Protein Alignment CBFA2T3 and Cbfa2t3

DIOPT Version :10

• Sequence 1: NP_005178.4
• Gene: CBFA2T3 / 863
• HGNCID: 1537
• Length: 653
• Species: Homo sapiens
• Sequence 2: XP_030099127.1
• Gene: Cbfa2t3 / 12398
• MGIID: 1338013
• Length: 693
• Species: Mus musculus
• Alignment Length: 667
• Identity: 551/667 - (82%)
• Similarity: 577/667 - (86%)
• Gaps: 35/667 - (5%)

Human     2 PASRLRDRAASSASGSTCGSMSQTHPVLESGLLASAGCSA-PRGPRKGGPAPVD----------R 55
            ||.|.| |......|...|        :..|..|..|..| |...|..|....|          |
Mouse    47 PAGRTR-RWPGYPEGLAKG--------VRGGAAAEGGAPASPSRSRHRGSGSSDAVGLRLLRAHR 102

Human    56 KAKASAMPDSPAEVKTQPRSTPPSMPPPPPAASQGATRPPSFTPHTHREDGPAT-LPHGRFHGCL 119
            |.||:|||||||||||||||||||||||||.:|||||||||||||||.|||||| ||||||||||
Mouse   103 KEKAAAMPDSPAEVKTQPRSTPPSMPPPPPTSSQGATRPPSFTPHTHGEDGPATSLPHGRFHGCL 167

Human   120 KWSMVCLLMNGSSHSPTAINGAPCTPNGFSNGPATSSTASLSTQHLPPACGARQLSKLKRFLTTL 184
            |||||||||||||||||||:|||.|||||||||||||||||||||||||||||||||||||||||
Mouse   168 KWSMVCLLMNGSSHSPTAIHGAPSTPNGFSNGPATSSTASLSTQHLPPACGARQLSKLKRFLTTL 232

Human   185 QQFGSDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLH 249
            |||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||
Mouse   233 QQFGSDISPEIGERVRTLVLGLVNSTLTIEEFHAKLQEATNFPLRPFVIPFLKANLPLLQRELLH 297

Human   250 CARLAKQTPAQYLAQHEQLLLDASASSPIDSSELLLEVNENGKRRTPDRTKENGSDRDPLHPEHL 314
            |||||||||||||||||||||||||:||:|||||||||||||||||||||||||||||||||:||
Mouse   298 CARLAKQTPAQYLAQHEQLLLDASATSPVDSSELLLEVNENGKRRTPDRTKENGSDRDPLHPDHL 362

Human   315 SKRPCTLNPAQRYSPSNGPPQPT--PPPHYRLEDIAMAHHFRDAYRHPDPRELRERHRPLVVPGS 377
            |||.|||:||||.|||||.|.||  |||||||||:||||||||:||||||||||||||||.:|||
Mouse   363 SKRSCTLSPAQRCSPSNGLPHPTPPPPPHYRLEDMAMAHHFRDSYRHPDPRELRERHRPLAIPGS 427

Human   378 RQEEVIDHKLTEREWAEEWKHLNNLLNCIMDMVEKTRRSLTVLRRCQEADREELNHWARRYSDAE 442
            ||||||||:||||||||||||||:|||||||||||||||||||||||||||||||||.|.|||:|
Mouse   428 RQEEVIDHRLTEREWAEEWKHLNSLLNCIMDMVEKTRRSLTVLRRCQEADREELNHWIRCYSDSE 492

Human   443 DTKKGPAPAAARPRSSSAGPEGPQLDVPREFLPRTLTGYVPEDIWRKAEEAVNEVKRQAMSELQK 507
            :.||||.|.:||..:|.:||||.||||.|:|.||||:||:||:||||||||||||||||||||||
Mouse   493 EGKKGPTPISARSLNSCSGPEGSQLDVHRDFTPRTLSGYMPEEIWRKAEEAVNEVKRQAMSELQK 557

Human   508 AVSDAERKAHELITTERAKMERALAEAKRQASEDALTVINQQEDSSESCWNCGRKASETCSGCNA 572
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   558 AVSDAERKAHELITTERAKMERALAEAKRQASEDALTVINQQEDSSESCWNCGRKASETCSGCNA 622

Human   573 ARYCGSFCQHRDWEKHHHVCGQSLQGPTAVVADPVPGPPEAAHSLGPSLPVGAASPSEAGSAGPS 637
            ||||||||||:||||||||||||||||.|.||||:||.|:|           .||||||||||||
Mouse   623 ARYCGSFCQHKDWEKHHHVCGQSLQGPAAAVADPLPGQPDA-----------TASPSEAGSAGPS 676

Human   638 RPGSPSPPGPLD-TVPR 653
            ||.||.|||||| .|||
Mouse   677 RPCSPGPPGPLDAAVPR 693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CBFA2T3	NP_005178.4	Interaction with ZBTB33. /evidence=ECO:0000269|PubMed:23251453	145..242		95/96 (99%)
		TAFH	173..262	CDD:462195	87/88 (99%)
		Interaction with HIF1A. /evidence=ECO:0000269|PubMed:25974097	176..268		90/91 (99%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	284..342		51/59 (86%)
		NHR2	379..445	CDD:430219	59/65 (91%)
		Nervy homology region 2 (NHR2), essential for down-regulation of PFKFB3, PFKFB4 and PDK1 expression. /evidence=ECO:0000269|PubMed:23840896	394..412		16/17 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	434..472		22/37 (59%)
		vATP-synt_E	482..>553	CDD:419987	68/70 (97%)
		Nervy homology region 3 (NHR3), essential for down-regulation of PFKFB3, PFKFB4 and PDK1 expression. /evidence=ECO:0000269|PubMed:23840896	485..533		46/47 (98%)
		Mediates interaction with PRKAR2A. /evidence=ECO:0000269|PubMed:11823486	485..506		19/20 (95%)
		zf-MYND	556..592	CDD:460312	34/35 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	603..653		31/50 (62%)
		Mediates localization to the nucleus. /evidence=ECO:0000250	1..435		372/446 (83%)
		Mediates interaction with PDE7A (in isoform 2)	1..430		367/441 (83%)
		Required for nucleolar targeting (in isoform 1)	1..127		81/136 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..109		63/117 (54%)
Cbfa2t3	XP_030099127.1	TAFH	221..310	CDD:462195	87/88 (99%)
		NHR2	429..495	CDD:430219	59/65 (91%)
		NtpE	534..>588	CDD:441000	52/53 (98%)
		zf-MYND	606..642	CDD:460312	34/35 (97%)