Protein Alignment RUNX1T1 and nvy

DIOPT Version :10

• Sequence 1: NP_001185608.1
• Gene: RUNX1T1 / 862
• HGNCID: 1535
• Length: 663
• Species: Homo sapiens
• Sequence 2: NP_001261166.1
• Gene: nvy / 37886
• FlyBaseID: FBgn0005636
• Length: 757
• Species: Drosophila melanogaster
• Alignment Length: 705
• Identity: 197/705 - (27%)
• Similarity: 298/705 - (42%)
• Gaps: 171/705 - (24%)

Human    22 AAVWVPPRPR----PLSRAPLPEAGGENLHLKISRVRKRNLPFVVWGEEEASTPGLDAISHHLCY 82
            |||.|||...    ..|.|..............:....|.|.....|.:::||....:.......
  Fly    42 AAVQVPPASSSSAGSASSAAAAATNNTTSAAATAAAISRRLKASSSGGDKSSTSSSSSKDSSHTS 106

Human    83 PDRTHRDRTEKHS----------TMPDSPVDVKTQSRLTPPTMPPPPTT--QGAPRTSSFTPTTL 135
            ..|:.|||..:..          |.||||.|   .||...|..|..|..  |...|.:|.:|  :
  Fly   107 SSRSERDRERERERERERDRLCRTPPDSPPD---SSRSLAPRSPHSPLQLHQHPQRNASVSP--V 166

Human   136 TNGTSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACG----ARQLSKLKRFLTTLQQFG 196
            .||:|.....:..:.:.|   :..|.|..::|||......|..    ||.:||:::||..|.||.
  Fly   167 VNGSSSGGGGVGSSGTSP---TPTPGSQHAASLAAAAAAAAAAHVEQARLVSKMRKFLGALVQFS 228

Human   197 NDI-SPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCAR 260
            .:: .||:.||||.|||.|.:.::::|||...||||.|.||||:|:|.||.::.|:|||:|..||
  Fly   229 QELGQPEVCERVRALVLSLCSGSISVEEFRLALQEAINLPLRPYVVPLLKNSIALVQREILALAR 293

Human   261 LAKQNPAQYLAQHEQLLLDAST--TSPVDSSELLLDV---NENG-----KRRTPDRTKENGFDRE 315
            ...|:..||:..:||.:::.:.  .:..:..::.:.:   ..||     |||:.|...|
  Fly   294 ATNQSALQYVTNNEQAVMEFAPHGVASAEFGDIFIQLEAPTSNGSSAVFKRRSSDSMME------ 352

Human   316 PLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPPQHYRLDDMAIAHHYRDSYRHPSHR 380
              |..|..     :.....|..:.|..|         ||||.. ||.            .||:|.
  Fly   353 --HGGHNG-----LQEWNEYMASGGAGY---------PPPPSK-RLT------------LHPAHS 388

Human   381 DLRDRNRPMGLHGTRQEEMI------------DHRLTDRE------------------------- 408
            .:     ..|.:|....|.:            |.|:::.:
  Fly   389 VV-----AYGEYGVSSAEGLPSAAAFMQRDERDLRMSEAQARHAAPPQRAGNPQPNPNAAAPGAP 448

Human   409 ---WAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGGSSSS 470
               ..||||::..:||||..||:||:|::|:|::                         .|....
  Fly   449 GAGGEEEWKNIHTMLNCISAMVDKTKRAITILQQ-------------------------RGIEPQ 488

Human   471 HSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAH 535
            |......|.|..:| :..|:...:.|      |..:.||:||.:|||||:.|:|:||..||.:|.
  Fly   489 HPNSGQEVTPAAMA-ELRRQTEEKVA------EFKRNAEDAVTQVKRQAVIEIQRAVVAAETRAA 546

Human   536 DMITTERAKMERTVAEAKRQAAED--------ALAVINQQEDSSESCWNCGRKASETCSGCNTAR 592
            :::|.||.:||:...|..|.::.:        ::|......:..:.||||||||:|||||||.||
  Fly   547 EIMTQERLRMEKFFMEMSRHSSGERDLDNKSPSMASAQNGSNLQQQCWNCGRKATETCSGCNMAR 611

Human   593 YCGSFCQHKDWEKHHHICGQTLQAQQQG------------DTPAVSSSVTPNSGA 635
            ||.:.||::||:.||.:||.|..::...            :..|..|..||||.|
  Fly   612 YCSASCQYRDWDSHHQVCGNTRASELSAKHLHSASNLSLRNAMATRSPPTPNSAA 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RUNX1T1	NP_001185608.1	TAFH	181..270	CDD:462195	42/89 (47%)
		NHR2	396..462	CDD:430219	18/105 (17%)
		NtpE	502..>556	CDD:441000	24/53 (45%)
		zf-MYND	574..610	CDD:460312	25/35 (71%)
nvy	NP_001261166.1	TAFH	213..304	CDD:197785	43/90 (48%)
		NHR2	<454..>482	CDD:430219	15/27 (56%)
		zf-MYND	593..629	CDD:460312	25/35 (71%)