Protein Alignment RUNX1 and rnt-1

DIOPT Version :10

• Sequence 1: NP_001745.2
• Gene: RUNX1 / 861
• HGNCID: 10471
• Length: 480
• Species: Homo sapiens
• Sequence 2: NP_001370335.1
• Gene: rnt-1 / 172243
• WormBaseID: WBGene00004393
• Length: 301
• Species: Caenorhabditis elegans
• Alignment Length: 303
• Identity: 101/303 - (33%)
• Similarity: 132/303 - (43%)
• Gaps: 68/303 - (22%)

Human    76 RSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENY 140
            |:.:|........|.::.|||.|.:.||.|||.||:....|.||.|..|||.|.|::.|||||..
 Worm     9 RNFIEQQPAPAKTLEKSSSPNILYTALPKHWRSNKSFQEPFYVVLLTPVPDNTEVSIWAGNDEKP 73

Human   141 SAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRR 205
            ..|:||..|.:..|||:|||||||||||||:.|.|||.:.:.|..|||....||:||||||:.|
 Worm    74 CEEVRNEKAKVHRQVAKFNDLRFVGRSGRGRKFHLTIVIHSAPMMVATVKNVIKVTVDGPRDAR- 137

Human   206 HRQKLDDQTKP-GSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQD 269
                   ..|| |||.     .:.||     ..:.|:....||.|           |.|.:.:
 Worm   138 -------IPKPQGSLK-----RQAEQ-----QTIFPNDIIRTPGP-----------PMPMTMI-- 172

Human   270 TRQIQPSPPW---SYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAP------ 325
                  .|||   ...|::       .||..|.  ||||....::....::.|.....|
 Worm   173 ------PPPWFPLPMTQTF-------PPSFFPL--ISPGPHPSISAALWKIHSESMKTPIKQKVE 222

Human   326 -------DLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVT 361
                   ..|..|.|..| ..|:..|.::..|.    ||..:|
 Worm   223 QENVSLNTSTCLSSPSIF-ITPTSDDRKLKRPS----SPRSIT 260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RUNX1	NP_001745.2	Runt	78..206	CDD:459963	64/127 (50%)
		RunxI	389..480	CDD:430037
rnt-1	NP_001370335.1	Runt	22..137	CDD:459963	62/114 (54%)