Protein Alignment RUNX1 and run

DIOPT Version :9

• Sequence 1: NP_001745.2
• Gene: RUNX1 / 861
• HGNCID: 10471
• Length: 480
• Species: Homo sapiens
• Sequence 2: NP_001285501.1
• Gene: run / 33059
• FlyBaseID: FBgn0003300
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 527
• Identity: 167/527 - (31%)
• Similarity: 231/527 - (43%)
• Gaps: 134/527 - (25%)

Human    23 LGMNPSRDV-----HDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVL 82
            :.:||::.:     |.||::...||..:..:....|.|..  :|...|.:...:.....|:.|:|
  Fly    49 IAINPAQSLANTSTHSASSTGSSTPDLSTNNTSSSSNATT--SPQNSAKMPSSMTDMFASLHEML 111

Human    83 ADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNA 147
            .::.|||.:|.||:.|||.||.|||.||:||.||||:||.||||||||::..||||||..||||.
  Fly   112 QEYHGELAQTGSPSILCSALPNHWRSNKSLPGAFKVIALDDVPDGTLVSIKCGNDENYCGELRNC 176

Human   148 TAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDD 212
            |..||||||:|||||||||||||||||||||:.|.|.|:|:|.:|||:|||||||||..:..  .
  Fly   177 TTTMKNQVAKFNDLRFVGRSGRGKSFTLTITIATYPVQIASYSKAIKVTVDGPREPRSKQSY--G 239

Human   213 QTKPGSLS-FSERLSELEQLRRT------------AMRVSPHHPA----------PTPNPRASLN 254
            ...||:.: |....:.|:....|            |.....||||          |.|||..:.:
  Fly   240 YPHPGAFNPFMLNPAWLDAAYMTYGYADYFRHQAAAQAAQVHHPALAKSSASSVSPNPNPSVATS 304

Human   255 HSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSS 319
            .|:|              :|||         :|        .|||..::  .|:|..  :|.:.|
  Fly   305 SSSA--------------VQPS---------EY--------PHPAAAVA--AAAGQP--AAMMPS 334

Human   320 RLSTAPDLTAFSDPRQFP-------ALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRY 377
            ....|| .|.::.| |||       |....:.|...:|..|         ....|:.|..:|..:
  Fly   335 PPGAAP-ATPYAIP-QFPFNHVAAAAAAKAATPHAFHPYNF---------AAAAGLRARNAALHH 388

Human   378 HTYLPPPYPGSSQAQGGPFQASSPSYHLY--------------YGASAG---SYQFSMVGGE--- 422
            .:......|.||:    |..:|....|:.              ..||.|   ..|..:|..|
  Fly   389 QSEPVHVSPASSR----PSSSSPTQQHVLLKLNTSIETSSIHEQSASDGDSDDEQIDVVKSEFDL 449

Human   423 --------------RSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNSPTNMAPSARLE 473
                          ...|..:.|..:.|...|:.|...|:           ..:.|.:..:|..:
  Fly   450 DKSLDVAPLRMRCDLKAPSAMKPLYHESGPGAVANSRQPS-----------PETTTKIKSAAVQQ 503

Human   474 EAVWRPY 480
            :.|||||
  Fly   504 KTVWRPY 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RUNX1	NP_001745.2	Runt	81..207	CDD:395684	88/125 (70%)
		RunxI	389..480	CDD:400691	21/124 (17%)
run	NP_001285501.1	Runt	114..235	CDD:279225	87/120 (73%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3982
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	203	1.000	Inparanoid score	I3751
Isobase	1	0.950	-	0	Normalized mean entropy	S5099
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000993
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11950
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3284
SonicParanoid	1	1.000	-	-		X738
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.990