Protein Alignment CBFA2T3 and cbfa2t3

DIOPT Version :10

• Sequence 1: NP_005178.4
• Gene: CBFA2T3 / 863
• HGNCID: 1537
• Length: 653
• Species: Homo sapiens
• Sequence 2: XP_021333653.3
• Gene: cbfa2t3 / 563252
• ZFINID: ZDB-GENE-070209-2
• Length: 701
• Species: Danio rerio
• Alignment Length: 657
• Identity: 440/657 - (66%)
• Similarity: 491/657 - (74%)
• Gaps: 87/657 - (13%)

Human    58 KASAMPDSPAEVKTQPRSTPPSMPPPPPAASQGATRPPSFTPHTHREDGPATLPHGRFHGCLKWS 122
            ||..||||||:||||||||||:|||||||.||...|..||||.|
Zfish    71 KAGTMPDSPADVKTQPRSTPPTMPPPPPAVSQAVNRNASFTPTT--------------------- 114

Human   123 MVCLLMNGSSHSPTAINGAPCTPNGFSNGPATSSTASLSTQHLPPACGARQLSKLKRFLTTLQQF 187
                ::|||||||||:||||.|||||||||||||||||.||.||||||||||.||||||||||||
Zfish   115 ----MLNGSSHSPTALNGAPSTPNGFSNGPATSSTASLPTQQLPPACGARQLCKLKRFLTTLQQF 175

Human   188 GSDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCAR 252
            |:|||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   176 GNDISPEIGERVRSLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCAR 240

Human   253 LAKQTPAQYLAQHEQLLLDASASSPIDSSELLLEVNENGKRRTPDRTKENGSDRDPLHPEHLSKR 317
            :|||||||||||||||||||:|.||:||||::||:||:||||||||||||..|||.||.|||:||
Zfish   241 MAKQTPAQYLAQHEQLLLDANAISPLDSSEIMLELNEHGKRRTPDRTKENAGDRDGLHQEHLAKR 305

Human   318 PCTLNPAQRYSPS-----------------NGPPQPTP--PPHYRLEDIAMAHHFRDAYRHPDPR 363
            |||::|:||:|||                 ||.|.|.|  |.||||||:|:|||:||||||.:.|
Zfish   306 PCTVSPSQRFSPSSGLPAHPPPNGLPTHPPNGLPHPNPPAPQHYRLEDMALAHHYRDAYRHAEHR 370

Human   364 ELRERHRPLVVPGSRQEEVIDHKLTEREWAEEWKHLNNLLNCIMDMVEKTRRSLTVLRRCQEADR 428
            ::|:|||...|.|:||||||||:||:||||||||||:||||||||||||||||||||||||||||
Zfish   371 DVRDRHRQSAVHGARQEEVIDHRLTDREWAEEWKHLDNLLNCIMDMVEKTRRSLTVLRRCQEADR 435

Human   429 EELNHWARRYSDAEDTKKG------PAPAAARPRSSSA----GPEGPQLDVPREFLPRTLTGYVP 483
            ||:|||.|||||.||.|||      |.|......|||:    ..|...|::.|:||.|..:||:|
Zfish   436 EEMNHWIRRYSDVEDMKKGGSSAQRPPPLPPHHNSSSSNTPNSSETQPLEIHRDFLHRPPSGYLP 500

Human   484 EDIWRKA------------------EEAVNEVKRQAMSELQKAVSDAERKAHELITTERAKMERA 530
            |:|||||                  ||||||||||||||||||||||||||||:|:.||:|||||
Zfish   501 EEIWRKAGTTSIPLSPALKQLQNKQEEAVNEVKRQAMSELQKAVSDAERKAHEMISAERSKMERA 565

Human   531 LAEAKRQASEDALTVINQQEDSSESCWNCGRKASETCSGCNAARYCGSFCQHRDWEKHHHVCGQS 595
            |||||||||||||||||||||||||||||||||||||||||.||||||||||:|||||||||||.
Zfish   566 LAEAKRQASEDALTVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHVCGQG 630

Human   596 LQ-------GPTAVVADPVPGPPEAAHSLGPSLPVGAA-------SPSEAGSAGPSRPGSPSPPG 646
            |.       |..:..:.....||..:.|..|. |:..|       ||.||.|:..||..:|:.|.
Zfish   631 LPSSSGVPLGTPSTTSTSSSAPPTHSESTTPG-PLSLAGQTSSGGSPKEASSSSVSRSTTPATPA 694

Human   647 PLDTVPR 653
            .:|:..|
Zfish   695 LMDSSSR 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CBFA2T3	NP_005178.4	Interaction with ZBTB33. /evidence=ECO:0000269|PubMed:23251453	145..242		91/96 (95%)
		TAFH	173..262	CDD:462195	84/88 (95%)
		Interaction with HIF1A. /evidence=ECO:0000269|PubMed:25974097	176..268		88/91 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	284..342		41/76 (54%)
		NHR2	379..445	CDD:430219	59/65 (91%)
		Nervy homology region 2 (NHR2), essential for down-regulation of PFKFB3, PFKFB4 and PDK1 expression. /evidence=ECO:0000269|PubMed:23840896	394..412		16/17 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	434..472		18/47 (38%)
		vATP-synt_E	482..>553	CDD:419987	64/88 (73%)
		Nervy homology region 3 (NHR3), essential for down-regulation of PFKFB3, PFKFB4 and PDK1 expression. /evidence=ECO:0000269|PubMed:23840896	485..533		42/65 (65%)
		Mediates interaction with PRKAR2A. /evidence=ECO:0000269|PubMed:11823486	485..506		19/38 (50%)
		zf-MYND	556..592	CDD:460312	33/35 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	603..653		16/56 (29%)
		Mediates localization to the nucleus. /evidence=ECO:0000250	1..435		292/395 (74%)
		Mediates interaction with PDE7A (in isoform 2)	1..430		288/390 (74%)
		Required for nucleolar targeting (in isoform 1)	1..127		33/68 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..109		33/50 (66%)
cbfa2t3	XP_021333653.3	None