Protein Alignment IRS2 and irs2

DIOPT Version :10

• Sequence 1: NP_003740.2
• Gene: IRS2 / 8660
• HGNCID: 6126
• Length: 1338
• Species: Homo sapiens
• Sequence 2: XP_002933054.3
• Gene: irs2 / 100498409
• XenbaseID: XB-GENE-6455904
• Length: 1007
• Species: Xenopus tropicalis
• Alignment Length: 1364
• Identity: 636/1364 - (46%)
• Similarity: 756/1364 - (55%)
• Gaps: 383/1364 - (28%)

Human     1 MASPPRHGPPGPASGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEATAGGG 65
            ||||  |.|..|......|||:|||||:.||:|||||||||||||||||||..|.|...|
 Frog     1 MASP--HSPVQPLLPVSLNLNHNNNNNSSSVKKCGYLRKQKHGHKRFFVLREAGEGCPAA----- 58

Human    66 SAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYFAVAAENEQ 130
                  ||||||||||||||:.|.||||:||.|||||||||||:||||||||:||||||||::||
 Frog    59 ------RLEYYESEKKWRSKSAAAKRVISLDSCLNINKRADAKNKYLIALYTRDEYFAVAADSEQ 117

Human   131 EQEGWYRALTDLVSEGR----AAAGDAPPAAAP-AASCSASLPGALGGSAGAAGAEDSYGLVAPA 190
            |||.||||||:|:|.||    |.||.......| .||||:|....|      |..|| |||:.||
 Frog   118 EQESWYRALTELLSTGRGAKEACAGTGGCCCCPGTASCSSSCTNHL------ALTED-YGLITPA 175

Human   191 TAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMNIRRCGHSDSFF 255
            .|.|:|:|||||||:||||.||:|||||||||||:|.||:||.|.|||||||||||||||||::|
 Frog   176 NAVYKEMWQVNLKPRGLGQIKNMTGVYRLCLSARSISFVRLNSETPSVTLQLMNIRRCGHSDNYF 240

Human   256 FIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVP 320
            |:||||||.|||||:|||.||:||||:|||||||||||::||.|||||||||||.|   :|||||
 Frog   241 FVEVGRSASTGPGEIWMQVDDTVVAQSIHETILEAMKAMRELVEFRPRSKSQSSSS---NPISVP 302

Human   321 GARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCRVRTASEGDGGAAAGAAAAGARPVSV 385
            |  |.|||..||||||||.||:|||..:.:...:..:|.|:|||||||..:..          :|
 Frog   303 G--RRHHLNQLPPSQTGLTRRTRTDFPSTSVCVSANTSSRLRTASEGDNLSNR----------TV 355

Human   386 AGSPLSPGPVRAPLSRSHTLSGGCGGRGSKVALLPAGGALQHSRSMSMPVAHSPPAATSPGSLS- 449
            .||||||..:|||||||||||  ..||.:|  |:|..|.|||||||||||..|||.|.||.|||
 Frog   356 TGSPLSPSMLRAPLSRSHTLS--LCGRNTK--LVPIPGPLQHSRSMSMPVPRSPPTAASPISLSS 416

Human   450 -SSSGHGSGSYP--PPPGPHPPLPHPLHHGPGQRPSSGSASASGSPSDPGFMSLDEYGSSPGDL- 510
             |||||||.|.|  ||                 :..|.||||||||||.||||||||.||||::
 Frog   417 GSSSGHGSTSDPLIPP-----------------QSFSCSASASGSPSDTGFMSLDEYSSSPGEIA 464

Human   511 RAFCSHRSNTPESIAETPPARDGGGGGEFYGYMTMDRPL-SHCGRSYRRVSGDAAQDLDRGLRKR 574
            |.:.|..|.||:|.:.|||..     ||..|||:|:|.. ..|  |.|.:.|..|   ::..|||
 Frog   465 RVYLSCPSGTPDSASATPPHH-----GELNGYMSMERQFPGVC--SCRHLEGSVA---EKCARKR 519

Human   575 TYSLTTPARQRPV-PQPSSASLDEYTLMRATFSGSAGRLCPSCPASSPKVAYHPYPEDYGDIEIG 638
            |||||||.|||.. |..|||||||.||:|||:.||:|.|     :|||||:|.||||||.|:|||
 Frog   520 TYSLTTPGRQRMAPPHVSSASLDEATLVRATYKGSSGLL-----SSSPKVSYQPYPEDYADVEIG 579

Human   639 SHRSSSSNLGADDGYMPMTPGAALAGSGSGSCRSDDYMPMSPASVSAPKQILQPRAAAAAAAAVP 703
            ..         |||||||:.|..::        |.||:||||||||||:||||||
 Frog   580 RQ---------DDGYMPMSHGVGVS--------SSDYVPMSPASVSAPQQILQPR---------- 617

Human   704 SAGPAGPAPTSAAGRTFPASGGGYKASSPAESSPEDS--GYMRMWCGSKLSMEHADGKLLPNGDY 766
                      :....||             |.|.|||  ||||||||.|       .:.:|  .:
 Frog   618 ----------TCCSETF-------------EGSQEDSPDGYMRMWCGPK-------SRTVP--VH 650

Human   767 LNVSPSDAVTTGTPPDFFSAALHPGGEPLRGVPGCCYSSLPRSYKAPYTCGGDSDQYVLMSSPVG 831
            ..:||::::|:.||||:|.         ::....||.::   |.........:.:.||:|.||
 Frog   651 QRLSPAESLTSFTPPDYFY---------MQSKNSCCETN---SVACRSISPAEVEPYVMMRSP-- 701

Human   832 RILEEERLEPQATPGPSQAASAFGAGPTQPPHPVVPSPVRPSGGRPEGFLGQRGRAVRPTRLSLE 896
                              |:|:                             |..|..||:||:
 Frog   702 ------------------ASSS-----------------------------QHIRIARPSRLA-- 717

Human   897 GLPSLPSMHEYPLPPEPKSP--GEYINIDFGE--PGARLSPPAPPLLASAASSSSLLSA-SSPAS 956
             ||:||||.|:  |||..||  ||||:|.|||  |...||.|.|    :.|:.|.|||| .||||
 Frog   718 -LPTLPSMSEH--PPESSSPPGGEYIHIYFGETRPQESLSVPPP----TTATESVLLSAGGSPAS 775

Human   957 SLGSGTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPGAPSGHPVGSLDGLLSPEASSPYPPLPPRP 1021
            |..||:      ..||||:|||||||| .|.|||
 Frog   776 SSSSGS------GPQRSPVSDYMNLDF-CPPSPK------------------------------- 802

Human  1022 SASPSSSLQPPPPPPAPGELYRLPPASAVATAQGPGAASSLSSDTGDNGDYTEMAFGVAATPPQP 1086
                                                  |.::|..|.|.|||||:       |:.
 Frog   803 --------------------------------------SKINSSLGPNSDYTEMS-------PRK 822

Human  1087 IAAPPKP-----EAARVASPTSGVKRLS-LMEQVSGVEAFLQASQPPDPHRGAKVIRADPQGGRR 1145
            |:|....     |.:.:....|||:.|: ||:::.|  .|...|.||||:||||:||||||||||
 Frog   823 ISACSMSDVSLHETSSLEGAGSGVQCLTLLMDKIPG--NFSLPSPPPDPNRGAKLIRADPQGGRR 885

Human  1146 RHSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGVGVGPGGGDEPPTSPRQLQPA 1210
            |||||||||||.||||||||||:||||:||||||||.|                   |...|:
 Frog   886 RHSSETFSSTTQVTPVSPSFAHSPKRHSSASVENVSTR-------------------SGETLE-- 929

Human  1211 PPLAPQGRPWTPGQPGGLVGCPGSGGSPMRRETSAGFQNGLNYIAIDVREEPGLPPQPQPPPPPL 1275
               ||:              |    ||||.|||||||||||||||:::          .|....|
 Frog   930 ---APE--------------C----GSPMCRETSAGFQNGLNYIAMEL----------SPEKRNL 963

Human  1276 PQPGDKSSWGRTRSLGGLISAVGVGSTGGGCGGPGPGALPPANTYASIDFLSHH-LKEATIVKE 1338
            ......||.|...:||  ::::.:||                  |:|||||.|: ||.||.|:|
 Frog   964 LLLTQASSRGHLPALG--LASLDIGS------------------YSSIDFLGHNRLKGATTVRE 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IRS2	NP_003740.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		15/29 (52%)
		PH_IRS	31..147	CDD:269959	84/115 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	49..72		6/22 (27%)
		PTB_IRS	194..297	CDD:269915	82/102 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	303..411		58/107 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	428..537		60/113 (53%)
		YXXM motif 1	540..543		1/2 (50%)
		YXXM motif 2	598..601		1/2 (50%)
		YXXM motif 3	653..656		2/2 (100%)
		YXXM motif 4	675..678		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	703..739		4/35 (11%)
		YXXM motif 5	742..745		2/2 (100%)
		YXXM motif 6	823..826		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	840..1101		75/270 (28%)
		YXXM motif 7	1072..1075		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1121..1296		84/174 (48%)
irs2	XP_002933054.3	PH_IRS	29..134	CDD:269959	84/115 (73%)
		PTB_IRS	179..282	CDD:269915	82/102 (80%)