DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PTCH2 and ptc

DIOPT Version :9

Sequence 1:NP_003729.3 Gene:PTCH2 / 8643 HGNCID:9586 Length:1203 Species:Homo sapiens
Sequence 2:NP_523661.2 Gene:ptc / 35851 FlyBaseID:FBgn0003892 Length:1286 Species:Drosophila melanogaster


Alignment Length:1252 Identity:450/1252 - (35%)
Similarity:688/1252 - (54%) Gaps:126/1252 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    18 ARTAAPQILAGSL---KAPLWLRAYFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIE 79
            |:.|..||..|..   :..::||:.||..|.:||..:|:|.|||||:.:|......:||:.|.|.
  Fly    34 AQVALDQIDKGKARGSRTAIYLRSVFQSHLETLGSSVQKHAGKVLFVAILVLSTFCVGLKSAQIH 98

Human    80 TNLEQLWVEVGSRVSQELHYTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASK 144
            :.:.|||::.|.|:..||.||::.:||:.:.|.|:||||......::|.|:||..||:..:.|:.
  Fly    99 SKVHQLWIQEGGRLEAELAYTQKTIGEDESATHQLLIQTTHDPNASVLHPQALLAHLEVLVKATA 163

Human   145 VQVSLYGKSWDLNKICYKSGVPLIENGM--IERMIEKLFPCVILTPLDCFWEGAKLQG--GSAYL 205
            |:|.||...|.|..:|.....|..| |:  ||:::..|.||.|:|||||||||::|.|  .:..:
  Fly   164 VKVHLYDTEWGLRDMCNMPSTPSFE-GIYYIEQILRHLIPCSIITPLDCFWEGSQLLGPESAVVI 227

Human   206 PG-RPDIQWTNLDP--------EQLLEELGPFASLEGFRELLDKAQVGQAYVGRPCLHPDDLHCP 261
            || ...:.||.|:|        :::.||...| ..|...:.:.:|.:|..|:.:|||:|.:.:||
  Fly   228 PGLNQRLLWTTLNPASVMQYMKQKMSEEKISF-DFETVEQYMKRAAIGSGYMEKPCLNPLNPNCP 291

Human   262 PSAPNHHSRQAPNVAHELSGGCHGFSHKFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMSPR 326
            .:|||.:|.|.|:|...|||||:|::.|.|||.|||::||..|:..|.|.:|:||||...||:.:
  Fly   292 DTAPNKNSTQPPDVGAILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHLRKAQALQSVVQLMTEK 356

Human   327 QLYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFVQLAQEALPENA----SQQIHAFSSTTLDDIL 387
            ::|:.::.:|:.|.:||::|:|:.||.||||.|.:..::.|.:.:    :..|:.|||..|||||
  Fly   357 EMYDQWQDNYKVHHLGWTQEKAAEVLNAWQRNFSREVEQLLRKQSRIATNYDIYVFSSAALDDIL 421

Human   388 HAFSEVSAARVVGGYLLMLAYACVTMLRW-DCAQSQGSVGLAGVLLVALAVASGLGLCALLGITF 451
            ..||..||..:|.|..:.:.||..|:||| |..:.|.|||:|||||:..:.|:||||.|||||.|
  Fly   422 AKFSHPSALSIVIGVAVTVLYAFCTLLRWRDPVRGQSSVGVAGVLLMCFSTAAGLGLSALLGIVF 486

Human   452 NAATTQVLPFLALGIGVDDVFLLAHAFTEALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMA 516
            |||:|||:||||||:|||.:|:|..|:.|    :..:|:....|::.|.|::.::.:...:|..|
  Fly   487 NAASTQVVPFLALGLGVDHIFMLTAAYAE----SNRREQTKLILKKVGPSILFSACSTAGSFFAA 547

Human   517 ALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQ---VIQ 578
            |.:|:|||:.|.||||||:.....|.:|||||::|||||||...|.|:.||.......|   ...
  Fly   548 AFIPVPALKVFCLQAAIVMCSNLAAALLVFPAMISLDLRRRTAGRADIFCCCFPVWKEQPKVAPP 612

Human   579 ILPQELGDGTVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLVPPPSDPLGSELFSPGGSTR 643
            :||....:|             :...|.::.:.:.|.:         |..:||..:.....||:.
  Fly   613 VLPLNNNNG-------------RGARHPKSCNNNRVPL---------PAQNPLLEQRADIPGSSH 655

Human   644 DLLGQEEETRQKAACKSLPCARWNLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQ 708
            .|                  |.::||.||...:.|.|::|..|.:.::.|.|.|..|||.:|.:|
  Fly   656 SL------------------ASFSLATFAFQHYTPFLMRSWVKFLTVMGFLAALISSLYASTRLQ 702

Human   709 DGLALTDVVPRGTKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPP 773
            |||.:.|:||:.:.||.||.||.|.|..|.:..||||.|:|...|:.|.|.|..|..:..|:...
  Fly   703 DGLDIIDLVPKDSNEHKFLDAQTRLFGFYSMYAVTQGNFEYPTQQQLLRDYHDSFVRVPHVIKND 767

Human   774 ATQAPRTWLHYYRNWLQGIQAAFDQDWASGRITRHS-YRNGSEDGALAYKLLIQTGDAQEPLDFS 837
            ....|..||..:..||..:|..||:::..||:|:.. :.|.|.|..|||||::|||....|:|..
  Fly   768 NGGLPDFWLLLFSEWLGNLQKIFDEEYRDGRLTKECWFPNASSDAILAYKLIVQTGHVDNPVDKE 832

Human   838 QLTTRKLVDREGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLH--DKYDTTGENLRIP 900
            .:.|.:||:.:|:|....||..|:.|.::|.....|||...||.|.::.|  ::||     |:||
  Fly   833 LVLTNRLVNSDGIINQRAFYNYLSAWATNDVFAYGASQGKLYPEPRQYFHQPNEYD-----LKIP 892

Human   901 PAQPLEFAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCF- 964
            .:.||.:||.||.|.||..|:.....|...|....:....|:..||||.||:|||||:.||... 
  Fly   893 KSLPLVYAQMPFYLHGLTDTSQIKTLIGHIRDLSVKYEGFGLPNYPSGIPFIFWEQYMTLRSSLA 957

Human   965 LLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIG 1029
            ::..|:||....|| :||||:.|.|.|::|.:.....::||.|..|||||||||.|||:.|||:.
  Fly   958 MILACVLLAALVLV-SLLLLSVWAAVLVILSVLASLAQIFGAMTLLGIKLSAIPAVILILSVGMM 1021

Human  1030 VEFTVHVALGFLTTQGSRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVRYFFAALTV 1094
            :.|.|.::|||:|:.|:|..|...:::.:..|:..|.:::.:.:.||:.|.|:|::|:|...|.|
  Fly  1022 LCFNVLISLGFMTSVGNRQRRVQLSMQMSLGPLVHGMLTSGVAVFMLSTSPFEFVIRHFCWLLLV 1086

Human  1095 LTLLGLLHGLVLLPVLLSILGPPPEVIQMYKESPEILSPPAP---------------QGGGLRWG 1144
            :..:|..:.|::.|:|||::||..|::.:  |.|:.:|.|:|               ||.....|
  Fly  1087 VLCVGACNSLLVFPILLSMVGPEAELVPL--EHPDRISTPSPLPVRSSKRSGKSYVVQGSRSSRG 1149

Human  1145 A-------------SSSL------PQSFARVTTSMTVA---IHPP--PLPGAYIHPAPDEPPWSP 1185
            :             ..||      |||:....:|:.:.   .:.|  ..|.:|..|    ||...
  Fly  1150 SCQKSHHHHHKDLNDPSLTTITEEPQSWKSSNSSIQMPNDWTYQPREQRPASYAAP----PPAYH 1210

Human  1186 AATSSGNLSSRGPGPAT 1202
            .|.:..:...:|| |.|
  Fly  1211 KAAAQQHHQHQGP-PTT 1226

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTCH2NP_003729.3 2A060602 12..1142 CDD:273338 432/1166 (37%)
Sterol-sensing 418..570 CDD:289145 74/151 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1171..1203 9/32 (28%)
ptcNP_523661.2 2A060602 17..1134 CDD:273338 430/1153 (37%)
MMPL 454..598 CDD:304422 72/147 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154920
Domainoid 1 1.000 297 1.000 Domainoid score I1467
eggNOG 1 0.900 - - E1_KOG1935
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 866 1.000 Inparanoid score I426
Isobase 1 0.950 - 0 Normalized mean entropy S4544
OMA 1 1.010 - - QHG49297
OrthoDB 1 1.010 - - D1190129at2759
OrthoFinder 1 1.000 - - FOG0003078
OrthoInspector 1 1.000 - - otm41186
orthoMCL 1 0.900 - - OOG6_105508
Panther 1 1.100 - - O PTHR46022
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2737
SonicParanoid 1 1.000 - - X2446
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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