Protein Alignment RUNX3 and RunxA

DIOPT Version :9

• Sequence 1: NP_001026850.1
• Gene: RUNX3 / 864
• HGNCID: 10473
• Length: 429
• Species: Homo sapiens
• Sequence 2: NP_001259747.1
• Gene: RunxA / 4379817
• FlyBaseID: FBgn0083981
• Length: 663
• Species: Drosophila melanogaster
• Alignment Length: 445
• Identity: 165/445 - (37%)
• Similarity: 204/445 - (45%)
• Gaps: 109/445 - (24%)

Human    22 STSRRFTPPSPAFPCGGGGGKMGENSGALSAQAAVGPGGRARPEVRSMVDVLADHAGELVRTDSP 86
            |.:.:.|||:||........||  .|..|:.              |::.|.|.:|.|||:||.||
  Fly    57 SNTEQNTPPTPAQLLNEAYTKM--TSDILAE--------------RTLGDFLTEHPGELIRTSSP 105

Human    87 NFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFND 151
            .|:|:|||.|||.|||||||||||:|||:.|||:|||.|||||||.|||||.:||||||||:|||
  Fly   106 LFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFND 170

Human   152 LRFVGRSGRGKSFTLTITVFTNPTQVATYHRAIKVTVDGPREPR-RHRQKLEDQTKPFPDRFGDL 215
            |||||||||||||||||||.|||..:|||::||||||||||||| :....|..|.:.|...||
  Fly   171 LRFVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFG-- 233

Human   216 ERLRMRVTPSTPSPRGSLSTTSHFSSQPQTPIQGTSELNPFSDPRQFDRSFPTLPTLTESRFPDP 280
                              ....|||:.|         |:.|..|          |........:.
  Fly   234 ------------------QRPFHFSTDP---------LSGFRMP----------PIGNCQSASNT 261

Human   281 RMHYPGAMSAAFPYSATPSGTSISSLSVAGMPATSRFHHTYL-----------PPPYPGAPQNQS 334
            ...|..|.||..||.|:      |.||....|.:::|::..|           ...:.||.....
  Fly   262 HWGYGSAASAYSPYLAS------SGLSSCTTPTSAQFNNPALGFTCSSNDQSNNQDFGGATNRDC 320

Human   335 GPF----QANPSPYHL--YYGTSSGSYQFSMVAGSSSGGDRSPTRMLASCTSSAASVAAGNLMNP 393
            .|.    .|:....||  ..|::||......:.|:......|.|...||...||.:..||
  Fly   321 VPMLPDSTASDLDQHLSSLVGSTSGQMTHHSLLGAGGQTSISSTVNGASGGGSAGAGTAG----- 380

Human   394 SLGGQSDGVEADG-----------------------SHSNSPTALSTPGRMDEAV 425
              ||...|..|.|                       |..|.|.:||...:.:..|
  Fly   381 --GGAGSGGGAGGGAGGNSILVPRYHTNASNEYNVHSSQNGPRSLSDSSQAESPV 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RUNX3	NP_001026850.1	Runt	76..197	CDD:307137	97/121 (80%)
		Atrophin-1	<191..325	CDD:331285	31/145 (21%)
		RunxI	330..429	CDD:312115	27/125 (22%)
RunxA	NP_001259747.1	Runt	95..216	CDD:279225	97/120 (81%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2778
eggNOG	1	0.900	-	-		E1_KOG3982
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	212	1.000	Inparanoid score	I3652
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000993
OrthoInspector	1	1.000	-	-		mtm8468
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X738
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.920