DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CDK13 and Cdk9

DIOPT Version :9

Sequence 1:	XP_016868239.1	Gene:	CDK13 / 8621	HGNCID:	1733	Length:	1542	Species:	Homo sapiens
Sequence 2:	NP_477226.2	Gene:	Cdk9 / 37586	FlyBaseID:	FBgn0019949	Length:	404	Species:	Drosophila melanogaster

Alignment Length:	384	Identity:	152/384 - (39%)
Similarity:	221/384 - (57%)	Gaps:	39/384 - (10%)

- Green bases have known domain annotations that are detailed below.

Human   703 DKFDIIGIIGEGTYGQVYKARD-KDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIIN 766
            :|::.:..||:||:|:|:|||: |...:.||:|||.:|||||||||||:|||:||:.|.|::::|
  Fly    48 NKYEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNEKEGFPITALREIRILQLLKHENVVN 112

Human   767 MKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKK 831
            :.||...|..|.:  ..:..|||||::.:|||.|||.:..|.|:...||..|:||:.||.|.|..
  Fly   113 LIEICRTKATATN--GYRSTFYLVFDFCEHDLAGLLSNMNVKFSLGEIKKVMQQLLNGLYYIHSN 175

Human   832 NFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESAWLMLIWEKVIFIWRILLMQMSAGSFGDS 896
            ..||||:|.:|:|:...|.:|||||||||.:|..::                           :|
  Fly   176 KILHRDMKAANVLITKHGILKLADFGLARAFSIPKN---------------------------ES 213

Human   897 SRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICG 961
            ...|||:|:||||||||||||:..|.|.:|:|..|||:.|::|:.||.|.|.|..||..||::||
  Fly   214 KNRYTNRVVTLWYRPPELLLGDRNYGPPVDMWGAGCIMAEMWTRSPIMQGNTEQQQLTFISQLCG 278

Human   962 SPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEF--VFIPAAALDLFDYMLALDPSKRCTAEQALQ 1024
            |..|.|||.|.:|..:.:::..|..:|:::|..  ........||.|.:|.|||.||..|:.||.
  Fly   279 SFTPDVWPGVEELELYKSIELPKNQKRRVKERLRPYVKDQTGCDLLDKLLTLDPKKRIDADTALN 343

Human  1025 CEFL-RDVEP---SKMPPPDLPLWQDCHELWSKKRRRQKQMGMTDDVSTIKAPRKDLSL 1079
            .:|. .|..|   |||....|   |...|..::.||..:.......::|:....:|.|:
  Fly   344 HDFFWTDPMPSDLSKMLSQHL---QSMFEYLAQPRRSNQMRNYHQQLTTMNQKPQDNSM 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDK13	XP_016868239.1	None
Cdk9	NP_477226.2	STKc_CDK9	37..347	CDD:270848	138/327 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	1	1.000	-	-		FOG0000444
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R186
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950