||.|||||||||||||.:||||.
Mouse   837 G----AGTFGAAGGSHTQPHHSAVPSSMRPSAIGGRPEGFLGQRCRAVRPTRLSLEGLQTLPSMQ 897

Human   906 EYPLPPEPKSPGEYINIDFGEPGARLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSDSR 970
            |||||.|||||||||||||||.|.|||||||||||||||||||||||||||||||||||||||||
Mouse   898 EYPLPTEPKSPGEYINIDFGEAGTRLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSDSR 962

Human   971 QRSPLSDYMNLDFSSPKSPKPGAPSGHPVGSLDGLLSPEASSPYPPLPPRPSASPSSSLQPPPPP 1035
            |||||||||||||||||||||...||..|||:||||||||||||||||||||.||||..|  |.|
Mouse   963 QRSPLSDYMNLDFSSPKSPKPSTRSGDTVGSMDGLLSPEASSPYPPLPPRPSTSPSSLQQ--PLP 1025

Human  1036 PAPGELYRLPPASAVATAQGPGAASSLSSDTGDNGDYTEMAFGVAATPPQPIAAPPKPEAARVAS 1100
            ||||:||||||||| ||:|||.|.||:||:.|||||||||||||||||||||.||||||.|||||
Mouse  1026 PAPGDLYRLPPASA-ATSQGPTAGSSMSSEPGDNGDYTEMAFGVAATPPQPIVAPPKPEGARVAS 1089

Human  1101 PTSGVKRLSLMEQVSGVEAFLQASQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPVSPSF 1165
            ||||:||||||:||||||||||.||||||||||||||||||||||||||||||||||||||||||
Mouse  1090 PTSGLKRLSLMDQVSGVEAFLQVSQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPVSPSF 1154

Human  1166 AHNPKRHNSASVENVSLRKSSEGGVGVGPGGGDEPPTSPRQLQP--APPLAPQGRPWTPGQPGGL 1228
            |||.|||||||||||||||||||...:  ||||||||||.|.||  |.|..||.|||.|||||.|
Mouse  1155 AHNSKRHNSASVENVSLRKSSEGSSTL--GGGDEPPTSPGQAQPLVAVPPVPQARPWNPGQPGAL 1217

Human  1229 VGCPGSGGSPMRRETSAGFQNGLNYIAIDVREEPGLPPQPQPPPPPLPQPGDKSSWGRTRSLGGL 1293
            :||||...||||||||.||||||||||||||.|.|...|.|      ||||||:||.||||||||
Mouse  1218 IGCPGGSSSPMRRETSVGFQNGLNYIAIDVRGEQGSLAQSQ------PQPGDKNSWSRTRSLGGL 1276

Human  1294 ISAVGVGSTGGGCGGPGPGALPPANTYASIDFLSHHLKEATIVKE 1338
            :..||.....|.|||||.||||.|:||||||||||||||||:|||
Mouse  1277 LGTVGGSGASGVCGGPGTGALPSASTYASIDFLSHHLKEATVVKE 1321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IRS2	NP_003740.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		23/29 (79%)
		PH_IRS	31..147	CDD:269959	111/115 (97%)
		PH	31..144	CDD:278594	108/112 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..72		18/22 (82%)
		PTB_IRS	194..297	CDD:269915	102/102 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	303..411		100/107 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..537		100/108 (93%)
		YXXM motif 1	540..543		2/2 (100%)
		YXXM motif 2	598..601		2/2 (100%)
		YXXM motif 3	653..656		2/2 (100%)
		YXXM motif 4	675..678		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	703..739		26/35 (74%)
		YXXM motif 5	742..745		2/2 (100%)
		YXXM motif 6	823..826		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	840..1101		218/265 (82%)
		YXXM motif 7	1072..1075		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1296		138/176 (78%)
Irs2	NP_001074681.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		24/30 (80%)
		PH_IRS	31..143	CDD:269959	107/111 (96%)
		PH	31..143	CDD:278594	107/111 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..73		17/21 (81%)
		PTB_IRS	191..294	CDD:269915	102/102 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	299..536		219/237 (92%)
		YXXM motif 1	536..539		2/2 (100%)
		YXXM motif 2	594..597		2/2 (100%)
		YXXM motif 3	649..652		2/2 (100%)
		YXXM motif 4	671..674		2/2 (100%)
		YXXM motif 5	734..737		2/2 (100%)
		YXXM motif 6	814..817		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..871		22/40 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	888..1091		177/205 (86%)
		YXXM motif 7	1061..1064		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1110..1198		79/89 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1251..1275		16/29 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83967231
Domainoid	1	1.000	1733	1.000	Domainoid score	I474
eggNOG	1	0.900	-	-		E1_28N3R
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2778
Inparanoid	1	1.050	2274	1.000	Inparanoid score	I1177
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39151
OrthoDB	1	1.010	-	-		D154392at33208
OrthoFinder	1	1.000	-	-		FOG0001178
OrthoInspector	1	1.000	-	-		oto115634
orthoMCL	1	0.900	-	-		OOG6_105771
Panther	1	1.100	-	-	LDO	PTHR10614
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4611
SonicParanoid	1	1.000	-	-		X1499
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	19	19.300