Protein Alignment ALDH4A1 and put2

DIOPT Version :10

• Sequence 1: NP_003739.2
• Gene: ALDH4A1 / 8659
• HGNCID: 406
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_001342759.1
• Gene: put2 / 2540387
• PomBaseID: SPBC24C6.04
• Length: 548
• Species: Schizosaccharomyces pombe
• Alignment Length: 534
• Identity: 265/534 - (49%)
• Similarity: 346/534 - (64%)
• Gaps: 11/534 - (2%)

Human    32 VANEPVLAFTQGSPERDALQKALKDLKGRME-AIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFC 95
            :.|||...:...|.:|:.:.||.|:|:..:. .||.::..:||.|:.:..|..||.|...||::.
pombe    12 IKNEPPKHYGPNSADREGIVKAYKELEAELPVTIPVIIDGKEVETNTIGEQRCPFEHKKVVARYH 76

Human    96 YADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEI 160
            .|....:..||||||..:|.|:..|.|||:.||||||.::|...|.:::|.||:||||.:.||||
pombe    77 RAGAKHVEDAIEAALRGKKVWESLPFADRSAIFLKAAHLISTKYRYKLMAATMIGQGKNIWQAEI 141

Human   161 DAAAELIDFFRFNAKYAVELEGQQPISVPPST-NSTVYRGLEGFVAAISPFNFTAIGGNLAGAPA 224
            ||..|:|||.|||.|||.||...||....|.. |...||.|||||.||:|||||||.||||.||.
pombe   142 DAGMEIIDFLRFNTKYASELYASQPPENTPGVWNRMEYRPLEGFVYAITPFNFTAIAGNLAAAPL 206

Human   225 LMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVP 289
            |||||||.||||.|:|:||.||:|.||||||...:||:|.|.........:.....|::||||..
pombe   207 LMGNVVLMKPSDHAVLSSYIVYQIFREAGLPAGALQFIPGDAVEVSKVCFNHPEFAGLHFTGSTA 271

Human   290 TFKHLWKQVAQNL--DRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACS 352
            .|:.||..:.:|:  .::.|:|::.||.||||||.||.||:::|.|...:|:||||.||||||.|
pombe   272 VFRSLWGTIGENVANGKYRTYPKIVGETGGKNFHLVHSSAEIKSAVVNAVRAAFEYQGQKCSALS 336

Human   353 RLYVPHSLWPQ-IKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTIL 416
            ||||....|.. .:..|.::...:|||.|..||..|...||...||.::||.||.|.|...:.:|
pombe   337 RLYVSKYAWENGFRDELTKQVKSLKVGAPLTDFANFVGPVIHQASFNKLKKVLESAASDSEIEVL 401

Human   417 AGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGA 481
            ||||.|||.|:||||.::.||:|:..|...|:||||||||||.||.......|:|:||.|||||:
pombe   402 AGGKADDSEGFFVEPTVLLSKNPKHDIFVNELFGPVLSVYVYEDDNLDAVCDLIDTTTPYGLTGS 466

Human   482 VFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQV 546
            :|:||:.||::.|..|||||||||||||.||::||:||||||||||||||.|....:.|:.||:.
pombe   467 IFAQDRVVVRKLTDRLRNAAGNFYINDKCTGAVVGEQPFGGARASGTNDKAGSGMILSRFVSPRS 531

Human   547 IKETHKPLGDWSYA 560
            ||:|      ::||
pombe   532 IKDT------FAYA 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALDH4A1	NP_003739.2	ALDH_F4-17_P5CDH	32..553	CDD:143441	263/525 (50%)
put2	NP_001342759.1	ALDH_F4-17_P5CDH	12..537	CDD:143441	263/530 (50%)