Protein Alignment DDX3Y and DED1

DIOPT Version :10

• Sequence 1: NP_004651.2
• Gene: DDX3Y / 8653
• HGNCID: 2699
• Length: 660
• Species: Homo sapiens
• Sequence 2: NP_014847.3
• Gene: DED1 / 854379
• SGDID: S000005730
• Length: 604
• Species: Saccharomyces cerevisiae
• Alignment Length: 664
• Identity: 329/664 - (49%)
• Similarity: 431/664 - (64%)
• Gaps: 78/664 - (11%)

Human    11 ELDQQLANLDLNSEKQSGGASTASKGRYIPPHLRNREAS----KGFHDKDSSGWSCSKDKDAYSS 71
            ||.:|:.||.:|...::|         |:|||||.:..|    ...::.::.|::..:...::.|
Yeast     3 ELSEQVQNLSINDNNENG---------YVPPHLRGKPRSARNNSSNYNNNNGGYNGGRGGGSFFS 58

Human    72 FGSRDSRGKPGYFSERGSGSRGRFDDRGRSDYDGIGNRERPGFGRFERSGHSRWCD-KSVEDDWS 135
            ...|...|..|:|.....|||    ..|||.                    .||.| |.|
Yeast    59 NNRRGGYGNGGFFGGNNGGSR----SNGRSG--------------------GRWIDGKHV----- 94

Human   136 KPLPPSERLEQELF------SGGNTGINFEKYDDIPVEATGSNCPPHIENFSDIDMGEIIMGNIE 194
             |.|.:|:.|..:|      :..::||||:.||||||:|:|.:.|..|..|:...:..:::.||:
Yeast    95 -PAPRNEKAEIAIFGVPEDPNFQSSGINFDNYDDIPVDASGKDVPEPITEFTSPPLDGLLLENIK 158

Human   195 LTRYTRPTPVQKHAIPIIKGKRDLMACAQTGSGKTAAFLLPILSQIYTDGPGEALKAVKENGRYG 259
            |.|:|:||||||:::||:...||||||||||||||..||.|:||:.:..||.   ...:..|.:.
Yeast   159 LARFTKPTPVQKYSVPIVANGRDLMACAQTGSGKTGGFLFPVLSESFKTGPS---PQPESQGSFY 220

Human   260 RRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGR 324
            :||.||.::::|||||||.||::||:||:|||.|:.||||||:.||.|:|::||||.||||||||
Yeast   221 QRKAYPTAVIMAPTRELATQIFDEAKKFTYRSWVKACVVYGGSPIGNQLREIERGCDLLVATPGR 285

Human   325 LVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQM 389
            |.|::|||||.|...|||||||||||||||||||||.|||...|.|.|.|.|:|||||||.:||.
Yeast   286 LNDLLERGKISLANVKYLVLDEADRMLDMGFEPQIRHIVEDCDMTPVGERQTLMFSATFPADIQH 350

Human   390 LARDFLDEYIFLAVGRVGSTSENITQKVVWVEDLDKRSFLLDILGATGSDSLTLVFVETKKGADS 454
            ||||||.:||||:|||||||||||||||::||:.||:|.|||:|.|: :|.|||:|||||:.||.
Yeast   351 LARDFLSDYIFLSVGRVGSTSENITQKVLYVENQDKKSALLDLLSAS-TDGLTLIFVETKRMADQ 414

Human   455 LEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVRHVINFDLPSD 519
            |.|||..:.:..|:|||||:|.:||.||..||||.:.:|||||||||||||.||.||||:|||||
Yeast   415 LTDFLIMQNFRATAIHGDRTQSERERALAAFRSGAATLLVATAVAARGLDIPNVTHVINYDLPSD 479

Human   520 IEEYVHRIGRTGRVGNLGLATSFFNEKNMNITKDLLDLLVEAKQEVPSWLENMAYEHHYKGGSRG 584
            :::||||||||||.||.||||:|||.:|.||.|.|.::|.||.|||||:|::...       |..
Yeast   480 VDDYVHRIGRTGRAGNTGLATAFFNSENSNIVKGLHEILTEANQEVPSFLKDAMM-------SAP 537

Human   585 RSKSNRFSGGFGA---RDYRQSSGSSSSGFGASRG-SSSRSGGGGYG-NSRGFGGGGYGGFYNSD 644
            .|:||...||||.   ||||::.|:|:.|:|:||. .:|..||.|:| :|:..|.|..||..||
Yeast   538 GSRSNSRRGGFGRNNNRDYRKAGGASAGGWGSSRSRDNSFRGGSGWGSDSKSSGWGNSGGSNNS- 601

Human   645 GYGGNYNSQGVDWW 658
                       .||
Yeast   602 -----------SWW 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX3Y	NP_004651.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..121		26/113 (23%)
		DEADc_DDX3	158..408	CDD:350809	150/249 (60%)
		Q motif	178..206		10/27 (37%)
		DEAD box	345..348		2/2 (100%)
		SF2_C_DEAD	413..543	CDD:350174	85/129 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	578..625		21/50 (42%)
DED1	NP_014847.3	SrmB	141..526	CDD:440279	244/388 (63%)