Protein Alignment NCOA1 and Clk

DIOPT Version :10

• Sequence 1: NP_003734.3
• Gene: NCOA1 / 8648
• HGNCID: 7668
• Length: 1441
• Species: Homo sapiens
• Sequence 2: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Alignment Length: 233
• Identity: 51/233 - (21%)
• Similarity: 83/233 - (35%)
• Gaps: 81/233 - (34%)

Human   294 YAAQLAAM--QVSPGGKLLGLPQ-----------------GNLGAAVSPTSIHTD----KSTNSP 335
            |.|.|...  |:|....|.|||:                 ..:.|.|..|.:..:    .|||..
  Fly    35 YVATLREQLEQLSEEKTLEGLPRVTNAKVNEYYEKIEAVVSRIVAQVPHTEVSDEAFAKDSTNDS 99

Human   336 PPKSKDEVAQP----LNLSAKPKTSDGKS-PASPTSPHMPALRINSGAGPLKASVPAALASPSAR 395
            .||.:|:...|    |.....|.:|..:| .|.|:.|    :::::.|              .|:
  Fly   100 SPKVEDDTRTPNSPQLRRRIVPASSKEQSYDADPSKP----IKLDTAA--------------QAQ 146

Human   396 VSTIGYLNDHDAVTKAIQEARQMKEQLRREQQALDGKVAVVNSIGLSNCRTEKEKTTLESLTQQL 460
            |:....|.: |...:.:..|||:||:.:...|::.....:::|             |.|::.|.|
  Fly   147 VNKQRKLQE-DLTDEMVVLARQLKERSQMISQSVQNTEKILDS-------------TEEAIEQSL 197

Human   461 AVKQNEEGKFSHGMMDFNMSGDSDGSAGVSESRIYRES 498
            |                     |.|.|.|..::||.||
  Fly   198 A---------------------STGHATVRATKIYSES 214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NCOA1	NP_003734.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39
		bHLH-PAS_NCoA1_SRC1	27..87	CDD:381518
		LXXLL motif 1	46..50
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	83..105
		LXXLL motif 2	112..116
		PAS	120..213	CDD:238075
		PAS_11	259..370	CDD:464214	26/103 (25%)
		Interaction with STAT3. /evidence=ECO:0000269|PubMed:11773079	361..567		28/138 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	368..443		12/74 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	457..477		3/19 (16%)
		NCOA_u2	468..590	CDD:465223	8/31 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	561..585
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	597..626
		SRC-1	629..708	CDD:462615
		LXXLL motif 3	633..637
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	662..723
		LXXLL motif 4	690..694
		DUF4927	741..818	CDD:465083
		LXXLL motif 5	749..753
		Interaction with CREBBP	781..988
		LXXLL motif 6	913..917
		Nuc_rec_co-act	924..969	CDD:462608
		Med15	974..>1287	CDD:312941
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1143..1188
		DUF1518	1149..1205	CDD:462174
		DUF1518	1212..1268	CDD:462174
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1409..1441
		LXXLL motif 7	1435..1439
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	12/50 (24%)
		PAS	93..153	CDD:214512	17/77 (22%)
		PAS_11	265..368	CDD:464214