Protein Alignment ALDH4A1 and P5CDh1

DIOPT Version :10

• Sequence 1: NP_003739.2
• Gene: ALDH4A1 / 8659
• HGNCID: 406
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_649368.2
• Gene: P5CDh1 / 40434
• FlyBaseID: FBgn0037138
• Length: 574
• Species: Drosophila melanogaster
• Alignment Length: 533
• Identity: 328/533 - (61%)
• Similarity: 409/533 - (76%)
• Gaps: 3/533 - (0%)

Human    32 VANEPVLAFTQGSPERDALQKALKDLKGRMEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCY 96
            :||||:|.:.:.|.||.||::|||......|.||.|:|.:|..|.:|:|||.|.:|.||:|.|.|
  Fly    41 IANEPILGYLKDSKERKALEQALKGTASSCEDIPIVIGGKEYKTPEVRYQVMPHDHQHKLASFYY 105

Human    97 ADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEID 161
            |||.|:.|||:.|:..:.:||...||||.:|:.||||:::...|.::.|.||:||.||.||||||
  Fly   106 ADKKLIEKAIKTAVETQPKWDRVSIADRLKIWEKAADLMATTYRQDLNAATMLGQSKTAIQAEID 170

Human   162 AAAELIDFFRFNAKYAVELEGQQPIS--VPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPA 224
            :|||||||.|.||.:..|:...||||  :..:.||..|||::||:||:||||||||||||:..||
  Fly   171 SAAELIDFIRMNAYFLKEVTKYQPISENIKVTKNSLRYRGIDGFIAAVSPFNFTAIGGNLSYTPA 235

Human   225 LMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVP 289
            ||||.|||||||||||:::.:::|:||||:|..::.|||||||:||||:|:|.||.|||||||||
  Fly   236 LMGNGVLWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTITASPHLAGINFTGSVP 300

Human   290 TFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRL 354
            ||..|||||..|:|.:..||||.||||||||||:|.||||||||:.|:||||||.|||||||||:
  Fly   301 TFNRLWKQVGNNIDNYVNFPRLTGECGGKNFHFIHASADVESVVTSTIRSAFEYCGQKCSACSRM 365

Human   355 YVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGG 419
            |||.|||||||..|:.|.:::|:|| .:||.:|.|||||.|:|.||..::|||:.||:|.|||||
  Fly   366 YVPESLWPQIKEGLVCEAAKLKIGD-VQDFSSFTSAVIDDKAFKRITGYIEHAKKSPNLEILAGG 429

Human   420 KCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFS 484
            ...||.||||.|.||.||||::.||.|||||||||:|||.:....||::||.::|.:.||||||.
  Fly   430 TYSDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVYKESDLLETMKLVHTSTKFALTGAVFG 494

Human   485 QDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKE 549
            ||:|.|:.|.:..:.||||||||||||||:||||||||.|.||||||.|||||||||||||.|||
  Fly   495 QDEDFVKCALQEFKMAAGNFYINDKSTGSVVGQQPFGGGRMSGTNDKAGGPHYILRWTSPQSIKE 559

Human   550 THKPLGDWSYAYM 562
            |..||.|.:|.||
  Fly   560 TFVPLRDVNYPYM 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALDH4A1	NP_003739.2	ALDH_F4-17_P5CDH	32..553	CDD:143441	322/522 (62%)
P5CDh1	NP_649368.2	ALDH_F4-17_P5CDH	41..563	CDD:143441	322/522 (62%)