DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SOCS1 and socs1a

DIOPT Version :9

Sequence 1:	NP_003736.1	Gene:	SOCS1 / 8651	HGNCID:	19383	Length:	211	Species:	Homo sapiens
Sequence 2:	NP_001003467.1	Gene:	socs1a / 445073	ZFINID:	ZDB-GENE-040801-205	Length:	201	Species:	Danio rerio

Alignment Length:	213	Identity:	89/213 - (41%)
Similarity:	132/213 - (61%)	Gaps:	20/213 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     1 MVAH-----NQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRS 60
            ||||     ||...|..|||.|          ||....:..:|||     .:.....|||:.|..
Zfish     1 MVAHSSVEGNQGIEDRQVSTEA----------SSDVFQSQRSRPR-----QSTVAFQTHFKPFNY 50

Human    61 HADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTS 125
            ..|::.|:..:::|:..||||||::|..||.:|:.|.|||||:|||||.:.||.||.|..:||.|
Zfish    51 ARDFKIISNTTSMLEESGFYWGPMTVEEAHLKLKKESVGTFLIRDSRQSDVFFTLSYKAQNGPVS 115

Human   126 IRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVATVGREN 190
            ||::|:..:|.|.||:||||.||:|||||:::|::.|..|.|:..|:.||:|||::|:.....::
Zfish   116 IRINFKNSKFSLTGSKESFDSLFKLLEHYISSPKKGLIRPCRKEPVQSLQQLCRRQIMERCDGKD 180

Human   191 LARIPLNPVLRDYLSSFP 208
            :..||:.|:|:|:|.:||
Zfish   181 IDCIPVQPILKDFLHAFP 198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SOCS1	NP_003736.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		16/56 (29%)
		Kinase inhibitory region (KIR)	55..66		3/10 (30%)
		Extended SH2 subdomain (ESS)	67..78		2/10 (20%)
		SH2_SOCS1	68..165	CDD:198245	50/96 (52%)
		SOCS_SOCS1	169..211	CDD:239704	15/40 (38%)
		Interaction with Elongin BC complex. /evidence=ECO:0000250	173..182		5/8 (63%)
socs1a	NP_001003467.1	SH2_SOCS1	58..155	CDD:198245	50/96 (52%)
socs1a	NP_001003467.1	SOCS	161..198	CDD:295349	13/36 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194332585
Domainoid	1	1.000	102	1.000	Domainoid score	I25556
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2776
Inparanoid	1	1.050	168	1.000	Inparanoid score	I11433
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48105
OrthoDB	1	1.010	-	-		D1135696at2759
OrthoFinder	1	1.000	-	-		FOG0010395
OrthoInspector	1	1.000	-	-		oto48122
orthoMCL	1	0.900	-	-		OOG6_118934
Panther	1	1.100	-	-	O	PTHR10155
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10589
SonicParanoid	1	1.000	-	-		X7840
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	19	19.300