Protein Alignment RUNX1T1 and Runx1t1

DIOPT Version :10

• Sequence 1: NP_001185608.1
• Gene: RUNX1T1 / 862
• HGNCID: 1535
• Length: 663
• Species: Homo sapiens
• Sequence 2: NP_001423845.1
• Gene: Runx1t1 / 362489
• RGDID: 1305490
• Length: 686
• Species: Rattus norvegicus
• Alignment Length: 665
• Identity: 597/665 - (89%)
• Similarity: 606/665 - (91%)
• Gaps: 31/665 - (4%)

Human     5 DKAFTSDKLQCVFNEYKAAVWVPPRPRPLSRAPLPEAGGENLHLKISRVRKRNLPFVVWGEEEAS 69
            ||:..|:.:.|.                  |..|..|.| ||||||:.....:|||||.|||||:
  Rat    47 DKSQGSEDVTCY------------------RELLLAARG-NLHLKITEGEGEDLPFVVLGEEEAA 92

Human    70 ------TPGLDAISHHLCYPDRTHRDRTEKHSTMPDSPVDVKTQSRLTPPTMPPPPTTQGAPRTS 128
                  :|...||.      ..|..|||||||||||||||||||||||||.||||||||||||||
  Rat    93 ALASLLSPNTSAIQ------TGTRGDRTEKHSTMPDSPVDVKTQSRLTPPAMPPPPTTQGAPRTS 151

Human   129 SFTPTTLTNGTSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQ 193
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   152 SFTPTTLTNGTSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQ 216

Human   194 QFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHC 258
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   217 QFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHC 281

Human   259 ARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPS 323
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   282 ARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPS 346

Human   324 KRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRP 388
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   347 KRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRP 411

Human   389 MGLHGTRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIR 453
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   412 MGLHGTRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIR 476

Human   454 RYSDAEDLKKGGGSSSSHSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQ 518
            ||||||||||||..|||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   477 RYSDAEDLKKGGSGSSSHSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQ 541

Human   519 AMTELQKAVSEAERKAHDMITTERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASE 583
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   542 AMTELQKAVSEAERKAHDMITTERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASE 606

Human   584 TCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAQQQGDTPAVSSSVTPNSGAGSPMDTPPAATPR 648
            |||||||||||||||||||||||||||||||||.|||:||||||||||:||||||||||||||||
  Rat   607 TCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAPQQGETPAVSSSVTPSSGAGSPMDTPPAATPR 671

Human   649 STTPGTPSTIETTPR 663
            |||||||||||||||
  Rat   672 STTPGTPSTIETTPR 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RUNX1T1	NP_001185608.1	TAFH	181..270	CDD:462195	88/88 (100%)
		NHR2	396..462	CDD:430219	65/65 (100%)
		NtpE	502..>556	CDD:441000	53/53 (100%)
		zf-MYND	574..610	CDD:460312	35/35 (100%)
Runx1t1	NP_001423845.1	None