Protein Alignment DDX3Y and laf-1

DIOPT Version :10

• Sequence 1: NP_004651.2
• Gene: DDX3Y / 8653
• HGNCID: 2699
• Length: 660
• Species: Homo sapiens
• Sequence 2: NP_001254859.1
• Gene: laf-1 / 190611
• WormBaseID: WBGene00002244
• Length: 708
• Species: Caenorhabditis elegans
• Alignment Length: 723
• Identity: 354/723 - (48%)
• Similarity: 455/723 - (62%)
• Gaps: 104/723 - (14%)

Human    22 NSEKQSGGASTAS---KGRYIPPHLRNRE------ASKGFHDK---------------DSSGWSC 62
            :::..:||:..|:   .|||:|||||..:      ||.|..|:               ...|...
 Worm     3 SNQSNNGGSGNAALNRGGRYVPPHLRGGDGGAAAAASAGGDDRRGGAGGGGYRRGGGNSGGGGGG 67

Human    63 SKDKDAYSSFGSRDSR-GKPGYFSER------------GSGSRGRFDDRG----------RSDYD 104
            ..|:....:...||:| |..||..:|            |.|:||..::||          |.| .
 Worm    68 GYDRGYNDNRDDRDNRGGSGGYGRDRNYEDRGYNGGGGGGGNRGYNNNRGGGGGGYNRQDRGD-G 131

Human   105 GIGNRERPGFGRFERSGHSRWCDKSVEDD------------WSK-PLPPS-------------ER 143
            |..|..|.|:...:....:|...:|..:|            |:. ..|||             ||
 Worm   132 GSSNFSRGGYNNRDEGSDNRGSGRSYNNDRRDNGGDGQNTRWNNLDAPPSRGTSKWENRGARDER 196

Human   144 LEQELFSGGNTGINFEKYDDIPVEATGSNCPPHIENFSDIDMGEIIMGNIELTRYTRPTPVQKHA 208
            :|||||||..:||||:||::|||||||.:.|..|..|||:.:.|.|..||:...|.|||||||::
 Worm   197 IEQELFSGQLSGINFDKYEEIPVEATGDDVPQPISLFSDLSLHEWIEENIKTAGYDRPTPVQKYS 261

Human   209 IPIIKGKRDLMACAQTGSGKTAAFLLPILSQIYTDGPGEALKAVKENGRYGRRKQYPISLVLAPT 273
            ||.::|.||||:|||||||||||||:|:::.|..|||....::|..:|  ||:||||.:|||:||
 Worm   262 IPALQGGRDLMSCAQTGSGKTAAFLVPLVNAILQDGPDAVHRSVTSSG--GRKKQYPSALVLSPT 324

Human   274 RELAVQIYEEARKFSYRSRVRPCVVYGGAD-IGQQIRDLERGCHLLVATPGRLVDMMERGKIGLD 337
            |||::||:.|:|||:||:.:...::|||.: ...||..|..|||:|:||||||:|:|::|.||::
 Worm   325 RELSLQIFNESRKFAYRTPITSALLYGGRENYKDQIHKLRLGCHILIATPGRLIDVMDQGLIGME 389

Human   338 FCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDE-YIFL 401
            .|:||||||||||||||||||||:|||.:.||.|..|.|.|||||||||||:||:|||.| |:||
 Worm   390 GCRYLVLDEADRMLDMGFEPQIRQIVECNRMPSKEERITAMFSATFPKEIQLLAQDFLKENYVFL 454

Human   402 AVGRVGSTSENITQKVVWVEDLDKRSFLLDILGATGSDSLTLVFVETKKGADSLEDFLYHEGYAC 466
            ||||||||||||.||:||||:.:|||:|:|:|.|||..||||||||||:||..|..:|..:.|..
 Worm   455 AVGRVGSTSENIMQKIVWVEEDEKRSYLMDLLDATGDSSLTLVFVETKRGASDLAYYLNRQNYEV 519

Human   467 TSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVRHVINFDLPSDIEEYVHRIGRTG 531
            .:||||..|.:||:.|..||:|.:|||||||||||||||.||:||||:|||||::||||||||||
 Worm   520 VTIHGDLKQFEREKHLDLFRTGTAPILVATAVAARGLDIPNVKHVINYDLPSDVDEYVHRIGRTG 584

Human   532 RVGNLGLATSFFNEKNMNITKDLLDLLVEAKQEVPSWLENMAYEHHYKGGSRGRSKSNRFSG-GF 595
            ||||:||||||||:||.||.::|:||:|||.||:|.|||.|:.:....||.|||  ..|.:| .|
 Worm   585 RVGNVGLATSFFNDKNRNIARELMDLIVEANQELPDWLEGMSGDMRSGGGYRGR--GGRGNGQRF 647

Human   596 GARDYRQSSGSSSSGFGASRGSSSRSGGGGYGNSRGFGGGGY----GGFYNSDGYGGNYNSQ--- 653
            |.||:|...||.             :||||.|...||||||.    ||.:.|.|.||....|
 Worm   648 GGRDHRYQGGSG-------------NGGGGNGGGGGFGGGGQRSGGGGGFQSGGGGGRQQQQQQR 699

Human   654 ---GVDWW 658
               ..|||
 Worm   700 AQPQQDWW 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX3Y	NP_004651.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..121		36/145 (25%)
		DEADc_DDX3	158..408	CDD:350809	151/251 (60%)
		Q motif	178..206		13/27 (48%)
		DEAD box	345..348		2/2 (100%)
		SF2_C_DEAD	413..543	CDD:350174	87/129 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	578..625		16/47 (34%)
laf-1	NP_001254859.1	SrmB	233..619	CDD:440279	247/387 (64%)