DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TNKS and Ank

DIOPT Version :9

Sequence 1:NP_003738.2 Gene:TNKS / 8658 HGNCID:11941 Length:1327 Species:Homo sapiens
Sequence 2:NP_001162819.1 Gene:Ank / 43770 FlyBaseID:FBgn0011747 Length:1549 Species:Drosophila melanogaster


Alignment Length:1285 Identity:320/1285 - (24%)
Similarity:517/1285 - (40%) Gaps:265/1285 - (20%)


- Green bases have known domain annotations that are detailed below.


Human   160 SSTAPLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDA---ANVNAKDMAGRKSSPLH 221
            |.|..:...|.....|:...:.|....|.|.|:||:.:|...:|.   :::|:.:..|..:  ||
  Fly    16 SETCAINGMALDNKNGIIKQNDATISFLRAARSGDIKKVMDFLDCGEISDINSCNANGLNA--LH 78

Human   222 FAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPL 286
            .||..|..|:...||:.|..:......|...||.|...|..:|::.|:...|:.|.:....:|||
  Fly    79 LAAKDGYVDICCELLRRGIKIDNATKKGNTALHIASLAGQHDVINQLILYNANVNVQSLNGFTPL 143

Human   287 HEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLA-----DPSAKAVLTGEYKKDELLEA---A 343
            :.||.:...:.|..||.:||:|::...||.:.|.:|     |.....:|..:.:....|.|   |
  Fly   144 YMAAQENHDNCCRTLLANGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIA 208

Human   344 RSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHN 408
            ...|:.....||...:.|.........||||:||.|..|.|..|||.:.|||:...|..:.|||.
  Fly   209 AKKNDVNAAKLLLQHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHV 273

Human   409 ACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVD 473
            ||.:|...:..|||..||.::|......||||.|:....|||...||...|.......:|.||:.
  Fly   274 ACKWGKLSLCTLLLCRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALH 338

Human   474 MAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRK 538
            ||...|      ::...|.||......|...|....||.:           |.||.    |.|  
  Fly   339 MAAQGE------HDEAAHLLLDNKAPVDEVTVDYLTALHV-----------AAHCG----HVK-- 380

Human   539 QVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGH 603
             |.:|||...||.|.:..:..||||:|.::....::|:|.||||.:.|....|.|.||.|:..|.
  Fly   381 -VAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLTPLHVASFMGC 444

Human   604 LQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQILSESTPIRTSDVDYRLLE-------A 657
            :.....||.:.:...:.:::|.|    ||:.....:.:||     :|::.||....|       |
  Fly   445 INIVIYLLQHEASADLPTIRGETPLHLAARANQADIIRIL-----LRSAKVDAIAREGQTPLHVA 504

Human   658 SKAGDLETVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPL 721
            |:.|::..:..|.. ...:|.:. ..::|. ||.||...:.::|:.||.:||:.:|..|.|..||
  Fly   505 SRLGNINIIMLLLQHGAEINAQS-NDKYSA-LHIAAKEGQENIVQVLLENGAENNAVTKKGFTPL 567

Human   722 HNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEA----------------------------- 757
            |.||.||...|.::|:::|||::.......||||.|                             
  Fly   568 HLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCA 632

Human   758 ---AAKGKY-EICKLLLKHGADPTKKNRDGNTPLDLVKE-GDTDIQDLLRGDAALLDAAKKGCLA 817
               |.|..| ||...||:||||....::.|.:||.|..: |:.|:..||.....:..|||.|.  
  Fly   633 IHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYGVISAAAKNGL-- 695

Human   818 RVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGH 882
                                 ||||:||...::.|::.||||||:::.:.:.|..|||.||.|||
  Fly   696 ---------------------TPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGH 739

Human   883 VDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLAT--- 944
            :|:....|:.:..:..:....:||||:|||:|...:..|||.|.|:|....::|.|.|.:|:   
  Fly   740 LDLVKFFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASNLG 804

Human   945 -----------------ADDIRAL--LIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAAS 990
                             ..:|.|:  .:..|.||           ::..:|:|.:...||.....
  Fly   805 YVTVMESLKIVTSTSVINSNIGAIEEKLKVMTPE-----------LMQETLLSDSDDESCDDLLD 858

Human   991 -------SIDNLTGPLAELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFE 1048
                   :.|:|....                |.::|..:....|.:    |..:.:.:.::|..
  Fly   859 HNHYKYMATDDLKANY----------------GQDQKNFDTTNTDHD----LTDVSVLNKKEILP 903

Human  1049 TEQITLDVLADMGHEELKEI-------------------GINAYGHRHKLIKGVE---------- 1084
            .|...:: |.::||:....:                   |.:..|:||..::.:.          
  Fly   904 NEMSCIE-LTEIGHKPDNVVIARSQVHLGFLVSFLVDARGGSMRGYRHNGVRIIVPPKACAEPTR 967

Human  1085 ---RLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQS---VEEEMQSTIREHR--------DG 1135
               |.:..|:..||..........:.:|:::|.|..:.|   :|.....|:|::.        |.
  Fly   968 ITCRYVKPQRVVNPPPLMEGEALVSRILEMSPVDGMFLSPITLEVPHYGTLRKNEREIIILRSDN 1032

Human  1136 GNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDER 1200
            |.:....|.|..| |.:.:|:             :||.|:....|::....|...|::.:...|.
  Fly  1033 GESWREHNLYKDI-IGEDINQ-------------TEEFHSDRIVRIVTQNVPHFFAVVSRVRQEV 1083

Human  1201 HAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFST 1265
            |                       |.|..|||...|...:...|.....|..::.:|   ||..:
  Fly  1084 H-----------------------VIGPDGGTVFSTAVPQVKAIFPPHALTKKIRVG---LQAQS 1122

Human  1266 MKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEA 1315
            :.:...    ..::|:    |:|.:..|.....:......||..|..|:|
  Fly  1123 VDLVEC----SKLLGQ----GVAVSPVVTVEPRRRKFHKAITLSIPAPKA 1164

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TNKSNP_003738.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..91
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..173 3/12 (25%)
ANK 1. /evidence=ECO:0000255 181..209 8/30 (27%)
ANK 208..322 CDD:238125 34/113 (30%)
ANK 2. /evidence=ECO:0000255 215..244 9/28 (32%)
ANK repeat 218..246 CDD:293786 9/27 (33%)
Ank_2 220..312 CDD:289560 29/91 (32%)
ANK repeat 248..279 CDD:293786 9/30 (30%)
ANK 3. /evidence=ECO:0000255 248..277 8/28 (29%)
ANK 276..455 CDD:238125 61/186 (33%)
ANK repeat 281..312 CDD:293786 11/30 (37%)
ANK 4. /evidence=ECO:0000255 281..310 11/28 (39%)
ANK 5. /evidence=ECO:0000255 335..364 7/31 (23%)
Ank_4 339..389 CDD:290365 17/52 (33%)
ANK 6. /evidence=ECO:0000255 368..397 15/28 (54%)
ANK repeat 371..399 CDD:293786 15/27 (56%)
Ank_2 373..465 CDD:289560 37/91 (41%)
ANK repeat 401..432 CDD:293786 12/30 (40%)
ANK 7. /evidence=ECO:0000255 401..430 11/28 (39%)
ANK repeat 434..465 CDD:293786 11/30 (37%)
ANK 8. /evidence=ECO:0000255 434..463 11/28 (39%)
ANK 9. /evidence=ECO:0000255 521..553 11/31 (35%)
ANK 523..639 CDD:238125 36/119 (30%)
ANK repeat 523..555 CDD:293786 12/31 (39%)
Ank_2 526..619 CDD:289560 31/92 (34%)
ANK repeat 557..588 CDD:293786 12/30 (40%)
ANK 10. /evidence=ECO:0000255 557..586 11/28 (39%)
ANK repeat 590..619 CDD:293786 8/28 (29%)
ANK 11. /evidence=ECO:0000255 590..619 8/28 (29%)
Ank_2 595..714 CDD:289560 32/130 (25%)
ANK 12. /evidence=ECO:0000255 621..647 6/29 (21%)
ANK 13. /evidence=ECO:0000255 649..679 8/37 (22%)
ANK 676..801 CDD:238125 48/158 (30%)
ANK 14. /evidence=ECO:0000255 683..712 10/28 (36%)
ANK repeat 686..714 CDD:293786 10/27 (37%)
Ank_2 688..780 CDD:289560 40/124 (32%)
ANK repeat 716..747 CDD:293786 13/30 (43%)
ANK 15. /evidence=ECO:0000255 716..745 13/28 (46%)
ANK repeat 749..780 CDD:293786 16/63 (25%)
ANK 16. /evidence=ECO:0000255 749..778 16/61 (26%)
ANK 17. /evidence=ECO:0000255 782..810 8/28 (29%)
Ank_4 803..857 CDD:290365 11/53 (21%)
ANK 829..953 CDD:238125 44/145 (30%)
ANK repeat 836..867 CDD:293786 13/30 (43%)
ANK 18. /evidence=ECO:0000255 836..865 13/28 (46%)
Ank_2 841..933 CDD:289560 36/91 (40%)
ANK repeat 869..900 CDD:293786 11/30 (37%)
ANK 19. /evidence=ECO:0000255 869..898 11/28 (39%)
ANK repeat 902..933 CDD:293786 14/30 (47%)
ANK 20. /evidence=ECO:0000255 902..931 14/28 (50%)
ANK 21. /evidence=ECO:0000255 935..964 9/50 (18%)
SAM_tankyrase1,2 1024..1089 CDD:188923 12/96 (13%)
SAM 1030..1087 CDD:197735 11/88 (13%)
tankyrase_like 1091..1313 CDD:238718 42/232 (18%)
PARP 1105..1308 CDD:279038 38/213 (18%)
AnkNP_001162819.1 ANK 67..192 CDD:238125 36/126 (29%)
ANK repeat 72..103 CDD:293786 10/32 (31%)
Ank_2 77..167 CDD:289560 29/89 (33%)
ANK repeat 105..136 CDD:293786 9/30 (30%)
ANK repeat 138..169 CDD:293786 11/30 (37%)
ANK 204..320 CDD:238125 42/115 (37%)
ANK repeat 204..231 CDD:293786 6/26 (23%)
Ank_2 205..295 CDD:289560 32/89 (36%)
ANK repeat 233..264 CDD:293786 15/30 (50%)
ANK repeat 266..295 CDD:293786 11/28 (39%)
ANK 294..419 CDD:238125 43/148 (29%)
ANK repeat 299..330 CDD:293786 11/30 (37%)
Ank_4 300..353 CDD:290365 18/58 (31%)
ANK repeat 332..363 CDD:293786 10/36 (28%)
Ank_2 337..428 CDD:289560 33/114 (29%)
ANK 360..485 CDD:238125 42/147 (29%)
ANK repeat 365..395 CDD:293786 14/47 (30%)
ANK repeat 398..427 CDD:293786 11/28 (39%)
ANK repeat 431..462 CDD:293786 8/30 (27%)
Ank_2 436..526 CDD:289560 21/94 (22%)
ANK repeat 464..494 CDD:293786 9/34 (26%)
ANK 491..616 CDD:238125 37/126 (29%)
ANK repeat 496..527 CDD:293786 6/30 (20%)
Ank_2 501..592 CDD:289560 30/92 (33%)
ANK repeat 529..560 CDD:293786 11/31 (35%)
ANK 557..682 CDD:238125 38/124 (31%)
ANK repeat 562..590 CDD:293786 13/27 (48%)
Ank_5 582..636 CDD:290568 9/53 (17%)
ANK repeat 595..625 CDD:293786 5/29 (17%)
ANK repeat 628..657 CDD:293786 11/28 (39%)
Ank_2 633..723 CDD:289560 36/112 (32%)
ANK repeat 661..691 CDD:293786 8/29 (28%)
ANK 692..812 CDD:238125 44/142 (31%)
ANK repeat 693..724 CDD:293786 14/53 (26%)
Ank_2 698..788 CDD:289560 36/89 (40%)
ANK repeat 726..755 CDD:293786 11/28 (39%)
ANK repeat 759..788 CDD:293786 14/28 (50%)
ZU5 930..1034 CDD:128514 16/103 (16%)
Death_ank 1439..1521 CDD:260029
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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