Protein Alignment CBFA2T3 and Cbfa2t3

DIOPT Version :10

• Sequence 1: NP_005178.4
• Gene: CBFA2T3 / 863
• HGNCID: 1537
• Length: 653
• Species: Homo sapiens
• Sequence 2: NP_001101923.1
• Gene: Cbfa2t3 / 361431
• RGDID: 1310547
• Length: 619
• Species: Rattus norvegicus
• Alignment Length: 636
• Identity: 548/636 - (86%)
• Similarity: 573/636 - (90%)
• Gaps: 21/636 - (3%)

Human    22 MSQTHPVLESGLLASAGCSAPRGPRKGGPAPVDRKAKASAMPDSPAEVKTQPRSTPPSMPPPPPA 86
            |||....||||.|    ...|||...|.||  .||.||:|||||||||||||||||||||||||.
  Rat     1 MSQASTTLESGAL----LPGPRGLHNGSPA--HRKEKAAAMPDSPAEVKTQPRSTPPSMPPPPPT 59

Human    87 ASQGATRPPSFTPHTHREDGPAT-LPHGRFHGCLKWSMVCLLMNGSSHSPTAINGAPCTPNGFSN 150
            :|||||||||||||||.|||||| |||||||||||||||||||||||||||||:|||.|||||||
  Rat    60 SSQGATRPPSFTPHTHGEDGPATSLPHGRFHGCLKWSMVCLLMNGSSHSPTAIHGAPSTPNGFSN 124

Human   151 GPATSSTASLSTQHLPPACGARQLSKLKRFLTTLQQFGSDISPEIGERVRTLVLGLVNSTLTIEE 215
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   125 GPATSSTASLSTQHLPPACGARQLSKLKRFLTTLQQFGSDISPEIGERVRTLVLGLVNSTLTIEE 189

Human   216 FHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQTPAQYLAQHEQLLLDASASSPIDS 280
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||:||
  Rat   190 FHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQTPAQYLAQHEQLLLDASATSPVDS 254

Human   281 SELLLEVNENGKRRTPDRTKENGSDRDPLHPEHLSKRPCTLNPAQRYSPSNGPPQPT--PPPHYR 343
            |||||||||||||:|||||||||||||||||:|||||.|||:||||.|||||.|.||  ||||||
  Rat   255 SELLLEVNENGKRKTPDRTKENGSDRDPLHPDHLSKRSCTLSPAQRCSPSNGLPHPTPPPPPHYR 319

Human   344 LEDIAMAHHFRDAYRHPDPRELRERHRPLVVPGSRQEEVIDHKLTEREWAEEWKHLNNLLNCIMD 408
            |||:||||||||:||||||||||||||||.:|||||||||||:||||||||||||||:|||||||
  Rat   320 LEDMAMAHHFRDSYRHPDPRELRERHRPLAIPGSRQEEVIDHRLTEREWAEEWKHLNSLLNCIMD 384

Human   409 MVEKTRRSLTVLRRCQEADREELNHWARRYSDAEDTKKGPAPAAARPRSSSAGPEGPQLDVPREF 473
            |.||||||||||||||||||||||||.|.|||:|:.||||.|.:||..:|.:|.||.||||.|:|
  Rat   385 MAEKTRRSLTVLRRCQEADREELNHWIRCYSDSEEGKKGPTPISARSLNSCSGSEGSQLDVHRDF 449

Human   474 LPRTLTGYVPEDIWRKAEEAVNEVKRQAMSELQKAVSDAERKAHELITTERAKMERALAEAKRQA 538
            .||||:||:||:|||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   450 TPRTLSGYMPEEIWRKAEEAVNEVKRQAMSELQKAVSDAERKAHELITTERAKMERALAEAKRQA 514

Human   539 SEDALTVINQQEDSSESCWNCGRKASETCSGCNAARYCGSFCQHRDWEKHHHVCGQSLQGPTAVV 603
            ||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||.|.|
  Rat   515 SEDALTVINQQEDSSESCWNCGRKASETCSGCNAARYCGSFCQHKDWEKHHHVCGQSLQGPAAAV 579

Human   604 ADPVPGPPEAAHSLGPSLPVGAASPSEAGSAGPSRPGSPSPPGPLDT-VPR 653
            |||:||.|:|           .||||||||||||||.||.||.|||| |||
  Rat   580 ADPLPGQPDA-----------TASPSEAGSAGPSRPCSPGPPVPLDTAVPR 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CBFA2T3	NP_005178.4	Interaction with ZBTB33. /evidence=ECO:0000269|PubMed:23251453	145..242		96/96 (100%)
		TAFH	173..262	CDD:462195	88/88 (100%)
		Interaction with HIF1A. /evidence=ECO:0000269|PubMed:25974097	176..268		91/91 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	284..342		50/59 (85%)
		NHR2	379..445	CDD:430219	58/65 (89%)
		Nervy homology region 2 (NHR2), essential for down-regulation of PFKFB3, PFKFB4 and PDK1 expression. /evidence=ECO:0000269|PubMed:23840896	394..412		15/17 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	434..472		21/37 (57%)
		vATP-synt_E	482..>553	CDD:419987	68/70 (97%)
		Nervy homology region 3 (NHR3), essential for down-regulation of PFKFB3, PFKFB4 and PDK1 expression. /evidence=ECO:0000269|PubMed:23840896	485..533		46/47 (98%)
		Mediates interaction with PRKAR2A. /evidence=ECO:0000269|PubMed:11823486	485..506		19/20 (95%)
		zf-MYND	556..592	CDD:460312	34/35 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	603..653		31/50 (62%)
		Mediates localization to the nucleus. /evidence=ECO:0000250	1..435		370/415 (89%)
		Mediates interaction with PDE7A (in isoform 2)	1..430		365/410 (89%)
		Required for nucleolar targeting (in isoform 1)	1..127		80/105 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..109		62/86 (72%)
Cbfa2t3	NP_001101923.1	TAFH	147..236	CDD:462195	88/88 (100%)
		NHR2	355..421	CDD:430219	58/65 (89%)
		NtpE	460..>514	CDD:441000	52/53 (98%)
		zf-MYND	532..568	CDD:460312	34/35 (97%)