Protein Alignment RUNX1 and runx1

DIOPT Version :10

• Sequence 1: NP_001745.2
• Gene: RUNX1 / 861
• HGNCID: 10471
• Length: 480
• Species: Homo sapiens
• Sequence 2: XP_073804988.1
• Gene: runx1 / 58126
• ZFINID: ZDB-GENE-000605-1
• Length: 514
• Species: Danio rerio
• Alignment Length: 501
• Identity: 353/501 - (70%)
• Similarity: 387/501 - (77%)
• Gaps: 61/501 - (12%)

Human     1 MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGAPDA-G 64
            |||:||||||.||..||.||             .:..||||||||.||.|||||.|||||.:: |
Zfish    54 MASNSIFESFQSYQSCFSRE-------------PAPGRRFTPPSTTLSSGKMSEGLPLGAQESTG 105

Human    65 AALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTL 129
            |||.||||..||||||||:||||||||||||||||||||||||||||||||||||||||:|||||
Zfish   106 AALVGKLRMADRSMVEVLSDHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDIPDGTL 170

Human   130 VTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIK 194
            |||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||.||||
Zfish   171 VTVMAGNDENYSAELRNATAAIKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYQRAIK 235

Human   195 ITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAF 259
            |||||||||||||||.|:..|||:|:||      |||||:|||.|||| .|.||.|.:|| :..|
Zfish   236 ITVDGPREPRRHRQKPDEAVKPGALAFS------EQLRRSAMRCSPHH-GPAPNTRPTLN-TPPF 292

Human   260 NPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTA 324
            .....||:.|:||:|.||.|||:|||.|||.|::|:|||.|||||.|    |.|.         .
Zfish   293 GSPAHSQIPDSRQMQTSPSWSYEQSYPYLGPISTPAVHPTTPISPNR----TALH---------C 344

Human   325 PDLTAFSDP-----RQFPALPSI-----SDPRMHYP-GAFTYSPTPVTSGIGIGMSAMGS-ATRY 377
            |:||||:||     |.||:|||:     ||||:.|| |||||:||||||.||||||||.| |.||
Zfish   345 PELTAFTDPRVGLERSFPSLPSLPDGRFSDPRVPYPTGAFTYTPTPVTSAIGIGMSAMSSPAGRY 409

Human   378 HTYLPPPYP-GSSQAQGGPFQASSPSYHLYYGASAGSYQFSMV------GGERSPPRILPPCTNA 435
            ||||||.|| ||||||.|.|||||..|||||.::||||||||:      .||||||||| |||||
Zfish   410 HTYLPPAYPAGSSQAQAGAFQASSSPYHLYYSSAAGSYQFSMMPSGGAAAGERSPPRIL-PCTNA 473

Human   436 STGSALLNPSLPNQSD-VVEAEGSHSNSPTNMAPSARLEEAVWRPY 480
            |||||||:|||||||: |||||||||:|||:|:     .|||||||
Zfish   474 STGSALLHPSLPNQSEGVVEAEGSHSSSPTSMS-----VEAVWRPY 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RUNX1	NP_001745.2	Runt	78..206	CDD:459963	123/127 (97%)
		RunxI	389..480	CDD:430037	69/97 (71%)
runx1	XP_073804988.1	None