Protein Alignment ALDH4A1 and alh-6

DIOPT Version :10

• Sequence 1: NP_003739.2
• Gene: ALDH4A1 / 8659
• HGNCID: 406
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_493946.1
• Gene: alh-6 / 173510
• WormBaseID: WBGene00000112
• Length: 563
• Species: Caenorhabditis elegans
• Alignment Length: 564
• Identity: 308/564 - (54%)
• Similarity: 404/564 - (71%)
• Gaps: 12/564 - (2%)

Human     7 ALRRALLSRPW---TGAGLRWKHTSS---LKVANEPVLAFTQGSPERDALQKALKDLKGRMEAIP 65
            |.||:|:::..   |.:||    ||:   .|..|||:|.:.:||.||..|:.||......:..:|
 Worm     5 AARRSLITQKCAASTYSGL----TSADFLKKKTNEPILEYRKGSKERQDLEAALAFYSKNITEVP 65

Human    66 CVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLK 130
            ..:||:::.....|.||.|.:|...:||:.||....:.:||:.||.||..|:.||:.:||:|.|:
 Worm    66 LRIGDKKITNKLEQKQVIPSDHRSTLAKYTYATGEQIQEAIDVALQARGAWERKPLKERAEILLR 130

Human   131 AADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNST 195
            |||:.:|..|.::.|.||:||||.:||||||||.||||||||||.:|:|||..:|||...:.|:.
 Worm   131 AADLAAGKYRMKLNASTMLGQGKNIIQAEIDAACELIDFFRFNAVFAMELEHYEPISTKITKNTM 195

Human   196 VYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQ 260
            .:||:|||||||:|||||||||||..||||||||.|||||:||:|::|.:|.:|.|||:||.|:.
 Worm   196 QFRGMEGFVAAIAPFNFTAIGGNLPTAPALMGNVSLWKPSNTAVLSNYIIYELLEEAGMPPGILS 260

Human   261 FVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHR 325
            |:|:|||:|||.:|:|.||..:||||||||||.:|::||:|||.:.|||:|.||||||||||||.
 Worm   261 FLPSDGPVFGDVITASPHLSAVNFTGSVPTFKTIWRKVAENLDNYVTFPKLIGECGGKNFHFVHP 325

Human   326 SADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSA 390
            ||.|::|.:||.|||:||.|||||||||:|.|.|:||:|..::...|..||:|| ..|...|.||
 Worm   326 SAHVDAVAAGTARSAWEYSGQKCSACSRMYAPKSIWPKILEKISAIHKEIKLGD-VRDGSVFLSA 389

Human   391 VIDAKSFARIKKWLEHARS-SPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLS 454
            |||.|:|||:|.:::.|:: :....::.||||||..|||:||.::...||:..::.||:||||::
 Worm   390 VIDDKAFARLKAYIDFAKTGADGANVVLGGKCDDKTGYFIEPTLITVTDPKSKLLTEEMFGPVVT 454

Human   455 VYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQP 519
            |.||.|.|..|.|..|...|.||||||||||||:.:..|..|||:|.||.|:|||||||||||||
 Worm   455 VLVYEDSKVDEVLATVKDATPYGLTGAVFSQDKEFLYRARDVLRDAVGNMYLNDKSTGSIVGQQP 519

Human   520 FGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWSYAYMQ 563
            |||:|.||||||.|||||.||||||..||||...|.||.|..|:
 Worm   520 FGGSRLSGTNDKAGGPHYGLRWTSPLTIKETSVSLTDWKYPSME 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALDH4A1	NP_003739.2	ALDH_F4-17_P5CDH	32..553	CDD:143441	293/521 (56%)
alh-6	NP_493946.1	ALDH_F4-17_P5CDH	34..552	CDD:143441	293/518 (57%)