Protein Alignment RUNX1 and Runx1

DIOPT Version :10

• Sequence 1: NP_001745.2
• Gene: RUNX1 / 861
• HGNCID: 10471
• Length: 480
• Species: Homo sapiens
• Sequence 2: NP_001104491.1
• Gene: Runx1 / 12394
• MGIID: 99852
• Length: 465
• Species: Mus musculus
• Alignment Length: 480
• Identity: 448/480 - (93%)
• Similarity: 452/480 - (94%)
• Gaps: 15/480 - (3%)

Human     1 MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGAPDAGA 65
            |||||||||||||||||||             ||||||||||||||||||||||||||||||.||
Mouse     1 MASDSIFESFPSYPQCFMR-------------DASTSRRFTPPSTALSPGKMSEALPLGAPDGGA 52

Human    66 ALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLV 130
            |||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    53 ALASKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLV 117

Human   131 TVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKI 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   118 TVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKI 182

Human   196 TVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFN 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   183 TVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFN 247

Human   261 PQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAP 325
            |||||||||.|||||||||||||||||||||.|.|||||||||||||||||:|||||||||||||
Mouse   248 PQPQSQMQDARQIQPSPPWSYDQSYQYLGSITSSSVHPATPISPGRASGMTSLSAELSSRLSTAP 312

Human   326 DLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQ 390
            |||||.||||||.||||||||||||||||||| |||||||||||||.||:|||||||||||||||
Mouse   313 DLTAFGDPRQFPTLPSISDPRMHYPGAFTYSP-PVTSGIGIGMSAMSSASRYHTYLPPPYPGSSQ 376

Human   391 AQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPNQSDVVEA 455
            ||.||||..|||||||||||||||||||||||||||||||||||||||:||||||||:||||||.
Mouse   377 AQAGPFQTGSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGAALLNPSLPSQSDVVET 441

Human   456 EGSHSNSPTNMAPSARLEEAVWRPY 480
            ||||||||||| |.|||||||||||
Mouse   442 EGSHSNSPTNM-PPARLEEAVWRPY 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RUNX1	NP_001745.2	Runt	78..206	CDD:459963	127/127 (100%)
		RunxI	389..480	CDD:430037	82/90 (91%)
Runx1	NP_001104491.1	Runt	65..193	CDD:459963	127/127 (100%)
		RunxI	375..465	CDD:430037	82/90 (91%)