Protein Alignment RUNX1 and Runx1

DIOPT Version :10

• Sequence 1: NP_001745.2
• Gene: RUNX1 / 861
• HGNCID: 10471
• Length: 480
• Species: Homo sapiens
• Sequence 2: XP_017453542.1
• Gene: Runx1 / 50662
• RGDID: 2283
• Length: 464
• Species: Rattus norvegicus
• Alignment Length: 480
• Identity: 445/480 - (92%)
• Similarity: 450/480 - (93%)
• Gaps: 16/480 - (3%)

Human     1 MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGAPDAGA 65
            |||||||||||||||||:|             ||||||||||||||||||||||||||||||.||
  Rat     1 MASDSIFESFPSYPQCFVR-------------DASTSRRFTPPSTALSPGKMSEALPLGAPDGGA 52

Human    66 ALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLV 130
            |||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    53 ALASKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLV 117

Human   131 TVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKI 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   118 TVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKI 182

Human   196 TVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFN 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   183 TVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFN 247

Human   261 PQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAP 325
            |||||||||.|||||||||||||||||||||.| |||||||||||||||||:|||||||||||||
  Rat   248 PQPQSQMQDARQIQPSPPWSYDQSYQYLGSITS-SVHPATPISPGRASGMTSLSAELSSRLSTAP 311

Human   326 DLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQ 390
            |||||.||||||.||||||||||||||||||| |||||||||||||.|.:|||||||||||||||
  Rat   312 DLTAFGDPRQFPTLPSISDPRMHYPGAFTYSP-PVTSGIGIGMSAMSSTSRYHTYLPPPYPGSSQ 375

Human   391 AQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPNQSDVVEA 455
            ||.||||..|||||||||.|||||||||||||||||||||||||||||:||||||||:||||||.
  Rat   376 AQAGPFQTGSPSYHLYYGTSAGSYQFSMVGGERSPPRILPPCTNASTGAALLNPSLPSQSDVVET 440

Human   456 EGSHSNSPTNMAPSARLEEAVWRPY 480
            ||||||||||| |.|||||||||||
  Rat   441 EGSHSNSPTNM-PPARLEEAVWRPY 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RUNX1	NP_001745.2	Runt	78..206	CDD:459963	127/127 (100%)
		RunxI	389..480	CDD:430037	81/90 (90%)
Runx1	XP_017453542.1	Runt	65..193	CDD:459963	127/127 (100%)
		RunxI	374..464	CDD:430037	81/90 (90%)