DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DCHS1 and CadN2

DIOPT Version :9

Sequence 1:NP_003728.1 Gene:DCHS1 / 8642 HGNCID:13681 Length:3298 Species:Homo sapiens
Sequence 2:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster


Alignment Length:2217 Identity:490/2217 - (22%)
Similarity:742/2217 - (33%) Gaps:662/2217 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   880 VRVLLDDVNDNSPAFPAPEDTVL----LPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG--G 938
            ||:.:.|.||:.|.|    |..|    :..|....:.:.|:.|.|.:...|.|...|   ||  |
  Fly    22 VRIGIADKNDSPPYF----DRFLYETEIDENADLQSTVLTVNAKDHNESTNIRYQIT---GGNIG 79

Human   939 GAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVV-VQDVGTRGLAPRFNS 1002
            .||.|..|||.:.:..||.....|.:||.|||    :..|.:::...|: |:||...  .|.|:.
  Fly    80 NAFAVQNTTGVIYVASPLDYETRPRYELRLEA----TRNRKNNYTTVVINVRDVNDN--PPVFDR 138

Human  1003 PTYRVDLPSGTTAGTQVLQVQAQAPDGG-----PITYHLAAEG------ASSPFGLEPQSGWLWV 1056
            .|||..:............:|..|.||.     .|.|.|..:|      |:|.|.:...:|.::|
  Fly   139 QTYRTQITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFV 203

Human  1057 RAALDRE---AQELYILKVMAVSGSKAELGQ-QTGTATVRVSILNQNEHSPRLSEDPTFLAVAEN 1117
            ...|||:   .:..:...|.|    :.|.|: ..|.|.::|::.:.|:::|:..:...|..|.||
  Fly   204 LKPLDRDQPNGRPQWRFTVFA----QDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTEN 264

Human  1118 QPPGTSVGRVFATDRD---SGPNGRLTYSLQQ--LSEDSKA--FRIHPQTGEV-TTLQTLDREQQ 1174
            ...|:||..:.|.|.|   ...|.:|.||:::  :.|::.|  |.|.|:||.: |.:..||||:.
  Fly   265 GTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERT 329

Human  1175 SSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTL 1239
            ..|.:.|...|||.  ...|||..:.|.||||..|.|.:.....                     
  Fly   330 PDYSIQVVAMDGGG--LKGTGTASIRVKDLNDMPPQFTKDEWVT--------------------- 371

Human  1240 QAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSAS 1304
               :.|| .|||.:                            .|.|  :||::..|:   ..:.:
  Fly   372 ---EVDE-TNGTYI----------------------------PETP--ILTVTVQDE---DETNT 399

Human  1305 LQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTL 1369
            .|  .:|:|:                                             :|.||..:.:
  Fly   400 FQ--YKVVPN---------------------------------------------SGFGADKFAM 417

Human  1370 VGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVR---------AEGPGGAGARLLR---V 1422
            |...|  ||       |.|.:.:|||:|  .|.::...|         .:||||:....:.   |
  Fly   418 VRNGD--GT-------GSLKIIQPLDYE--DPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWV 471

Human  1423 QVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALR 1487
            .|:::|.|::.|.|.|:.:.:::.|:.:.|..|..|:|:||| .|.:|.|.|:::|.........
  Fly   472 VVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDAD-QGGHSKVAYKIVRSTNRKRQFA 535

Human  1488 LDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRV 1552
            :..| ||:|..|.|||||.....:.:.|.|   :.|..|.|..:..|.|.|.|||||.||...:.
  Fly   536 ISDR-GAVSIQRPLDRETQDRHHIQILAID---DGSPARTATATLTVIVKDVNDNAPTFAQDYKP 596

Human  1553 RLPEDQPPGPAALHVVARDPDLGEAARVSYRL-ASGGDGHFRL---------------------- 1594
            .|||: ..|...|.|.|:|||        .|| .:||...|||                      
  Fly   597 TLPEN-VSGKKILEVAAKDPD--------DRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDN 652

Human  1595 HSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLL- 1658
            .:....:|.:||.|||.:..:.:.:...|:|:|..:.|..|||::.||||.  ..|....|||: 
  Fly   653 ENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDN--KMQPGSKSVLVY 715

Human  1659 -RENNPPGTSLLTLRATDP-DVGANGQVTYGGVSS-ESFSLDPDTGVLTTLRALDREEQEEINLT 1720
             .:.....|.:..:...|| |.....:..|..|.. :.|.||.|||:| |:||..|..:.::...
  Fly   716 NYQGQSQDTPIGRVYVNDPDDWDVPDKKYYWEVQEHQRFKLDTDTGIL-TMRAGTRRGRYQLRFK 779

Human  1721 VYAQDRGS---PPQLTHVTVRVAVEDENDHAPTFGSAHLSLE--------VPEGQDPQTLTMLRA 1774
            ||.::.|.   |..|: ||||....:....|.:...:|::.|        |....:|..|...| 
  Fly   780 VYDREHGQEDIPANLS-VTVRDITAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEPSKLERFR- 842

Human  1775 SDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDG-GQPALSAT 1838
                   |...:....|.|....|.:.|..|.     |.     |...:...||.. .||...|.
  Fly   843 -------NKLAELLYTDRDNVDVFSVQLKEGS-----PY-----PLTDVHFAARSATQQPYFKAV 890

Human  1839 LLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQ--AHDPDAGANGHVTYYLGAGTAGA 1901
            .|..|             |..:..|:.:||.....::.:.  .|:             |.|..| 
  Fly   891 RLNGV-------------VQMHREEIEKDVGLNITMVNINECLHE-------------GKGKCG- 928

Human  1902 FLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLR 1966
                  |....:...|.::   .||.||:.         :..|.|.:.:.               
  Fly   929 ------SNSCTSKVELGKK---PYTVSVNR---------TALVGVRLDIS--------------- 960

Human  1967 LRLPRPGPSFSTPTLALATLRAED---RDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVA 2028
                           |....||.:   :|......:.|.      .|..|::..|...|| .||.
  Fly   961 ---------------AQCVCRARNFTHQDHNCRTHLCYN------GGRCVETRNGPKCVA-CPVG 1003

Human  2029 L-GPRDR--------------------------VLFIVATDLGRPARSATGVIIVGLQGEAERGP 2066
            . |||.:                          :.||        .|.|.|:|:.       .||
  Fly  1004 YNGPRCQQSTRSFRGNGWAWYPPLQLCQESHLSLEFI--------TRVADGLILY-------NGP 1053

Human  2067 RFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEG 2131
            ..|....|..|.:.                     |...:..|..:........|..:.|::.:.
  Fly  1054 IVPPKPEETVISDF---------------------IALELEQGYPRLLIDFGSGTLELRVKTKKT 1097

Human  2132 LDFEVSPRLRLVLQAESGGA---FAFTVLTLTLQDA-----NDNA--PRFLRPHYVAFLPESRPL 2186
            ||..|..||.:....|:...   |..|.|...::|.     :|||  .|...|.:...|..::||
  Fly  1098 LDDGVWHRLDIFWDTENVRMVVDFCRTALVSEMEDGTPPEFDDNACQARGQIPPFAESLNLNQPL 1162

Human  2187 E-GPLLQVEADDL---------DQGSGGQI--------SYSLAASQPARGLFHVDPTTGTITTTA 2233
            : |.|.:...|..         .:|..|.|        .|.||....||..|...|.|..:....
  Fly  1163 QLGGLYRQHFDQTLYNWQYAFSSKGFDGCIRNVIHNSEHYDLAFPALARNSFPACPQTDEVCLKT 1227

Human  2234 ILDREIWAETRLV---LMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEI 2295
            ......|.....|   :.|.....|..:|...          |.||||..::.:......|..|.
  Fly  1228 EHTARCWEHGNCVASLVQAKCHCQPGWMGPGC----------NVPTIPTTFKAQSYVKFALSFEP 1282

Human  2296 AQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGG---RVS------------LTGPLDFEQCDRY 2345
            .:.:                :..|..|.....||   |||            ..|.|.|    ||
  Fly  1283 DRFS----------------TQLQLRFRTREQGGELFRVSDQHHREYAILELRRGHLQF----RY 1327

Human  2346 QLQLLAHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGH 2410
            .|..:.::   |....||.:.  |||.         |..::..:..|||.|    .:.|.|.:..
  Fly  1328 NLNSMRNE---EQLLTLTAIA--VNDG---------QWHVIRISRYGSAAL----MELDGGESRR 1374

Human  2411 I--SYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQ 2473
            .  |:|                 ||       ||..     :.::.::....|..|..|.....:
  Fly  1375 YNESFH-----------------FT-------GHQW-----LTIDKQEGVYAGGKAEYTGIKTFE 1410

Human  2474 DQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLA 2538
            .|:|...|                     .|:....||  .|..:..::....||     :..:|
  Fly  1411 VQSDFQRS---------------------CLDDIRLDG--KHLPLPPAMNGTQWG-----QATMA 1447

Human  2539 EAGESAGPGPRALGCLVLLEPLDFESL-TQYNLTVA-----------AADRGQPPQSSVVPVTVT 2591
            ...|...|..|....::..:|.|...| .:|..|.:           ..||.   :...:|....
  Fly  1448 RNLERNCPSNRPCSNVICPDPFDCVDLWNEYECTCSEGRIMSSDTKGCVDRN---ECLDLPCLNG 1509

Human  2592 VLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESS 2656
            ...:|..|    |..||...||                  |..|.....|..|.     .|..|.
  Fly  1510 ATCINLEP----RLRYRCICPE------------------GYWGENCELVQEGQ-----RLKLSM 1547

Human  2657 GTLR---------LAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDV---NDHGPAFPLN 2709
            |.|.         |..||.....:|.:...:....:|....:....|..:|.   .|...||.:.
  Fly  1548 GALGAIFVCLIIILILALIFVLYSRKRKTTKKKKRSGPEKDVRETVISYEDEGGGEDDMTAFDIT 1612

Human  2710 LLSTSV-AENQPPGTLVTTLHAIDGDAGAFGRLRYSLLE-AGPGPEGREAFALNSSTGELRARV- 2771
            .|...: |:..||......:..|           |.::. ..||.|...|:.:.    |.:.|: 
  Fly  1613 PLQIPISAQGGPPDIAACKMPII-----------YPVMTLLPPGQELNVAYLME----ERKQRID 1662

Human  2772 ------PFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVF-----LAPAFH----FQ 2821
                  |||.....:|.        |:.|.:.::|.|.:|.|:.:..|     ..|.|:    ..
  Fly  1663 KDNNAPPFDDLRNFTFE--------GSGSIAESLSSLASGTDDENQDFNYLQNWGPRFNALAAMY 1719

Human  2822 VPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGAL-----YLRVDSRAPGSGT 2881
            |.:.|:...     |...:.||..|......|:||...|...|.|..     .|.|  .|.|||.
  Fly  1720 VHDKAKASS-----QLPSDGGGGSGDGPGPGASSSSPLGGGGTGGGSGIPGNVLAV--VATGSGA 1777

Human  2882 ATSGGGG 2888
            ...||||
  Fly  1778 GPGGGGG 1784

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DCHS1NP_003728.1 Cadherin_repeat 49..139 CDD:206637
Cadherin_repeat 150..251 CDD:206637
Cadherin_repeat 260..358 CDD:206637
Cadherin_repeat 374..468 CDD:206637
Cadherin_repeat 482..574 CDD:206637
Cadherin_repeat 583..681 CDD:206637
Cadherin_repeat 689..781 CDD:206637
Cadherin_repeat 794..890 CDD:206637 4/9 (44%)
Cadherin_repeat 900..991 CDD:206637 28/97 (29%)
Cadherin_repeat 1004..1101 CDD:206637 27/111 (24%)
Cadherin_repeat 1114..1207 CDD:206637 37/100 (37%)
Cadherin_repeat 1224..1312 CDD:206637 11/87 (13%)
Cadherin_repeat 1336..1432 CDD:206637 23/107 (21%)
Cadherin_repeat 1445..1542 CDD:206637 32/96 (33%)
Cadherin_repeat 1551..1644 CDD:206637 32/115 (28%)
Cadherin_repeat 1653..1747 CDD:206637 29/100 (29%)
Cadherin_repeat 1757..1851 CDD:206637 20/102 (20%)
Cadherin_repeat 1860..1956 CDD:206637 15/97 (15%)
Cadherin_repeat 1983..2056 CDD:206637 20/102 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2065..2094 5/28 (18%)
Cadherin_repeat 2074..2167 CDD:206637 16/100 (16%)
Cadherin_repeat 2175..2273 CDD:206637 22/118 (19%)
Cadherin_repeat 2282..2372 CDD:206637 20/104 (19%)
Cadherin_repeat 2381..2478 CDD:206637 17/98 (17%)
Cadherin_repeat 2486..2598 CDD:206637 19/123 (15%)
Cadherin_repeat 2606..2702 CDD:206637 19/107 (18%)
Cadherin_repeat 2712..2808 CDD:206637 20/104 (19%)
Cadherin_repeat 2818..2923 CDD:206637 23/80 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2986..3040
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3062..3082
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3233..3298
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637 29/97 (30%)
Cadherin_repeat 140..248 CDD:206637 27/111 (24%)
Cadherin_repeat 256..359 CDD:206637 37/104 (36%)
Cadherin_repeat 379..481 CDD:206637 32/192 (17%)
Cadherin_repeat 489..586 CDD:206637 32/101 (32%)
Cadherin_repeat 594..703 CDD:206637 33/117 (28%)
Cadherin_repeat 724..801 CDD:206637 26/78 (33%)
EGF_CA 977..1010 CDD:238011 11/39 (28%)
LamG 1013..1198 CDD:238058 39/220 (18%)
EGF_2 <1233..1259 CDD:285248 5/25 (20%)
Laminin_G_2 1293..1428 CDD:280389 40/208 (19%)
EGF_CA 1497..1535 CDD:238011 12/62 (19%)
Cadherin_C 1583..1719 CDD:279398 31/158 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3B9B2
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100175
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.710

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