DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CBFA2T3 and nvy

DIOPT Version :9

Sequence 1:	NP_005178.4	Gene:	CBFA2T3 / 863	HGNCID:	1537	Length:	653	Species:	Homo sapiens
Sequence 2:	NP_001261166.1	Gene:	nvy / 37886	FlyBaseID:	FBgn0005636	Length:	757	Species:	Drosophila melanogaster

Alignment Length:	730	Identity:	213/730 - (29%)
Similarity:	309/730 - (42%)	Gaps:	186/730 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    14 ASGSTCGSMSQTHPVLESGLLASAGCSAPRGPRKGGPAPVDRKAKASAMPDSPAEVKTQPRS--- 75
            ||.|:.||.|.......:...::|..:|....|....:....|:..|:.....:...:..||
  Fly    49 ASSSSAGSASSAAAAATNNTTSAAATAAAISRRLKASSSGGDKSSTSSSSSKDSSHTSSSRSERD 113

Human    76 ----------------TPPSMPPPPPAASQGATRPPSFTP---HTHREDGPATLPHGRFHGCLKW 121
                            |||.  .||.::...|.|.| .:|   |.|.:...:..|
  Fly   114 RERERERERERDRLCRTPPD--SPPDSSRSLAPRSP-HSPLQLHQHPQRNASVSP---------- 165

Human   122 SMVCLLMNGSSHSPTAI--NGAPCTPNGFSNGPATSSTASLSTQHLPPACG----ARQLSKLKRF 180
                 ::||||.....:  :|...||.     |.:...|||:......|..    ||.:||:::|
  Fly   166 -----VVNGSSSGGGGVGSSGTSPTPT-----PGSQHAASLAAAAAAAAAAHVEQARLVSKMRKF 220

Human   181 LTTLQQFGSDI-SPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQ 244
            |..|.||..:: .||:.||||.|||.|.:.::::|||...||||.|.||||:|:|.||.::.|:|
  Fly   221 LGALVQFSQELGQPEVCERVRALVLSLCSGSISVEEFRLALQEAINLPLRPYVVPLLKNSIALVQ 285

Human   245 RELLHCARLAKQTPAQYLAQHEQLLLDAS----ASSPIDSSELLLEV-NENG-----KRRTPDRT 299
            ||:|..||...|:..||:..:||.:::.:    ||:......:.||. ..||     |||:.|..
  Fly   286 REILALARATNQSALQYVTNNEQAVMEFAPHGVASAEFGDIFIQLEAPTSNGSSAVFKRRSSDSM 350

Human   300 KENGSDRDPLHPEHLSKRPCTLNPAQRYSPSNGPPQPTPPPHYRLEDIAMAHHF----------- 353
            .|:|....             |.....|..|.|...| |||..|| .:..||..
  Fly   351 MEHGGHNG-------------LQEWNEYMASGGAGYP-PPPSKRL-TLHPAHSVVAYGEYGVSSA 400

Human   354 -----RDAYRHPDPRELR-----ERH------------RPLV----VPGSRQEEVIDHKLTEREW 392
                 ..|:...|.|:||     .||            .|..    .||:..|
  Fly   401 EGLPSAAAFMQRDERDLRMSEAQARHAAPPQRAGNPQPNPNAAAPGAPGAGGE------------ 453

Human   393 AEEWKHLNNLLNCIMDMVEKTRRSLTVLRRCQEADREELNHWARRYSDAEDTKKGPAPAAARPRS 457
             ||||:::.:||||..||:||:|::|:|:                       ::|..|  ..|.|
  Fly   454 -EEWKNIHTMLNCISAMVDKTKRAITILQ-----------------------QRGIEP--QHPNS 492

Human   458 SSAGPEGPQLDVPREFLPRTLTGYVPEDIWRKAEEAVNEVKRQAMSELQKAVSDAERKAHELITT 522
            ..........::.|:      |.....:..|.||:||.:|||||:.|:|:||..||.:|.|::|.
  Fly   493 GQEVTPAAMAELRRQ------TEEKVAEFKRNAEDAVTQVKRQAVIEIQRAVVAAETRAAEIMTQ 551

Human   523 ERAKMERALAEAKRQASED------ALTVINQQEDSS--ESCWNCGRKASETCSGCNAARYCGSF 579
            ||.:||:...|..|.:|.:      :.::.:.|..|:  :.||||||||:|||||||.||||.:.
  Fly   552 ERLRMEKFFMEMSRHSSGERDLDNKSPSMASAQNGSNLQQQCWNCGRKATETCSGCNMARYCSAS 616

Human   580 CQHRDWEKHHHVCGQ-----------------SLQGPTAVVADPVPGPPEAAH-SLGPSLPVGAA 626
            ||:|||:.||.|||.                 ||:...|..:.|.|.  .||| ....:....||
  Fly   617 CQYRDWDSHHQVCGNTRASELSAKHLHSASNLSLRNAMATRSPPTPN--SAAHLQAAAAAAAAAA 679

Human   627 SPSEAGSAGPSRPGS 641
            ...||.||....||:
  Fly   680 GAREAVSAPVGGPGA 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CBFA2T3	NP_005178.4	Mediates localization to the nucleus. /evidence=ECO:0000250	1..435		134/496 (27%)
		Mediates interaction with PDE7A (in isoform 2)	1..430		134/491 (27%)
		Required for nucleolar targeting (in isoform 1)	1..127		25/134 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..109		24/116 (21%)
		Interaction with ZBTB33. /evidence=ECO:0000269\|PubMed:23251453	145..242		41/101 (41%)
		TAFH	173..259	CDD:284862	41/86 (48%)
		Interaction with HIF1A. /evidence=ECO:0000269\|PubMed:25974097	176..268		43/92 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..342		18/63 (29%)
		NHR2	379..445	CDD:285941	16/65 (25%)
		Nervy homology region 2 (NHR2), essential for down-regulation of PFKFB3, PFKFB4 and PDK1 expression. /evidence=ECO:0000269\|PubMed:23840896	394..412		10/17 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	434..472		4/37 (11%)
		vATP-synt_E	482..>553	CDD:304907	27/76 (36%)
		Nervy homology region 3 (NHR3), essential for down-regulation of PFKFB3, PFKFB4 and PDK1 expression. /evidence=ECO:0000269\|PubMed:23840896	485..533		23/47 (49%)
		Mediates interaction with PRKAR2A. /evidence=ECO:0000269\|PubMed:11823486	485..506		11/20 (55%)
		zf-MYND	556..592	CDD:280009	26/35 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..653		13/40 (33%)
nvy	NP_001261166.1	TAFH	213..304	CDD:197785	43/90 (48%)
		NHR2	<454..>482	CDD:285941	15/50 (30%)
		zf-MYND	593..629	CDD:280009	26/35 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156479
Domainoid	1	1.000	89	1.000	Domainoid score	I7847
eggNOG	1	0.900	-	-		E1_28KWJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74543
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3425
Isobase	1	0.950	-	0	Normalized mean entropy	S6828
OMA	1	1.010	-	-		QHG50012
OrthoDB	1	1.010	-	-		D198762at33208
OrthoFinder	1	1.000	-	-		FOG0001881
OrthoInspector	1	1.000	-	-		otm42239
orthoMCL	1	0.900	-	-		OOG6_103448
Panther	1	1.100	-	-	LDO	PTHR10379
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1413
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.720