Protein Alignment RUNX3 and run

DIOPT Version :9

• Sequence 1: NP_001026850.1
• Gene: RUNX3 / 864
• HGNCID: 10473
• Length: 429
• Species: Homo sapiens
• Sequence 2: NP_001285501.1
• Gene: run / 33059
• FlyBaseID: FBgn0003300
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 497
• Identity: 159/497 - (31%)
• Similarity: 217/497 - (43%)
• Gaps: 125/497 - (25%)

Human    20 DPSTSRRFTPPSPAFPCGGGGGKMGENSGALSAQAAVGPGGRAR-PEVRSMVDVLA-------DH 76
            :|:.|...|....|...|.....:..|:.:.|:.|...|...|: |.  ||.|:.|       ::
  Fly    52 NPAQSLANTSTHSASSTGSSTPDLSTNNTSSSSNATTSPQNSAKMPS--SMTDMFASLHEMLQEY 114

Human    77 AGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAV 141
            .|||.:|.||:.|||.||:|||.||:||.||||:||.||||||:|::..||||||..||||.:..
  Fly   115 HGELAQTGSPSILCSALPNHWRSNKSLPGAFKVIALDDVPDGTLVSIKCGNDENYCGELRNCTTT 179

Human   142 MKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPTQVATYHRAIKVTVDGPREPRRHRQKLEDQTK 206
            ||||||:|||||||||||||||||||||:.|.|.|:|:|.:|||||||||||||    ..:....
  Fly   180 MKNQVAKFNDLRFVGRSGRGKSFTLTITIATYPVQIASYSKAIKVTVDGPREPR----SKQSYGY 240

Human   207 PFPDRF-----------------GDLERLRMRVTPS-----------------TPSPRGSLSTTS 237
            |.|..|                 |..:..|.:....                 :|:|..|::|:|
  Fly   241 PHPGAFNPFMLNPAWLDAAYMTYGYADYFRHQAAAQAAQVHHPALAKSSASSVSPNPNPSVATSS 305

Human   238 HFSSQPQ---------------------TPIQGTSELNPFSDPRQFDRSFPTLPTLTESRFPDPR 281
            ..:.||.                     :| .|.:...|::.|                :||...
  Fly   306 SSAVQPSEYPHPAAAVAAAAGQPAAMMPSP-PGAAPATPYAIP----------------QFPFNH 353

Human   282 MHYPGAMSAAFPYSATPSGTSISSLSVAGMPA-TSRFHHTYLPPPYPGAPQNQSGPFQANPSPYH 345
            :....|..||.|::..|    .:..:.||:.| .:..||...|.....|   .|.|..::|:..|
  Fly   354 VAAAAAAKAATPHAFHP----YNFAAAAGLRARNAALHHQSEPVHVSPA---SSRPSSSSPTQQH 411

Human   346 LYYGTSSGSYQFSMVAGSSSGGDR--------------------SPTRMLASCTSSAASVAAGNL 390
            :....::.....|:...|:|.||.                    :|.||  .|...|.|.
  Fly   412 VLLKLNTSIETSSIHEQSASDGDSDDEQIDVVKSEFDLDKSLDVAPLRM--RCDLKAPSA----- 469

Human   391 MNPSLGGQSDGVEADGSHSNSP---TALSTPGRMDEAVWRPY 429
            |.|.......|..|: |...||   |.:.:.....:.|||||
  Fly   470 MKPLYHESGPGAVAN-SRQPSPETTTKIKSAAVQQKTVWRPY 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RUNX3	NP_001026850.1	Runt	76..197	CDD:307137	86/120 (72%)
		Atrophin-1	<191..325	CDD:331285	34/189 (18%)
		RunxI	330..429	CDD:312115	26/121 (21%)
run	NP_001285501.1	Runt	114..235	CDD:279225	86/124 (69%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142096
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3982
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5099
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000993
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11950
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X738
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.840