Protein Alignment CDK13 and Cdk9

DIOPT Version :10

• Sequence 1: XP_016868239.1
• Gene: CDK13 / 8621
• HGNCID: 1733
• Length: 1542
• Species: Homo sapiens
• Sequence 2: NP_477226.2
• Gene: Cdk9 / 37586
• FlyBaseID: FBgn0019949
• Length: 404
• Species: Drosophila melanogaster
• Alignment Length: 384
• Identity: 152/384 - (39%)
• Similarity: 221/384 - (57%)
• Gaps: 39/384 - (10%)

Human   703 DKFDIIGIIGEGTYGQVYKARD-KDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIIN 766
            :|::.:..||:||:|:|:|||: |...:.||:|||.:|||||||||||:|||:||:.|.|::::|
  Fly    48 NKYEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNEKEGFPITALREIRILQLLKHENVVN 112

Human   767 MKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKK 831
            :.||...|..|.:  ..:..|||||::.:|||.|||.:..|.|:...||..|:||:.||.|.|..
  Fly   113 LIEICRTKATATN--GYRSTFYLVFDFCEHDLAGLLSNMNVKFSLGEIKKVMQQLLNGLYYIHSN 175

Human   832 NFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESAWLMLIWEKVIFIWRILLMQMSAGSFGDS 896
            ..||||:|.:|:|:...|.:|||||||||.:|..::                           :|
  Fly   176 KILHRDMKAANVLITKHGILKLADFGLARAFSIPKN---------------------------ES 213

Human   897 SRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICG 961
            ...|||:|:||||||||||||:..|.|.:|:|..|||:.|::|:.||.|.|.|..||..||::||
  Fly   214 KNRYTNRVVTLWYRPPELLLGDRNYGPPVDMWGAGCIMAEMWTRSPIMQGNTEQQQLTFISQLCG 278

Human   962 SPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEF--VFIPAAALDLFDYMLALDPSKRCTAEQALQ 1024
            |..|.|||.|.:|..:.:::..|..:|:::|..  ........||.|.:|.|||.||..|:.||.
  Fly   279 SFTPDVWPGVEELELYKSIELPKNQKRRVKERLRPYVKDQTGCDLLDKLLTLDPKKRIDADTALN 343

Human  1025 CEFL-RDVEP---SKMPPPDLPLWQDCHELWSKKRRRQKQMGMTDDVSTIKAPRKDLSL 1079
            .:|. .|..|   |||....|   |...|..::.||..:.......::|:....:|.|:
  Fly   344 HDFFWTDPMPSDLSKMLSQHL---QSMFEYLAQPRRSNQMRNYHQQLTTMNQKPQDNSM 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK13	XP_016868239.1	STKc_CDK12	697..1028	CDD:270847	138/327 (42%)
Cdk9	NP_477226.2	STKc_CDK9	37..347	CDD:270848	138/327 (42%)