DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERPINA6 and Spn42Dd

DIOPT Version :9

Sequence 1:	NP_001747.3	Gene:	SERPINA6 / 866	HGNCID:	1540	Length:	405	Species:	Homo sapiens
Sequence 2:	NP_001163067.1	Gene:	Spn42Dd / 49808	FlyBaseID:	FBgn0028988	Length:	372	Species:	Drosophila melanogaster

Alignment Length:	409	Identity:	109/409 - (26%)
Similarity:	193/409 - (47%)	Gaps:	45/409 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     4 LLYTCL-LWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISP 67
            :.|.|: ||:.     :|........|..:|..|                      ..:|:.:||
  Fly     1 MYYLCIFLWVT-----SVACQTSKEIYQLLSKSH----------------------TNQNLVVSP 38

Human    68 VSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALF 132
            |||...|:|:.:|..|.|..:|...||....::.......| ..|:.|..:.:..: :.:.|.::
  Fly    39 VSIETILSMVFMGAEGSTAKELQSALGLPSEDKEAVAARYG-ALLNDLQGQEEGPI-LKLANRIY 101

Human   133 LDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLF--SGLDSPAIL 195
            ::....|.::::..::..::||..:::..:...|:.:||.:|.::|.|||..:.  ..:.|....
  Fly   102 VNDQYSLNQNYNLAVREPFKSEAESISLTNGPVAAERINQWVLDQTSGKIKGMIDPGSMTSDVKA 166

Human   196 VLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYVGN 260
            :|||.|:|||.|...||.|.||...|.|.....|.|.||.|..|....:..:|..|::::.|:.:
  Fly   167 LLVNAIYFKGQWESKFDPAKTRASTFQVTANKSVPVQMMAQMGTFRANYFRDLDAQVIELPYLNS 231

Human   261 G---TVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIA 322
            .   |:|.....:|     ::||....:. ::..|.:.:|.|.:||..|....:|.:.||::||.
  Fly   232 NLSMTIFLPREVEG-----LSALEEKIVG-FARPLVAKEVYLKLPKFKIEFRDELKETLEKLGIR 290

Human   323 DLFTNQANFSRITQD-AQLKSSKVVHKAVLQLNEEGVDTAGSTGVTL-NLTSKPIILRFNQPFII 385
            :|||::::.|.:..| :..|.|:|.|||.|::||||.:.||:|.|.: |.......|..:.||..
  Fly   291 ELFTDKSDLSGLFADKSGGKVSQVSHKAFLEVNEEGAEAAGATSVAVTNRAGFSTFLMADHPFAF 355

Human   386 MIFDHFTWSSLFLARVMNP 404
            :|.|..|  ..|..||::|
  Fly   356 VIRDANT--IYFQGRVVSP 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERPINA6	NP_001747.3	alpha-1-antitrypsin_like	42..401	CDD:239011	98/365 (27%)
Spn42Dd	NP_001163067.1	SERPIN	16..369	CDD:238101	101/384 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020