DRSC/TRiP Functional Genomics Resources

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Protein Alignment NCOA1 and tgo

DIOPT Version :10

Sequence 1:NP_003734.3 Gene:NCOA1 / 8648 HGNCID:7668 Length:1441 Species:Homo sapiens
Sequence 2:NP_731308.1 Gene:tgo / 41084 FlyBaseID:FBgn0264075 Length:642 Species:Drosophila melanogaster


Alignment Length:668 Identity:144/668 - (21%)
Similarity:231/668 - (34%) Gaps:210/668 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    10 DPANPDSHKR---KGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILK 71
            |.||....:|   :.:.|:     .|:|||.:...|:.||:::    :....:|:.||||..||:
  Fly     2 DEANIQDKERFASRENHCE-----IERRRRNKMTAYITELSDM----VPTCSALARKPDKLTILR 57

Human    72 KTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVF 135
            ..|..   ||.:....:|:.|...|...       :..:.|..|:|||.|||.|||:|: ||:::
  Fly    58 MAVAH---MKALRGTGNTSSDGTYKPSF-------LTDQELKHLILEAADGFLFVVSCDSGRVIY 112

Human   136 VSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG---VPWPQEATRRNSHT--- 194
            ||::||..|.|.|.:...||:|..:|..|..:..:.|..:...|.   :.......::..|.   
  Fly   113 VSDSVTPVLNYTQSDWYGTSLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSM 177

Human   195 ---------FNCRML---IHP------------------PDEPGTENQEACQRYEVMQC--FTVS 227
                     |.|||.   ::|                  |...||       .|.|:.|  :..:
  Fly   178 RLSMGARRGFICRMRVGNVNPESMVSGHLNRLKQRNSLGPSRDGT-------NYAVVHCTGYIKN 235

Human   228 QPKS-------IQEDGEDFQS--CLICIARRLPRPPAITGV------ESFMTKQDTTGKIISIDT 277
            .|.:       ::.|.:|..|  ||:.|.|......|...:      ..|:|:....||...:|.
  Fly   236 WPPTDMFPNMHMERDVDDMSSHCCLVAIGRLQVTSTAANDMSGSNNQSEFITRHAMDGKFTFVDQ 300

Human   278 SSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMT----------RGTASSPSYRFI- 331
            ..|...|.|..| |:.|..|.||.|:  :.|:.::.|.:|:.          |..|.:..|.:: 
  Fly   301 RVLNILGYTPTE-LLGKICYDFFHPE--DQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLR 362

Human   332 ------LNDGT----------------------MLSAHTKCKLCYPQSPDMQPFIMGIHIIDREH 368
                  ||..|                      ..:|||..::...|..:...::.....:|...
  Fly   363 TQAYAFLNPYTDEVEYIVCTNSSGKTMHGAPLDAAAAHTPEQVQQQQQQEQHVYVQAAPGVDYAR 427

Human   369 SGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSSDLHSSSHSN 433
            ..|:|            |..:.|..:...|.:|..:..|.          .:||...        
  Fly   428 RELTP------------VGSATNDGMYQTHMLAMQAPTPQ----------QQQQQQQ-------- 462

Human   434 SSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTGIS-LAQFMSPRRQVTSGL 497
                      .|||            |.:.....:.:..:||....|.| ||:.  |:    ||.
  Fly   463 ----------RPGS------------AQTTPVGYTYDTTHSPYSAGGPSPLAKI--PK----SGT 499

Human   498 ATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTSLQGMNEG---PNNSVGFSASSP 559
            :..|..||                :.:|.....:.....|||      ||   ...|...|.|.|
  Fly   500 SPTPVAPN----------------SWAALRPQQQQQQQQPVT------EGYQYQQTSPARSPSGP 542

Human   560 VLRQMSSQNSPSRLNIQP 577
            ...|:|:.|. :|...||
  Fly   543 TYTQLSAGNG-NRQQAQP 559

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NCOA1NP_003734.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39 9/31 (29%)
bHLH-PAS_NCoA1_SRC1 27..87 CDD:381518 17/59 (29%)
LXXLL motif 1 46..50 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 83..105 3/21 (14%)
LXXLL motif 2 112..116 1/3 (33%)
PAS 120..213 CDD:238075 32/129 (25%)
PAS_11 259..370 CDD:464214 29/155 (19%)
Interaction with STAT3. /evidence=ECO:0000269|PubMed:11773079 361..567 38/209 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 368..443 9/74 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 457..477 3/19 (16%)
NCOA_u2 468..590 CDD:465223 28/114 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 561..585 6/17 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 597..626
SRC-1 629..708 CDD:462615
LXXLL motif 3 633..637
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 662..723
LXXLL motif 4 690..694
DUF4927 741..818 CDD:465083
LXXLL motif 5 749..753
Interaction with CREBBP 781..988
LXXLL motif 6 913..917
Nuc_rec_co-act 924..969 CDD:462608
Med15 974..>1287 CDD:312941
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1143..1188
DUF1518 1149..1205 CDD:462174
DUF1518 1212..1268 CDD:462174
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1409..1441
LXXLL motif 7 1435..1439
tgoNP_731308.1 bHLH-PAS_ARNT 9..74 CDD:381517 20/76 (26%)
PAS 90..154 CDD:214512 26/63 (41%)
PAS_11 282..384 CDD:464214 24/104 (23%)
Blue background indicates that the domain is not in the aligned region.

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