Protein Alignment CDK13 and Cdk12

DIOPT Version :9

• Sequence 1: XP_016868239.1
• Gene: CDK13 / 8621
• HGNCID: 1733
• Length: 1542
• Species: Homo sapiens
• Sequence 2: NP_001262167.1
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Alignment Length: 1145
• Identity: 434/1145 - (37%)
• Similarity: 573/1145 - (50%)
• Gaps: 262/1145 - (22%)

Human    90 KRLARGKRRAGGRQKRR-----------------------RGPRAGQEAEKRRVFSLPQPQQDGG 131
            |...:.|:::..|:|:|                       ..|.|..::.:|.|.:.|.......
  Fly   144 KHKHKSKKKSKKRKKKRAKSYSSIDSMSDNDINALLDRRYTPPTAPSKSNERTVSAAPSSFTPHN 208

Human   132 GGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGG------TGGSGGS-------PAS 183
            ...||.....|.|...:.:|.     ..|.:|..||.:|.|.      |.....|       |:|
  Fly   209 LKESSSPATPPPVRRPNTNSN-----YYGESSLETANSALGSNLQVTVTNKQSISNRLRSPPPSS 268

Human   184 -SSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSR-SRHSHSGEERAEVA 246
             |||...|...|.|.|.....||||..           |...||....|| ||:.:|..:....|
  Fly   269 RSSGNGPRFGNSPRTPPPSHYSSSGGG-----------GVGSGSVVRDSRSSRYVNSPHKEDVSA 322

Human   247 KSGSSSSSGGRRKSASATSSSSSSRK--------DR-----DSKAHRSRTKS------------S 286
            ...||...|.:.:.:.|.|||..:||        ||     .:..|:.|..|            |
  Fly   323 HHRSSHDHGYQGRYSGAGSSSHDTRKVKRLSPELDRYNHQPSTPPHKRRKFSDGREVGLGNFEHS 387

Human   287 KEPPSAYKEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSS-- 349
            :.....|:.    |..|:     |.||.|.||            :.|..|||:|||  ||.||
  Fly   388 RHHSGKYER----YSRDR-----YSRRSSRSP------------SVQHSRSRQSPS--GGLSSGS 429

Human   350 -----------PYSRRLPRSPSPYSRRRSPSYSRHSSYERGGD-VSPSPYSSSSWRRSRSPYSPV 402
                       .|...:..:||..:|    :..|.|.....|| .|.||.:||.:..| ||.|||
  Fly   430 NAFRHGGSHKHKYGTTVSSTPSHTTR----TSKRASGTGTSGDRYSRSPRTSSRYMES-SPPSPV 489

Human   403 LRRSGKSRS------RSPYSSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARA 461
                |.|.|      |||...:.:|..||.|...|.|..||.|.|    :|..:.:|   |..|.
  Fly   490 ----GASGSHHYHHRRSPRMRQRTRGDSRRRSPSSASSESSASRS----RSPTSRDL---KHKRE 543

Human   462 AEAARAAEAAKAAEATKAAEAAAKAAK------ASNTSTPTKG----NTETSASASQTNHVKDVK 516
            ....:.:|.:..||..|......||.|      ..|:::.:.|    |..:|:....|.:..|.:
  Fly   544 EYIKKISETSLFAELVKDRHKRQKALKEIIERQEENSNSNSNGALTINDNSSSVDGNTPNAADGR 608

Human   517 KIKIEHAP---SPSSGGTLKN--DKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEE 576
            .     ||   :|::..|..|  ....:||.|.:    ||:.:......:|:    |..|:..:.
  Fly   609 S-----APGSGTPAAASTTSNGLQALGSKPDLDL----NNIPMPNKQNDSVV----SNPASNADV 660

Human   577 SVSLKEKTKP-LTPSIGAKEKEQHVALVTSTLPPLPLPPML-------------PEDKEADSLRG 627
            ..|:.:..:| |.|...|.:..    :...:|..|||||.:             .:.||:|....
  Fly   661 PDSVAQLKQPLLVPPFSASKNN----IKPKSLTSLPLPPGMNVLDLAGARSPSPGQKKESDEKNV 721

Human   628 NISVKAVKKEVEKKLRCLLADLPLPPELPGGDDLS------KSPE--EKKTATQLH--------S 676
            ..|..|.|.         :.:||:||.:||.::||      .|||  :......:|        :
  Fly   722 TSSGSANKS---------VLNLPMPPVIPGSEELSGDDDVIDSPEDFDAPAVGTVHGHGGGPGTT 777

Human   677 KRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNE 741
            ::||.|...|  :::....|||:||||.|::|..||||||||||||||..|.:|||||||||::|
  Fly   778 RQRPVILNRR--DSRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHE 840

Human   742 KEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGL 806
            ||||||||:|||||||||.|::|:|:.||||||:||::|:||||:|||||||||||||||||||:
  Fly   841 KEGFPITAVREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGM 905

Human   807 VHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESAWLM 871
            |.|||.:..|.|:||::||:||||||||||||||||||:||||::|||||||||||:::
  Fly   906 VDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNAD------ 964

Human   872 LIWEKVIFIWRILLMQMSAGSFGDSSRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGE 936
                                   |..||||||||||||||||||||||||.|:||||||||||||
  Fly   965 -----------------------DRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGE 1006

Human   937 LFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAA 1001
            ||.|:|:||||.|:||||.||:|||||.|||||:|||||.|:|:|.||.:||:|||:|.|:||.|
  Fly  1007 LFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHRRRLREDFEFMPAPA 1071

Human  1002 LDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTDD 1066
            |||.|.||.|||.||.|||.||:..:||.:.|.:||.|.||.|||||||||||||||
  Fly  1072 LDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQLPTWQDCHELWSKKRRRQ-------- 1128

Human  1067 VSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNV 1106
                          :.:.:.:.|..|:.|::.:..|::.|
  Fly  1129 --------------MREQQESLPPTVIASTKYQQHGATMV 1154

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK13	XP_016868239.1	None
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	227/330 (69%)
		S_TKc	804..1098	CDD:214567	221/322 (69%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155034
Domainoid	1	1.000	465	1.000	Domainoid score	I471
eggNOG	1	0.900	-	-		E1_KOG0600
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	590	1.000	Inparanoid score	I992
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	1	1.000	-	-		FOG0000444
OrthoInspector	1	1.000	-	-		otm40905
orthoMCL	1	0.900	-	-		OOG6_101677
Panther	1	1.100	-	-	O	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R186
SonicParanoid	1	1.000	-	-		X546
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790