Sequence 1: | NP_001019801.3 | Gene: | RUNX2 / 860 | HGNCID: | 10472 | Length: | 521 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_511099.2 | Gene: | lz / 31883 | FlyBaseID: | FBgn0002576 | Length: | 826 | Species: | Drosophila melanogaster |
Alignment Length: | 441 | Identity: | 143/441 - (32%) |
---|---|---|---|
Similarity: | 197/441 - (44%) | Gaps: | 137/441 - (31%) |
- Green bases have known domain annotations that are detailed below.
Human 108 DHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNAS 172
Human 173 AVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDS 237
Human 238 KPSLFSDRLSDLGRIPHPSMRVGVPPQNPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQS 302
Human 303 YPSYLSQMTSPSIHSTTPLSSTR---------------------------GTGLPAITDVPRRIS 340
Human 341 D-DDTATSDFCLW-PST--LSKKSQAGASELGPFSDPRQFPSISSLTESRFSNPRMHYPAT---- 397
Human 398 ------FTYTPP-----------------VTSGMSLGM--------------SATT----HYHTY 421
Human 422 LP---PPYPGSSQSQSGPFQTSSTPYLYYGTSSGSYQFPMVPGGDRSPSRM 469 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
RUNX2 | NP_001019801.3 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 18..59 | ||
polyglutamine repeat | 49..71 | ||||
polyalanine repeat | 73..89 | ||||
Runt | 109..230 | CDD:307137 | 95/120 (79%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 222..340 | 20/144 (14%) | |||
Required for interaction with FOXO1. /evidence=ECO:0000250 | 242..258 | 2/15 (13%) | |||
Herpes_BLLF1 | <266..481 | CDD:330317 | 45/283 (16%) | ||
Interaction with KAT6A. /evidence=ECO:0000250 | 336..439 | 26/154 (17%) | |||
Interaction with KAT6B. /evidence=ECO:0000269|PubMed:11965546 | 374..468 | 26/141 (18%) | |||
RunxI | 430..521 | CDD:312115 | 10/40 (25%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 460..521 | 4/10 (40%) | |||
lz | NP_511099.2 | Runt | 283..404 | CDD:279225 | 95/135 (70%) |
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 0 | 0.000 | Not matched by this tool. | |||
Hieranoid | 1 | 1.000 | - | - | ||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S5786 |
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 1 | 1.000 | - | - | FOG0000993 | |
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 1 | 1.100 | - | - | O | PTHR11950 |
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 1 | 1.000 | - | - | X738 | |
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
6 | 5.960 |