DRSC/TRiP Functional Genomics Resources

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Protein Alignment RUNX2 and run

DIOPT Version :10

Sequence 1:NP_001019801.3 Gene:RUNX2 / 860 HGNCID:10472 Length:521 Species:Homo sapiens
Sequence 2:NP_523424.2 Gene:run / 33059 FlyBaseID:FBgn0003300 Length:510 Species:Drosophila melanogaster


Alignment Length:560 Identity:173/560 - (30%)
Similarity:233/560 - (41%) Gaps:173/560 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    71 QEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPA------------------------ 111
            |..|||||||||||||.|..|..: ...|.|....||.:||                        
  Fly    15 QVLAAAAAAAAAAAAAVAQGPGPQ-QSSNATTASAIAINPAQSLANTSTHSASSTGSSTPDLSTN 78

Human   112 --------------------------------------ELVRTDSPNFLCSVLPSHWRCNKTLPV 138
                                                  ||.:|.||:.|||.||:|||.||:||.
  Fly    79 NTSSSSNATTSPQNSAKMPSSMTDMFASLHEMLQEYHGELAQTGSPSILCSALPNHWRSNKSLPG 143

Human   139 AFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITV 203
            ||||:||.:|||||:|::..||||||..||||.:..||||||:|||||||||||||||||||||:
  Fly   144 AFKVIALDDVPDGTLVSIKCGNDENYCGELRNCTTTMKNQVAKFNDLRFVGRSGRGKSFTLTITI 208

Human   204 FTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDSKPSLFSDRLSDLGRIPHPSMRVGVPPQNPRP 268
            .|.|.|:|:|.:|||||||||||||        ||.|.         ..||              
  Fly   209 ATYPVQIASYSKAIKVTVDGPREPR--------SKQSY---------GYPH-------------- 242

Human   269 SLNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSY---------------------LSQMTS 312
                 |..|||           ...:|.| .|.:|.:|                     |::.::
  Fly   243 -----PGAFNP-----------FMLNPAW-LDAAYMTYGYADYFRHQAAAQAAQVHHPALAKSSA 290

Human   313 PSIHSTTPLSSTRGTGLPAITDVPRRISDDDTATSDFCLWPSTLSKKSQAGASELGPFSDPRQFP 377
            .|: |..|..|...:...|:.  |........|.:.....|:.: ..|..||:...|::.| |||
  Fly   291 SSV-SPNPNPSVATSSSSAVQ--PSEYPHPAAAVAAAAGQPAAM-MPSPPGAAPATPYAIP-QFP 350

Human   378 --SISSLTESRFSNPRMHYPATFTYTPPVTSGMSLGMSATTHYHTYLPPPYPGSSQ-SQSGPFQ- 438
              .:::...::.:.|...:|..|.    ..:|:. ..:|..|:.:......|.||: |.|.|.| 
  Fly   351 FNHVAAAAAAKAATPHAFHPYNFA----AAAGLR-ARNAALHHQSEPVHVSPASSRPSSSSPTQQ 410

Human   439 -------TS-STPYLYYGTSSG-----------SYQFPMVPGGDRSPSRMLPPCTTTSNGSTLLN 484
                   || .|..::..::|.           ..:|.:....|.:|.||  .|..  ...:.:.
  Fly   411 HVLLKLNTSIETSSIHEQSASDGDSDDEQIDVVKSEFDLDKSLDVAPLRM--RCDL--KAPSAMK 471

Human   485 PNLPNQNDGVDADGSHSSSP---TVLNSSGRMDESVWRPY 521
            |.......|..|: |...||   |.:.|:....::|||||
  Fly   472 PLYHESGPGAVAN-SRQPSPETTTKIKSAAVQQKTVWRPY 510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RUNX2NP_001019801.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 18..59
polyglutamine repeat 49..71 173/560 (31%)
polyalanine repeat 73..89 13/15 (87%)
Runt 102..230 CDD:459963 88/189 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 222..340 28/138 (20%)
Required for interaction with FOXO1. /evidence=ECO:0000250 242..258 2/15 (13%)
Herpes_BLLF1 <266..481 CDD:282904 49/258 (19%)
Interaction with KAT6A. /evidence=ECO:0000250 336..439 24/113 (21%)
Interaction with KAT6B. /evidence=ECO:0000269|PubMed:11965546 374..468 23/116 (20%)
RunxI 430..521 CDD:430037 26/114 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 460..521 16/63 (25%)
runNP_523424.2 Runt 107..235 CDD:459963 84/135 (62%)
Blue background indicates that the domain is not in the aligned region.

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