DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TP63 and p53

DIOPT Version :9

Sequence 1:	NP_003713.3	Gene:	TP63 / 8626	HGNCID:	15979	Length:	680	Species:	Homo sapiens
Sequence 2:	NP_996267.1	Gene:	p53 / 2768677	FlyBaseID:	FBgn0039044	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	425	Identity:	87/425 - (20%)
Similarity:	154/425 - (36%)	Gaps:	106/425 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    32 KESYYRSTMSQSTQ-TNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATNKIEISMD- 94
            |.:.:..|.:|:|. .:...|..:|:...:||:            |.|..:|..|.:.:.:|.:
  Fly     5 KSASFSLTFNQNTSIVSRSNSRTIFEAFKEFLD------------FWDIGNEVSAESAVRVSSNG 57

Human    95 CIRMQDS---------DLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYA 150
            ...:..|         .|:.|:.|.|......|.|  |..|.....:..|:| ..|.:.|.:.:.
  Fly    58 AFNLPQSFGNESNEYAHLATPVDPAYGGNNTNNMM--QFTNNLEILANNNSD-GNNKINACNKFV 119

Human   151 QPSSTFDALSPSPAIPSNTDYP------------GPHSF------------------------DV 179
            ....| |:...|..:....|.|            .|.:|                        |:
  Fly   120 CHKGT-DSEDDSTEVDIKEDIPKTVEVSGSELTTEPMAFLQGLNSGNLMQFSQQSVLREMMLQDI 183

Human   180 SFQQSSTAK-------------------SATWTYSTELKKLYCQIAKTCPIQIKVMTPPP-QGAV 224
            ..|.::..|                   .:.|.||..|.|||.::.|...:.::..:..| |...
  Fly   184 QIQANTLPKLENHNIGGYCFSMVLDEPPKSLWMYSIPLNKLYIRMNKAFNVDVQFKSKMPIQPLN 248

Human   225 IRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVE-------GNSHAQYVEDPITG 282
            :|....:  :..|:..|.||.||................|:|.|       ||:..:.:.:
  Fly   249 LRVFLCF--SNDVSAPVVRCQNHLSVEPLTANNAKMRESLLRSENPNSVYCGNAQGKGISE---- 307

Human   283 RQSVLVPY----EPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEAR 343
            |.||:||.    ...:.|....|:.:.|:|.:||:|   |:...::..||...|.::|:.....:
  Fly   308 RFSVVVPLNMSRSVTRSGLTRQTLAFKFVCQNSCIG---RKETSLVFCLEKACGDIVGQHVIHVK 369

Human   344 ICACPGRDRKADE---DSIRKQQVSDSTKNGDGTK 375
            ||.||.|||..||   :|.:::.|.::.:..:.:|
  Fly   370 ICTCPKRDRIQDERQLNSKKRKSVPEAAEEDEPSK 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TP63	NP_003713.3	Transcription activation	1..107		15/85 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..171		9/47 (19%)
		P53	163..358	CDD:307150	55/264 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..393		7/28 (25%)
		Interaction with HIPK2. /evidence=ECO:0000269\|PubMed:11925430	352..388		6/27 (22%)
		P53_tetramer	392..431	CDD:311579
		Oligomerization	394..443
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	435..472
		Forkhead_N	457..>534	CDD:312062
		SAM_tumor-p63	543..607	CDD:188971
		Transactivation inhibition	610..680
p53	NP_996267.1	P53	203..383	CDD:176262	47/188 (25%)
p53	NP_996267.1	P53_C	429..495	CDD:288471
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147024
Domainoid	1	1.000	65	1.000	Domainoid score	I10037
eggNOG	1	0.900	-	-		E1_2C1DX
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002925
OrthoInspector	1	1.000	-	-		otm41285
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11447
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5172
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.830