Protein Alignment ALDH4A1 and PUT2

DIOPT Version :10

• Sequence 1: NP_003739.2
• Gene: ALDH4A1 / 8659
• HGNCID: 406
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_011902.1
• Gene: PUT2 / 856432
• SGDID: S000001079
• Length: 575
• Species: Saccharomyces cerevisiae
• Alignment Length: 575
• Identity: 241/575 - (41%)
• Similarity: 342/575 - (59%)
• Gaps: 22/575 - (3%)

Human     2 LLPAPALRRALLSRPWTGAGLRWKHTSSLK-VANEPVLAFTQ-GSPERDALQKALKDLKGRMEAI 64
            :|.|..|:.....|.::..|    |....| :.||||..|.. ...:.|.|:.:|...|.....:
Yeast     1 MLSARCLKSIYFKRSFSQLG----HIKPPKHIRNEPVKPFRNIDLKDWDLLRASLMKFKSSSLEV 61

Human    65 PCVVGDEEVWTSDVQY---QVSPFNHGHKVAKFCYA-DKSLLNKAIEAALAARKEWDLKPIADRA 125
            |.|:..|.::.::.:.   |.:|.||...:|....| :|.::| |::||..|:|:|...|..||:
Yeast    62 PLVINGERIYDNNERALFPQTNPANHQQVLANVTQATEKDVMN-AVKAAKDAKKDWYNLPFYDRS 125

Human   126 QIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPP 190
            .|||||||::|...|.::||.||:||||.|.|||||...||.||||:..|||.:|..|||:....
Yeast   126 AIFLKAADLISTKYRYDMLAATMLGQGKNVYQAEIDCITELSDFFRYYVKYASDLYAQQPVESAD 190

Human   191 ST-NSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGL 254
            .| |...||.|||||.|:||||||||..||.||||||||.|:||||.||.|::|.:..:|.||||
Yeast   191 GTWNKAEYRPLEGFVYAVSPFNFTAIAANLIGAPALMGNTVVWKPSQTAALSNYLLMTVLEEAGL 255

Human   255 PPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNL--DRFHTFPRLAGECGG 317
            |..:|.|:|.|.....|.|.:.:....::||||...||.|:.::...:  .::..:||:.||.||
Yeast   256 PKGVINFIPGDPVQVTDQVLADKDFGALHFTGSTNVFKSLYGKIQSGVVEGKYRDYPRIIGETGG 320

Human   318 KNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKG---RLLEEHSRIKVGD 379
            ||||.||.||::...|..|:|..||:.||||||.||||:|.|...:...   .:|:..:.:.:..
Yeast   321 KNFHLVHPSANISHAVLSTIRGTFEFQGQKCSAASRLYLPESKSEEFLSDMFGILQSQNVVPMNT 385

Human   380 PAE-----DFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDP 439
            .|.     :...|...||..:||.::.|.:|.|:..|.|.||.||:.|.|.|:||.|.::::|.|
Yeast   386 SASPISGGNLRGFMGPVIHEQSFDKLVKVIEDAKKDPELEILYGGQYDKSQGWFVGPTVIKAKRP 450

Human   440 QEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNF 504
            ..|.|..|.|||:|:||.|||.::.|...::|:|:.|.||||:|::|:..::.|.:.|:.:||||
Yeast   451 DHPYMSTEFFGPILTVYEYPDTEFNEICDIIDNTSQYALTGAIFAKDRKAIEYADEKLKFSAGNF 515

Human   505 YINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWSY 559
            |||||.||::|.||.|||||.|||:||.|||:.:.|:.|.:..||....|.|:.|
Yeast   516 YINDKCTGAVVSQQWFGGARMSGTDDKAGGPNILSRFVSIRNTKENFYELTDFKY 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALDH4A1	NP_003739.2	ALDH_F4-17_P5CDH	32..553	CDD:143441	231/536 (43%)
PUT2	NP_011902.1	D1pyr5carbox1	29..574	CDD:273517	234/543 (43%)