DRSC/TRiP Functional Genomics Resources

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Protein Alignment NUMB and CG8312

DIOPT Version :10

Sequence 1:NP_001005743.1 Gene:NUMB / 8650 HGNCID:8060 Length:651 Species:Homo sapiens
Sequence 2:NP_649918.1 Gene:CG8312 / 41163 FlyBaseID:FBgn0037720 Length:866 Species:Drosophila melanogaster


Alignment Length:517 Identity:97/517 - (18%)
Similarity:160/517 - (30%) Gaps:186/517 - (35%)


- Green bases have known domain annotations that are detailed below.


Human    25 W-QTDEEGVRTGKCSFPVKYLGHVEVDESRG-----------------MHICEDAVKRLKAERKF 71
            | :|....:.|....|.|.|||:|....::.                 .|...|.:.|||     
  Fly   249 WRRTHSVDISTPDPEFKVSYLGNVLTGWAKAGEGCVEKQLNTLWRNYTQHSKPDVIMRLK----- 308

Human    72 FKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTT 136
                              |.|.||:....:..  :.:....::::|...:|:.|.|.:|.|    
  Fly   309 ------------------VCASGLKATTRQHG--LTEYWAHRITYCCAPKNYPRVFCWIYR---- 349

Human   137 RRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTAT 201
                        ..|.:|.|.:.|....|.:.|..::    :..|.        ||   .:.:|.
  Fly   350 ------------HEGRKLKHELRCHAVLCSKEKIAQD----ICDTL--------RE---NLESAL 387

Human   202 EQAEREEIMKQ---------MQDAKKAETDKIVVGSSVAPGNTAP----SPSSPTSPTSDATTSL 253
            .:.:||:|:||         :.|.......||::  ||...|..|    |.|:|.....:.....
  Fly   388 REFKREKILKQNARLSLANAVYDNPSLPRRKIML--SVGGNNYRPPLERSKSAPKLMAIEEAIGE 450

Human   254 E-------MNNPHAIP---------------RRHAPIEQLARQGSFRGF-PALSQKMSPFKRQLS 295
            |       .|.|..:|               ||......:.|.|..:.| |..|..|:       
  Fly   451 EEGDEIEDTNEPEMMPCCQKDSLYPAMTLGRRRCRRGHSIRRTGKIQSFSPCCSSHMA------- 508

Human   296 LRINELP----STMQR------------------KTDFPIKN-------------------AVPE 319
               .|||    .||..                  |.|..:.|                   ::.|
  Fly   509 ---KELPQEETKTMAAAGSSANDGSDSDDFEKLLKFDTTLSNELLPYFDMQLHKNSSQSMVSLSE 570

Human   320 V-EGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQSPTFQANG-----TDSAFHVLAK 378
            : |.|.|.:|.|.:..::..:.||..:::    :...|.||:.....::|     .|:..|..  
  Fly   571 LKEEEGEPLSLLPTINSDPSADPEADYNA----EDHDVTAPRRSGVCSDGEEDFLDDADDHYF-- 629

Human   379 PAHTALAPVAMPVRETNPWAHAPDAAN--------KEIAATCSGTEWGQSSGAASPGLFQAG 432
             .|.|:  :.|..|.:.....|.|..:        ..|::..|.:....:|.||..|..|.|
  Fly   630 -RHAAM--LTMLHRSSMRKMRAADQTSLKYRHQTQSSISSNASSSTTASTSAAAGGGSAQQG 688

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NUMBNP_001005743.1 PTB_Numb 23..168 CDD:241298 29/160 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 228..255 8/37 (22%)
NumbF 258..338 CDD:461874 24/137 (18%)
PRK10263 <343..>524 CDD:236669 20/103 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 419..483 6/14 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 623..651
CG8312NP_649918.1 PID_2 263..442 CDD:405418 46/236 (19%)
Blue background indicates that the domain is not in the aligned region.

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