Protein Alignment RUNX1 and lz

DIOPT Version :10

• Sequence 1: NP_001745.2
• Gene: RUNX1 / 861
• HGNCID: 10471
• Length: 480
• Species: Homo sapiens
• Sequence 2: NP_511099.2
• Gene: lz / 31883
• FlyBaseID: FBgn0002576
• Length: 826
• Species: Drosophila melanogaster
• Alignment Length: 563
• Identity: 181/563 - (32%)
• Similarity: 227/563 - (40%)
• Gaps: 184/563 - (32%)

Human    84 DHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNAT 148
            :||||||||.:|.||||.||.|||.|||||:|||||||.:|.|||.||:.||||||..|||||.|
  Fly   282 EHPGELVRTSNPYFLCSALPAHWRSNKTLPMAFKVVALAEVGDGTYVTIRAGNDENCCAELRNFT 346

Human   149 AAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRR-------- 205
            ..|||.||:||||||||||||||||||||||.|:|||||||.:|||:|||||||||.
  Fly   347 TQMKNDVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPRSKTSPTGGP 411

Human   206 HRQKLDDQTKPGSLSF--SERLSELEQLRR-------TAMRVSPHHPAPTPNPRASLNHSTAFNP 261
            |.:.|....:|....|  ::.|.|||.|||       |....:....|...|..|:...:.|..|
  Fly   412 HYRALGLGQRPYIDGFPSTKALHELESLRRSAKVAAVTTAAAAAATAASAANAVAAAAAAVAVTP 476

Human   262 -----------------------------QPQSQMQDTRQI-QPSPP------------WSYDQS 284
                                         .|.|.:....|: :|:.|            |:...|
  Fly   477 TGGGGGVAAGGVAGGAGAGLVQQLSSNYSSPNSTINSDCQVYKPNAPHIQAAEMMGAGEWTNGSS 541

Human   285 YQYLGSIASPSVHP-----------------------ATPISPGRASGMTTLSAELS-------S 319
            ........|.:.||                       |.|:|.|......|:...:.       :
  Fly   542 SSAAAYYHSHAHHPHAHHAHAHLQHQMALPPPPPPPAAAPVSVGVGGNGATMGMGMGVGVGMGMN 606

Human   320 RLSTAPDLTAFSDPRQFPA-LPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPP 383
            ......|.....:..|:.| ||::. |.||..| |...|.. |:|.|.|.:..|||::
  Fly   607 HYGGGYDSANSLEAGQYAAHLPAVL-PEMHGHG-FATDPYQ-TAGYGGGNTGGGSASK------- 661

Human   384 PYPGSSQAQGGPF-QASSPSYHLY-YGASAGSYQFSMVGGERSPPRILPP--------------- 431
                |....||.: ||.|..|..| ||:...:.|:   |.:.:||...||
  Fly   662 ----SELDYGGSYNQAWSNGYQNYQYGSCLATAQY---GPQAAPPPQPPPPPPVVLCPQLYSTVN 719

Human   432 --------------------CTNAS-------TGSALLNPSL----------------------- 446
                                .|:|.       |||:..:..:
  Fly   720 QNQIHLHLHSSEKLEQYLGTATSADHLTIGSLTGSSRSSIEIGQDQYHQQVHHAQQQQQQQQQQQ 784

Human   447 ----PNQSDVVEAEGSHSNSPTNMAPSARLEEA-----VWRPY 480
                |.|.. ||:.|....|......|||.|:.     |||||
  Fly   785 QVHHPQQQQ-VESAGEVGGSGAGGVESAREEDVGDLSQVWRPY 826

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RUNX1	NP_001745.2	Runt	78..206	CDD:459963	95/129 (74%)
		RunxI	389..480	CDD:430037	33/166 (20%)
lz	NP_511099.2	Runt	281..404	CDD:459963	95/121 (79%)