Protein Alignment CDK13 and Pitslre

DIOPT Version :9

• Sequence 1: XP_016868239.1
• Gene: CDK13 / 8621
• HGNCID: 1733
• Length: 1542
• Species: Homo sapiens
• Sequence 2: NP_649251.2
• Gene: Pitslre / 40292
• FlyBaseID: FBgn0016696
• Length: 952
• Species: Drosophila melanogaster
• Alignment Length: 1130
• Identity: 272/1130 - (24%)
• Similarity: 428/1130 - (37%)
• Gaps: 334/1130 - (29%)

Human   170 AAGGTGGSGGSPAS----SSGTQRRGEGSE-----RRPRRDRRSSSG--RSKERHREHRRRDGQR 223
            ::|...|...||..    |.|.:...||..     :.|:..|.|.||  |.|::|...|||..:|
  Fly     4 SSGSEDGQLRSPNDVHYHSRGEEDEHEGDADALYIQPPQASRESGSGPRREKKKHSRERRRHKER 68

Human   224 ---GGSEAS---------KSRSRHSHSGEERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDS 276
               ||:..:         :||..|.|..:                |.:|::|.::.        :
  Fly    69 DDVGGAALALERDHRYDYRSREEHYHHHQ----------------RERSSNAAAAY--------A 109

Human   277 KAHRSRTKSSKEPPSAYKEP----PK-----------------AYREDKTEPKAYR--------- 311
            |.|........:||...::|    |.                 |.||..:.|..|.
  Fly   110 KHHLGHAYHYPQPPQQQQQPLPPAPSYAAHHYHHHQHLSGARAAPREYHSYPSGYHSGSRHGDYP 174

Human   312 ----RRRSLSPLGGRDDSPVSHRASQSLRSR-----------------------KSPSPAGGGSS 349
                .|||......:|    :....|.||||                       :|....||...
  Fly   175 MEEPTRRSSKYAESKD----AESLEQDLRSRLLKKRHNYVKDYETEENYEHRVERSDRREGGRKE 235

Human   350 PYSRRLPRSPSPYSRR-------RSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSG 407
              ..|..||....:|.       .||....|..::...       ..|.||..    ..|:||..
  Fly   236 --RERTVRSTHKQNRHDRVIELLDSPEQEHHHQHQHKS-------HRSKWREE----VEVIRRKV 287

Human   408 KS-------RSRSPYSSRHSRSR---------SRHRLSRSRSRHS-SISPSTLTLKSSLAAELN- 454
            ..       |.:...:.|.||.|         :|..|.|.|:.|| ::||:|:.  :|:.|.||
  Fly   288 PEDLELLARREKLLAAERESRQRKQTAREELEARRELLRERNEHSDALSPTTVA--ASVTAGLNI 350

Human   455 ---------------KNKKARA--AEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTET 502
                           |.||.|.  .|..|..:..::.|:....|...:.::.|    .|:..:|.
  Fly   351 HVKRKSKPDNYEKEIKLKKRREDDIEVIRDDDDEESEESDSNEEVPEQDSEGS----ATESGSED 411

Human   503 SASASQTNHVKDVKKIK--IEHAPSPSS----GGTLKNDKAKTKPPLQVTKVENNLIVDKATKKA 561
            |.::.:.:.:|...:::  .|..|.|.|    |...|:.|.:.:         :..:..|::.::
  Fly   412 SYASKKKSKIKSKSQLEDDDEDLPLPDSPLSVGELYKSPKQRQR---------SRSVSSKSSSQS 467

Human   562 VIVGK---ESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEAD 623
            ....:   .|:|.::.|:.|..::.....:||...:.:|:            .:....||:|..:
  Fly   468 SRSSRSRSRSRSQSSLEDEVDRQDVGADASPSSSTRSEER------------GMTQEQPEEKPEE 520

Human   624 SLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYG 688
            .|      |..:|.:|:::.|....:|||...||..
  Fly   521 KL------KEKQKSLEEQIPCDDKGIPLPNYYPGVQ----------------------------- 550

Human   689 ETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREI 753
                     |.|.|::|..:..|.|||||.||:|:||.|.|:||||:::::.||||||||::|||
  Fly   551 ---------GCRSVEEFQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKEGFPITSLREI 606

Human   754 KILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLE---SGLVHFNENHIK 815
            ..|.:..|.:|:.::|||...      ..||  .::|.:|::|||..|:|   :....|....:|
  Fly   607 NTLLKGQHPNIVTVREIVVGS------NMDK--IFIVMDYVEHDLKSLMETMKNRKQSFFPGEVK 663

Human   816 SFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESAWLMLIWEKVIFI 880
            ...:||:..:.:.|....||||:|.||:||:::|.:|:.||||||.|
  Fly   664 CLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREY------------------ 710

Human   881 WRILLMQMSAGSFGDSSRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQ 945
                         |...:.||:.|:|||||.|||||....|:..|||||.|||..|.....|:|.
  Fly   711 -------------GSPIKKYTSLVVTLWYRAPELLLCSPVYSTPIDVWSVGCIFAEFLQMLPLFP 762

Human   946 ANQELAQLELISRICGSPCPAVWPDVIKLPYFNTM---------KPKKQYRRKLREEFVFIPAAA 1001
            ...|:.:|..|.:..|:|...:||...:||....|         .|..|.|:..:|:   .....
  Fly   763 GKSEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQFTEYPVSQLRKHFQEK---TSEMG 824

Human  1002 LDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTDD 1066
            |.|...:|..||.:|.:|:.||:..|.::: |..:.|...|.|....||.::|
  Fly   825 LSLLQGLLTYDPKQRLSADAALKHGFFKEL-PLPIDPSMFPTWPAKSELGARK------------ 876

Human  1067 VSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAPVKTGPGQHLNHSELAILLNLLQS 1131
                             ::.::|:.....||.|..|...  |:..|||..|  |...|..|....
  Fly   877 -----------------AQASSPKPPSGGSQFKQLGRDE--PIIVGPGNKL--SSGIITGNKKSH 920

Human  1132 KTSVNMADFVQVLNIKVNSETQQQL 1156
            ....:.|....|||..:   ||:||
  Fly   921 GAGGSSASTGFVLNAGI---TQRQL 942

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK13	XP_016868239.1	None
Pitslre	NP_649251.2	STKc_CDC2L1	552..851	CDD:173741	118/340 (35%)
		PLN00009	555..854	CDD:177649	118/340 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920