DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NUMB and numb

DIOPT Version :10

Sequence 1:NP_001005743.1 Gene:NUMB / 8650 HGNCID:8060 Length:651 Species:Homo sapiens
Sequence 2:NP_523523.2 Gene:numb / 34263 FlyBaseID:FBgn0002973 Length:556 Species:Drosophila melanogaster


Alignment Length:591 Identity:240/591 - (40%)
Similarity:299/591 - (50%) Gaps:156/591 - (26%)


- Green bases have known domain annotations that are detailed below.


Human     1 MNKLRQ----SFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDA 61
            |::||:    ||||:|| .|||:|:|||||.|||.||:..|||.|||||.|||.|||||.:||:|
  Fly    42 MDRLRRSFRDSFRRRKD-RVPESSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEA 105

Human    62 VKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRA 126
            :|.|:..|           ::.|:.:|.||.|||||||::||.||||||||||||||||||.:|.
  Fly   106 LKVLRQSR-----------RRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHERG 159

Human   127 FSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTR 191
            |||||||||||||:||.|:|.||:|||||||||||||.||||||:|:||||||.|||...:||||
  Fly   160 FSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNSTFTR 224

Human   192 EGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMN 256
            .||||..|.||         ::..|.....::.|.|    ||:..|.|.:.|         ::..
  Fly   225 TGSFRQQTLTE---------RLAMATVGTNERSVDG----PGSAMPGPPAAT---------VKPF 267

Human   257 NPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDF---------- 311
            ||.||.|.||....|.||.|||.....||  ||||||:|||||:|||...|:..|          
  Fly   268 NPFAIERPHATPNMLERQSSFRLSTIGSQ--SPFKRQMSLRINDLPSNADRQRAFLTAAAGNPMQ 330

Human   312 -PIKNAVPEVEGE----------------AESISSLCSQITNAFS--TPEDPF------------ 345
             |:::..|..|..                |:|:|.||.:::...|  |..|..            
  Fly   331 TPLRSVSPIAEVSPAKSAGADPLSAAAVAADSVSQLCQELSQGLSLLTQTDALLAAGEDLNFNNN 395

Human   346 ------------------SSAPMTKPVTV-VAPQSPTFQANGTDSAFHVLAKPAHTALAPVAMP- 390
                              |.||.|..||. ||..:||:|...:.|.    ::...:......:| 
  Fly   396 RSINQNIIAAEKQVQHVHSYAPPTAQVTPRVASTTPTYQTLHSQSP----SRSEQSIETSTELPN 456

Human   391 --------VRETNPWAHAPD----AANKEIAAT-CSGTEWGQSSGAASPGLFQAGHRRTPSEADR 442
                    ||.|:|  .||.    .||...|.| .|||      |||..|    |....|.:|: 
  Fly   457 AEQWLGHVVRSTSP--AAPKRPTYLANVGRAQTLASGT------GAAVGG----GGPDDPFDAE- 508

Human   443 WLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGVVPALQPAFVP 507
            |:..|          |:|..|.|.| |.|.||.| |.:....|.|::             |...|
  Fly   509 WVANV----------AAAKQLSPDL-PIPSTARS-PLARHSTNPFIS-------------PPKAP 548

Human   508 AQSYPV 513
            |||:.|
  Fly   549 AQSFQV 554

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NUMBNP_001005743.1 PTB_Numb 23..168 CDD:241298 97/144 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 228..255 5/26 (19%)
NumbF 258..338 CDD:461874 38/106 (36%)
PRK10263 <343..>524 CDD:236669 55/216 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 419..483 20/63 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 623..651
numbNP_523523.2 PTB_Numb 67..201 CDD:241298 97/144 (67%)
NumbF 269..374 CDD:461874 38/106 (36%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.