DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RUNX1 and RunxA

DIOPT Version :9

Sequence 1:	NP_001745.2	Gene:	RUNX1 / 861	HGNCID:	10471	Length:	480	Species:	Homo sapiens
Sequence 2:	NP_001259747.1	Gene:	RunxA / 4379817	FlyBaseID:	FBgn0083981	Length:	663	Species:	Drosophila melanogaster

Alignment Length:	479	Identity:	173/479 - (36%)
Similarity:	223/479 - (46%)	Gaps:	118/479 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    24 GMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGE 88
            |.|.:...::::|.:. |||:.|   ..::||......|..|         :|::.:.|.:||||
  Fly    47 GNNNNSSGNNSNTEQN-TPPTPA---QLLNEAYTKMTSDILA---------ERTLGDFLTEHPGE 98

Human    89 LVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKN 153
            |:||.||.|:|:|||.|||.|||||:|||||:|||:.|||:|||.|||||||.|||||.||.|||
  Fly    99 LIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKN 163

Human   154 QVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR-RHRQKLDDQTKPG 217
            |||:||||||||||||||||||||||.||||.:|||::|||:||||||||| :....|..|.:..
  Fly   164 QVAKFNDLRFVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTMLSLLGQQQQF 228

Human   218 SLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYD 282
            ..:|.:|               |.|.:..|        .:.|...|....|......    |.|.
  Fly   229 HFAFGQR---------------PFHFSTDP--------LSGFRMPPIGNCQSASNTH----WGYG 266

Human   283 QSYQ----YLGSIASPSVHPATPISP---GRASGMTTLSAELSSRL----------------STA 324
            .:..    ||.|....|.  .||.|.   ..|.|.|..|.:.|:..                |||
  Fly   267 SAASAYSPYLASSGLSSC--TTPTSAQFNNPALGFTCSSNDQSNNQDFGGATNRDCVPMLPDSTA 329

Human   325 PDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSS 389
            .||    |......:.|.|....|:........|.::|.:. |.|..|||            |:.
  Fly   330 SDL----DQHLSSLVGSTSGQMTHHSLLGAGGQTSISSTVN-GASGGGSA------------GAG 377

Human   390 QAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPP--CTNASTGSALLNPSLPNQSDV 452
            .|.||.            |:..|:      ||......||.|  .||||           |:.:|
  Fly   378 TAGGGA------------GSGGGA------GGGAGGNSILVPRYHTNAS-----------NEYNV 413

Human   453 VEAEGSHSNSPTNMAPSARLEEAV 476
                .|..|.|.:::.|::.|..|
  Fly   414 ----HSSQNGPRSLSDSSQAESPV 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RUNX1	NP_001745.2	Runt	81..207	CDD:395684	98/126 (78%)
RUNX1	NP_001745.2	RunxI	389..480	CDD:400691	22/90 (24%)
RunxA	NP_001259747.1	Runt	95..216	CDD:279225	97/120 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2778
eggNOG	1	0.900	-	-		E1_KOG3982
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000993
OrthoInspector	1	1.000	-	-		mtm8468
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X738
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.870