Protein Alignment RUNX1T1 and runx1t1

DIOPT Version :10

• Sequence 1: NP_001185608.1
• Gene: RUNX1T1 / 862
• HGNCID: 1535
• Length: 663
• Species: Homo sapiens
• Sequence 2: XP_068071293.1
• Gene: runx1t1 / 767809
• ZFINID: ZDB-GENE-060929-164
• Length: 635
• Species: Danio rerio
• Alignment Length: 582
• Identity: 527/582 - (90%)
• Similarity: 552/582 - (94%)
• Gaps: 7/582 - (1%)

Human    89 DRTEKHSTMPDSPVDVKTQSRLTPPTMPPPPTTQGAPRTSSFTPTTLTNGTSHSPTALNGAPSPP 153
            |||||.|||||||.|||||||||||||||||||||||||||||||.|||||||||||||||||||
Zfish    54 DRTEKRSTMPDSPADVKTQSRLTPPTMPPPPTTQGAPRTSSFTPTALTNGTSHSPTALNGAPSPP 118

Human   154 NGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNST 218
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   119 NGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNST 183

Human   219 LTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTT 283
            |||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||.|||
Zfish   184 LTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELVHCARLAKQNPAQYLAQHEQLLLDTSTT 248

Human   284 SPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGL 348
            |||||||||:|||||||||||||||||||:|||||.|||:|||||||||||:||:||||||||||
Zfish   249 SPVDSSELLMDVNENGKRRTPDRTKENGFEREPLHPEHPNKRPCTISPGQRFSPSNGLSYQPNGL 313

Human   349 PHPTPPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHG--TRQEEMIDHRLTDREWAE 411
            |||||||||||||||||||||||||||||:||:||||.||:|:||  |||||:||||||||||||
Zfish   314 PHPTPPPPQHYRLDDMAIAHHYRDSYRHPNHRELRDRPRPLGMHGSSTRQEEVIDHRLTDREWAE 378

Human   412 EWKHLDH---LLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGGSSSSHSR 473
            |||||||   ||||||||||||||||||||||||.||||||||||||||||||||...:|:|.||
Zfish   379 EWKHLDHVRKLLNCIMDMVEKTRRSLTVLRRCQETDREELNYWIRRYSDAEDLKKTSSTSTSQSR 443

Human   474 QQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHDMI 538
            ||||.:.:..||:.|||.||||.||||||||||||||||||||||||:||||||||||||||:||
Zfish   444 QQSPASQEGNALEVHRELLHRPVSGYVPEEIWKKAEEAVNEVKRQAMSELQKAVSEAERKAHEMI 508

Human   539 TTERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDW 603
            :|||||||||||||:||||||||:|||||||||||||||||||||||||||||||||||||||||
Zfish   509 STERAKMERTVAEARRQAAEDALSVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDW 573

Human   604 EKHHHICGQTLQAQQQGDTPA-VSSSVTPNSGAGSPMDTP-PAATPRSTTPGTPSTIETTPR 663
            |||||:|||||||||||:||| ||||.||:||||||.||| .||||||.|||||||:|.|||
Zfish   574 EKHHHVCGQTLQAQQQGETPATVSSSATPSSGAGSPADTPSAAATPRSATPGTPSTVENTPR 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RUNX1T1	NP_001185608.1	TAFH	181..270	CDD:462195	87/88 (99%)
		NHR2	396..462	CDD:430219	63/68 (93%)
		NtpE	502..>556	CDD:441000	49/53 (92%)
		zf-MYND	574..610	CDD:460312	35/35 (100%)
runx1t1	XP_068071293.1	TAFH	146..235	CDD:462195	87/88 (99%)
		NHR2	363..432	CDD:430219	63/68 (93%)
		vATP-synt_E	470..>526	CDD:419987	51/55 (93%)
		zf-MYND	544..580	CDD:460312	35/35 (100%)