DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IRS2 and ist-1

DIOPT Version :9

Sequence 1:	NP_003740.2	Gene:	IRS2 / 8660	HGNCID:	6126	Length:	1338	Species:	Homo sapiens
Sequence 2:	NP_001360631.1	Gene:	ist-1 / 180978	WormBaseID:	WBGene00002163	Length:	1188	Species:	Caenorhabditis elegans

Alignment Length:	978	Identity:	203/978 - (20%)
Similarity:	301/978 - (30%)	Gaps:	324/978 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    73 LEYYESEKKWRSKAG-APKRVIALDCCLNI-NKRADAKHKYLIALYTKDEYFAVAAENE-QEQEG 134
            ||.:||||.:|  || |.|.::.|....|: ::..|||.|..:.|...||...:..|.. ...||
Worm   226 LELHESEKSYR--AGKAAKHMVDLSMSFNVHSEHYDAKLKKCLCLMGPDETICMRPEGGILTIEG 288

Human   135 WYRALTDLVSEGRAAAGDAPPAAAPAASCSASLPGALGGSAGAAGAEDSYGLVAPATAAYREVWQ 199
            |.||:..|:.|.|....|..|.                       .||.:      .||| :| :
Worm   289 WRRAIVKLIHESRRRKMDRVPR-----------------------PEDIF------DAAY-DV-R 322

Human   200 VNLKPKGLGQ----------------SKNLTGVYRLCLSARTIGFVKLNCEQPSV---------- 238
            |.|.||.|.:                :|.|.|..||||...|:..|.| |.:|:.
Worm   323 VCLFPKNLEKYVESLKTDGFTNICTVAKELLGKKRLCLYPNTLAIVDL-CIEPTAYGLPPAGFPP 386

Human   239 -------TLQLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETI-------LE 289
                   .|:...:...|..:::|::.:|:.:.....||..|.|.:.|.:.|:..:       ||
Worm   387 FRASSMFILERNTVAYYGFRENYFYVRIGKGSPYRGFELLFQVDTNEVCKEIYSRLRALADRDLE 451

Human   290 AMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAA 354
            ..|.     |...|.:|...|..:   :|||....|...::|             ||...||...
Worm   452 NRKQ-----ESIRRPESDMHGMES---LSVPSPLLHRTKLSL-------------DSPVITPRDR 495

Human   355 KC---SSCRVRTASEGDGGAAAGAAAAGARPVSVAGSPLSPGPVRAPLSRSHTLSGGCGGRGSKV 416
            :.   ..|....:.|.|..|.:...|...||....|:          ....| ||.....|||..
Worm   496 RLMLGRECLSFASLEKDDSAPSSPFANYNRPRGSLGN----------FQLDH-LSRFDQPRGSIH 549

Human   417 ALLPAGGALQHSRSMSMPVAHSPPAATSPG---SLSSSSGHGSGSYPPPPGPHPPLPHPLHHGPG 478
            :|    |.:...|.....:....|.....|   :|..|.||
Worm   550 SL----GNIPIDRPRVSTLQSVKPGKEETGLREALLESYGH------------------------ 586

Human   479 QRPSSGSASASGS---PSDPGFMSLDEYGSSPGDLRAFCSHRSNTPESI-AETPPARDGGG--GG 537
            .|..:.:.|..|.   |.....||.:.......|::........:.|.| ...||.:....  .|
Worm   587 LRKKNSTQSERGEIVVPEQERKMSDNRPRLRTQDIKTVTKPELKSEEPIRPRLPPLKFNANKPSG 651

Human   538 EFYGYMTMDRPL-------SHCGRSYRRVSGDAAQDLDRGLRKRTYSLTTPARQRP--VPQPSSA 593
            ||...:..::.|       .:.||::.      .....|.::|.......|....|  |.:....
Worm   652 EFLLSLQREKELMEEARKNGYDGRTHN------PDGTPREIKKDFLDTVCPQAAAPEVVIKEKII 710

Human   594 SLDEYTLMRATFSGSA--GRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGADDGYMPM 656
            :.|.||||     |.|  |:|        ..:....| .|.||....|.|.:        |..|.
Worm   711 NNDTYTLM-----GPADWGKL--------EDIVKDDY-SDSGDSCYSSRRGT--------GSQPT 753

Human   657 TPGAA-LAGSGSGSCRSDDYMPMSPASVSAPKQILQPRAAAAAAAAVPSAGPAGPAPTSAAGRTF 720
            .|.|: ||      |:    |.....|..|.:|..|.|        :|   |....|.|.  |..
Worm   754 RPAASHLA------CQ----MQNRTQSFGAKQQTFQNR--------LP---PTVNLPDSE--RKI 795

Human   721 PASGGGYKASSPAESSPEDSGYMRMWCGSK-----LSMEHADGKLLPNGDYLNVSPSDAVTTGTP 780
            .|:..|  .|:..:...||........|||     :.:.  |.:.|.:..:...||:...|:|.
Worm   796 SAANQG--TSNQLDLPQEDPRKRAFSLGSKNFFNLIGLN--DFRRLVSKRHRTSSPNHTSTSGI- 855

Human   781 PDFFSAALHPGGEPLRGVPGCCYSSLPRSYKAPYTCGGDSDQYVLMSSPVGRILEEERLEPQATP 845
                                    ||..|..:|             |:....:...|.||...|
Worm   856 ------------------------SLNSSNASP-------------SASSNFLASSEYLEHART- 882

Human   846 GPSQAASAFGAGPTQPPHPVVPSPVRPSGGRPEGFLGQRGRAVRPTRLSLEGLPSLPSMHEYPLP 910
                  .:||:..:.|                        :::...|.|               .
Worm   883 ------DSFGSARSSP------------------------KSLHTQRTS---------------S 902

Human   911 PEPKSPGEYINIDFGEPGARLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSD-SRQRSP 974
            |:.:|..:.|:|||...|           .::||.:...       ..|.|.||.|.| .|::..
Worm   903 PKRRSDEDLISIDFSRLG-----------KNSASDTKRF-------PFGGGGPGGSFDYDREKRE 949

Human   975 LSD 977
            ..|
Worm   950 KED 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IRS2	NP_003740.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		PH_IRS	31..147	CDD:269959	28/76 (37%)
		PH	31..144	CDD:278594	27/73 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..72
		PTB_IRS	194..297	CDD:269915	32/142 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	303..411		23/110 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..537		18/117 (15%)
		YXXM motif 1	540..543		0/2 (0%)
		YXXM motif 2	598..601		2/2 (100%)
		YXXM motif 3	653..656		0/2 (0%)
		YXXM motif 4	675..678		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	703..739		8/35 (23%)
		YXXM motif 5	742..745		0/2 (0%)
		YXXM motif 6	823..826		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	840..1101		24/139 (17%)
		YXXM motif 7	1072..1075
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1296
ist-1	NP_001360631.1	PH-like	213..301	CDD:388408	28/76 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N3R
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001178
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900