Protein Alignment RUNX3 and lz

DIOPT Version :10

• Sequence 1: NP_001026850.1
• Gene: RUNX3 / 864
• HGNCID: 10473
• Length: 429
• Species: Homo sapiens
• Sequence 2: NP_511099.2
• Gene: lz / 31883
• FlyBaseID: FBgn0002576
• Length: 826
• Species: Drosophila melanogaster
• Alignment Length: 514
• Identity: 160/514 - (31%)
• Similarity: 211/514 - (41%)
• Gaps: 167/514 - (32%)

Human    13 YSPTFIRDPSTS-------------RRFTPPSPAFPCGGGGGKMGENSG---------ALSAQAA 55
            :.|..:...|||             :..|..:.|...|.||...|..:.         |:|:.|:
  Fly   151 HPPAMVTSSSTSPTGNGWSSSTGDFKGITAVATATGGGVGGATQGATASTGATAAEVLAVSSSAS 215

Human    56 VG----PGGRARPEVRS---------------------------------MVDVL---------- 73
            ||    .||.:.....|                                 ..|:|
  Fly   216 VGSSSPTGGASNGTAHSGHSGHTGGHSSSTASNNNNNGASNSNSNNNNAVHQDLLWMERLVQKRQ 280

Human    74 ADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNA 138
            .:|.||||||.:|.||||.||:|||.|||||:|||||||.:|.|||.||:.||||||..|||||.
  Fly   281 QEHPGELVRTSNPYFLCSALPAHWRSNKTLPMAFKVVALAEVGDGTYVTIRAGNDENCCAELRNF 345

Human   139 SAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPTQVATYHRAIKVTVDGPREPRR------- 196
            :..|||.||:||||||||||||||||||||||.|:|.|||||.:|||||||||||||.
  Fly   346 TTQMKNDVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPRSKTSPTGG 410

Human   197 -HRQKLEDQTKPFPDRF------GDLERLR-----MRVTPS-----------------------T 226
             |.:.|....:|:.|.|      .:||.||     ..||.:                       |
  Fly   411 PHYRALGLGQRPYIDGFPSTKALHELESLRRSAKVAAVTTAAAAAATAASAANAVAAAAAAVAVT 475

Human   227 PSPRG------------SLSTTSHFSSQPQTPIQGTSELNPFSDPRQFDRSFPTL---------- 269
            |:..|            ........||...:|   .|.:|  ||.:.:..:.|.:
  Fly   476 PTGGGGGVAAGGVAGGAGAGLVQQLSSNYSSP---NSTIN--SDCQVYKPNAPHIQAAEMMGAGE 535

Human   270 ----PTLTESRFPDPRMHYPGAMSA--------AFPYSATPSGTSISSLSVAGMPATSRF----- 317
                .:.:.:.:.....|:|.|..|        |.|....|...:..|:.|.|..||...
  Fly   536 WTNGSSSSAAAYYHSHAHHPHAHHAHAHLQHQMALPPPPPPPAAAPVSVGVGGNGATMGMGMGVG 600

Human   318 ------HHTYLPPPYPGAPQNQSGPFQAN-PS--PYHLYYGTSSGSYQFSMVAGSSSGG 367
                  |:   ...|..|...::|.:.|: |:  |....:|.::..||.:...|.::||
  Fly   601 VGMGMNHY---GGGYDSANSLEAGQYAAHLPAVLPEMHGHGFATDPYQTAGYGGGNTGG 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RUNX3	NP_001026850.1	Runt	69..197	CDD:459963	95/145 (66%)
		PHA03247	<191..325	CDD:223021	40/220 (18%)
		RunxI	330..429	CDD:430037	10/41 (24%)
lz	NP_511099.2	Runt	281..404	CDD:459963	93/122 (76%)