DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDE5A and Pde11

DIOPT Version :9

Sequence 1:NP_001074.2 Gene:PDE5A / 8654 HGNCID:8784 Length:875 Species:Homo sapiens
Sequence 2:NP_001286044.1 Gene:Pde11 / 35107 FlyBaseID:FBgn0085370 Length:1451 Species:Drosophila melanogaster


Alignment Length:1011 Identity:428/1011 - (42%)
Similarity:566/1011 - (55%) Gaps:182/1011 - (18%)


- Green bases have known domain annotations that are detailed below.


Human     4 AGPSFGQQRQQQQPQQQK------------QQQRDQD----SVEAWLDDHWDFTFSYFVRKATRE 52
            |.|...||.|.|||.|.:            |..|..|    .:|||||::.:|...||:|||||:
  Fly   157 ATPQQQQQYQVQQPYQYQYQHHYHHQANSPQHHRPYDPEHARMEAWLDENQEFVQDYFIRKATRQ 221

Human    53 MVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPG----TPTRKISASEFDRP--LR 111
            .|:||...  |......:.:     |.:.|...:.:..:|..|    ||.|||||.||:|.  |:
  Fly   222 TVDAWLVS--HATSAGNDVV-----SSTSPTHANGQTSSSRGGSGATTPVRKISAHEFERGGLLK 279

Human   112 PIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRL------------------------ 152
            || |...:||.:|||         :.||..:...|..||.|                        
  Fly   280 PI-VNTIDGTPTFLS---------IGPPMDNGSVGGSCSNLQNVGGVVAGQYQYNHQQHHHNHAH 334

Human   153 ----------------------------------------------------------------- 152
                                                                             
  Fly   335 LHHSQHSHYQAGGAVGSSSLGSTGGASGAGGAPSLGGSGGAGNGHQYPYYHCHQRPQRLSRNELK 399

Human   153 --------LELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLV---CEDSSN-DKFLISRLF 205
                    .||||||.:.|:|..|||||..::..|::|||.|||||   |..... .|.|:|:||
  Fly   400 QLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLKKCLVSKLF 464

Human   206 DVAEGSTLEEV-SNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCM 269
            ||...||:||: ..:.:|:.|..||.||||..|||:||.|||:|.|||.|:|.:|||:|:::|||
  Fly   465 DVCPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDERFNCEIDSLTGYRTKALLCM 529

Human   270 PIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLL 334
            |||:...:|:||||.|||.  ||..|:|.|||.|::||.||||.|.||||||.|.||.|||||||
  Fly   530 PIKDSSGDVIGVAQVINKM--NGECFSEIDEKVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLL 592

Human   335 DLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEEL-EKSSDTL 398
            |||.:|||||.::|.::.:|...:.|.:|.|:..|.:|.|....|||.||..|..:| |:.:.:.
  Fly   593 DLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVHEADKGSFSRVFDFEANDLSEEEATSR 657

Human   399 TREHDAN-KINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCI--RSLLCTPIKNGK 460
            |..:::. .||.....:|..|.|.:|:|:..:|.||..:.:     ...|.  ||:||..||| .
  Fly   658 TSPYESRFPINIGITGHVATTGETVNVPNAYEDDRFDASVD-----ENSCFKHRSILCMAIKN-S 716

Human   461 KNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEV 525
            ..::|||.||:||..|     ..|.:|||.|:|||.||||:||.||.|||....|||||.|||||
  Fly   717 LGQIIGVIQLINKFNE-----LDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEV 776

Human   526 LSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQM 590
            |||||||..:|...|:.|.   ||||...::.||.|.|....|.:|....:|||.||:.|:.|.:
  Fly   777 LSYHASATMDEAHRLRRLR---VPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHI 838

Human   591 KHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDL 655
            .:||||||:|||||||| ||.|||||||||.||.|||.|...:......::|.|||:|..|.|||
  Fly   839 DYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDL 902

Human   656 DHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI 720
            ||||.|||:..::..||||||..|.|||||||||||||||||||||:.||.::|...:::::.||
  Fly   903 DHRGTNNSFQIKASSPLAQLYSTSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAI 967

Human   721 LATDLALYIKRRGEFFELIRK--NQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVA 783
            |:||||:|.|:||.|.|.:.:  :.:..|:|  :.|..||.||.||||||||||.|::|:|:||:
  Fly   968 LSTDLAVYFKKRGPFLESVSQPTSYWVAEEP--RALLRAMSMTVCDLSAITKPWEIEKRVADLVS 1030

Human   784 TEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRK 848
            :|||:|||.|::||||.|.|:|||||::::|.|||.|||:|||.:|||...:|:...||::|.|.
  Fly  1031 SEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRD 1095

Human   849 NRQKWQALA----------------EQQEKMLINGE 868
            ||..|..||                :||:.::.||:
  Fly  1096 NRGHWIDLADVVKTKTSQDQEPEEEQQQQNVISNGD 1131

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDE5ANP_001074.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..29 12/40 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 78..102 8/27 (30%)
GAF 164..321 CDD:214500 86/161 (53%)
GAF 347..513 CDD:214500 62/169 (37%)
PDEase_I 612..847 CDD:278654 132/236 (56%)
Pde11NP_001286044.1 GAF 420..582 CDD:214500 88/163 (54%)
GAF 611..762 CDD:214500 60/161 (37%)
PDEase_I 859..1094 CDD:278654 132/236 (56%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154154
Domainoid 1 1.000 109 1.000 Domainoid score I6352
eggNOG 1 0.900 - - E1_KOG3689
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H842
Inparanoid 1 1.050 702 1.000 Inparanoid score I673
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D114875at33208
OrthoFinder 1 1.000 - - FOG0002593
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100960
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4714
SonicParanoid 1 1.000 - - X5988
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.690

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