Protein Alignment NCOA1 and cyc

DIOPT Version :10

• Sequence 1: NP_003734.3
• Gene: NCOA1 / 8648
• HGNCID: 7668
• Length: 1441
• Species: Homo sapiens
• Sequence 2: NP_524168.2
• Gene: cyc / 40162
• FlyBaseID: FBgn0023094
• Length: 413
• Species: Drosophila melanogaster
• Alignment Length: 409
• Identity: 91/409 - (22%)
• Similarity: 159/409 - (38%)
• Gaps: 108/409 - (26%)

Human     6 DSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKIL 70
            |........|.::::..      |..|||||::.|.|:.||:.::....    ::..|.||..:|
  Fly    19 DEEKSARTSDENRKQNH------SEIEKRRRDKMNTYINELSSMIPMCF----AMQRKLDKLTVL 73

Human    71 KKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIV 134
            :..|..::.::...........|.:.|.:|.        :.|..::|:|.:||.|||.|: |||:
  Fly    74 RMAVQHLRGIRGSGSLHPFNGSDYRPSFLSD--------QELKMIILQASEGFLFVVGCDRGRIL 130

Human   135 FVSENVTSYLGYNQEELMNTSVYSILHVGDHAEF-----------------------VKNLLPKS 176
            :||::|:|.|...|.:|:..|.:.:||..|..:.                       ||..:|:|
  Fly   131 YVSDSVSSVLNSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQS 195

Human   177 LVNGVPWPQEATRRNSHTFNCRMLIHP------PDEPGTENQEAC-----------QRYEVMQCF 224
            |....|    ..||   :|.|||.:..      .:|..|.:....           .:|.|:||
  Fly   196 LCRLCP----GARR---SFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQC- 252

Human   225 TVSQPKS---IQEDGEDFQ--------SCLICIAR------------RLPRPPAITGVESFMTKQ 266
             ....||   |:::.:|..        |||:.|.|            .|...|.|..| .|:::.
  Fly   253 -TGYLKSWTPIKDEDQDADSDEQTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHV-LFISRH 315

Human   267 DTTGKIISIDTSSLRAAGRTGW--EDLVRKCIYAFFQPQG-----REPSYARQLFQEVMTRGTAS 324
            ...||.:.||.   ||....|:  ::::....|.:|..:.     .......|:.::|.|:
  Fly   316 SGEGKFLFIDQ---RATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQ---- 373

Human   325 SPSYRFILNDGTMLSAHTK 343
              .|||...|.:.:...::
  Fly   374 --VYRFRCKDNSYIQLQSE 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NCOA1	NP_003734.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39		8/32 (25%)
		bHLH-PAS_NCoA1_SRC1	27..87	CDD:381518	15/59 (25%)
		LXXLL motif 1	46..50		1/3 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	83..105		3/21 (14%)
		LXXLL motif 2	112..116		1/3 (33%)
		PAS	120..213	CDD:238075	34/122 (28%)
		PAS_11	259..370	CDD:464214	18/92 (20%)
		Interaction with STAT3. /evidence=ECO:0000269|PubMed:11773079	361..567
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	368..443
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	457..477
		NCOA_u2	468..590	CDD:465223
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	561..585
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	597..626
		SRC-1	629..708	CDD:462615
		LXXLL motif 3	633..637
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	662..723
		LXXLL motif 4	690..694
		DUF4927	741..818	CDD:465083
		LXXLL motif 5	749..753
		Interaction with CREBBP	781..988
		LXXLL motif 6	913..917
		Nuc_rec_co-act	924..969	CDD:462608
		Med15	974..>1287	CDD:312941
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1143..1188
		DUF1518	1149..1205	CDD:462174
		DUF1518	1212..1268	CDD:462174
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1409..1441
		LXXLL motif 7	1435..1439
cyc	NP_524168.2	bHLH_SF	31..92	CDD:469605	15/70 (21%)
		PAS	111..173	CDD:214512	22/61 (36%)
		PAS_11	311..411	CDD:464214	17/89 (19%)