Protein Alignment ALDH4A1 and aldh4a1

DIOPT Version :10

• Sequence 1: NP_003739.2
• Gene: ALDH4A1 / 8659
• HGNCID: 406
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_001096184.1
• Gene: aldh4a1 / 100124732
• XenbaseID: XB-GENE-959460
• Length: 556
• Species: Xenopus tropicalis
• Alignment Length: 554
• Identity: 430/554 - (77%)
• Similarity: 491/554 - (88%)
• Gaps: 2/554 - (0%)

Human    10 RALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGRMEAIPCVVGDEEVW 74
            |.:|:|  :.|..||.|.::.:|.|||:|.|..||.||.|||:||.:||...|.||||||.||||
 Frog     5 RGVLTR--SCARWRWHHCAAAEVKNEPILEFRSGSAERAALQQALHELKATTEEIPCVVGGEEVW 67

Human    75 TSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPR 139
            |.||:||||||.|.|:|||:|||||.||||||.||:..||||||||:.||||||.||||:|||||
 Frog    68 TKDVRYQVSPFKHSHRVAKYCYADKELLNKAINAAMGVRKEWDLKPVQDRAQIFFKAADLLSGPR 132

Human   140 RAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFV 204
            |||||||||:|||||.||||||||||||||||||||||:||..:||||:|.||||.||||||||:
 Frog   133 RAEILAKTMIGQGKTAIQAEIDAAAELIDFFRFNAKYALELTHEQPISIPVSTNSMVYRGLEGFI 197

Human   205 AAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLF 269
            ||:|||||||||||||||||||||||||||||||:|:|||||::|.|||||||:|||||||||:|
 Frog   198 AAVSPFNFTAIGGNLAGAPALMGNVVLWKPSDTAILSSYAVYKVLLEAGLPPNVIQFVPADGPVF 262

Human   270 GDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVS 334
            |||:||||||||||||||||||||||||||||||.:.||||||||||||||||||.||||||.|:
 Frog   263 GDTITSSEHLCGINFTGSVPTFKHLWKQVAQNLDVYRTFPRLAGECGGKNFHFVHASADVESTVN 327

Human   335 GTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFAR 399
            ||:||||||||||||||||||||.||||:||.||||||::|||||||:||.:|||||||.|||.|
 Frog   328 GTIRSAFEYGGQKCSACSRLYVPDSLWPRIKARLLEEHAKIKVGDPADDFSSFFSAVIDQKSFRR 392

Human   400 IKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYK 464
            |:.|:.||:|||.|.||||||||||.||:|:|.|:|||:|:|.||.||||||||:|||||:..|:
 Frog   393 IQGWISHAQSSPDLAILAGGKCDDSEGYYVQPTIIESKNPKEKIMAEEIFGPVLAVYVYPESNYR 457

Human   465 ETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTN 529
            |.|||:|||:.||||||||:|||:|::|||::||:|||||||||||||::|.||||||:||||||
 Frog   458 EVLQLIDSTSPYGLTGAVFAQDKNVLREATQILRHAAGNFYINDKSTGAVVAQQPFGGSRASGTN 522

Human   530 DKPGGPHYILRWTSPQVIKETHKPLGDWSYAYMQ 563
            ||||.||||||||||||:||||.||.:|.|.|||
 Frog   523 DKPGWPHYILRWTSPQVVKETHVPLTEWKYPYMQ 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALDH4A1	NP_003739.2	ALDH_F4-17_P5CDH	32..553	CDD:143441	416/520 (80%)
aldh4a1	NP_001096184.1	ALDH_F4-17_P5CDH	25..546	CDD:143441	416/520 (80%)