DRSC/TRiP Functional Genomics Resources

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Protein Alignment ACTL6A and Act88F

DIOPT Version :10

Sequence 1:NP_004292.1 Gene:ACTL6A / 86 HGNCID:24124 Length:429 Species:Homo sapiens
Sequence 2:NP_524367.1 Gene:Act88F / 41885 FlyBaseID:FBgn0000047 Length:376 Species:Drosophila melanogaster


Alignment Length:423 Identity:154/423 - (36%)
Similarity:229/423 - (54%) Gaps:54/423 - (12%)


- Green bases have known domain annotations that are detailed below.


Human     9 DEVGALVFDIGSYTVRAGYAGEDCPKVDFPTAIGMVVERDDGSTLMEIDGDKGKQGGPTYYIDTN 73
            |:.||||.|.||...:||:||:|.|:..||:.:|.  .|..|  :|...|.|..      |:...
  Fly     4 DDAGALVIDNGSGMCKAGFAGDDAPRAVFPSIVGR--PRHQG--VMVGMGQKDS------YVGDE 58

Human    74 ALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPVLMSEAPWNTRAKREKLTE 138
            | :..|..:....|:::|::.:||..:.|..||:...::.....||||::|||.|.:|.|||:|:
  Fly    59 A-QSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQ 122

Human   139 LMFEHYNIPAFFLCKTAVLTAFANGRSTGLILDS--GATHTTAIPVHDGYVLQQGIVKSPLAGDF 201
            :|||.:|.||.::...|||:.:|:||:||::|||  |.:||  :|:::|:.|...|::..|||..
  Fly   123 IMFETFNSPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHT--VPIYEGFALPHAILRLDLAGRD 185

Human   202 ITMQCRELFQEMNIELVPPYMIASKEAVREGSPANWKRKEKLPQVTRSWHNYMCNC-VIQDFQAS 265
            :|....::..|......   ..|.:|.||:       .||||             | |..||:..
  Fly   186 LTDYLMKILTERGYSFT---TTAEREIVRD-------IKEKL-------------CYVALDFEQE 227

Human   266 VLQVSDSTYDEQVAAQMPTVHYEFPNGYNCDFGAERLKIPEGLFDPSNVKGLSGNTMLGVSHVVT 330
            :...:.||..|:        .||.|:|.....|.||.:.||.||.||    ..|....|:...|.
  Fly   228 MATAAASTSLEK--------SYELPDGQVITIGNERFRCPEALFQPS----FLGMESCGIHETVY 280

Human   331 TSVGMCDIDIRPGLYGSVIVAGGNTLIQSFTDRLNRELSQKTPPSMRLKLIANNTTVERRFSSWI 395
            .|:..||:|||..||.:.:::||.|:.....||:.:|::...|.::::|:||   ..||::|.||
  Fly   281 NSIMKCDVDIRKDLYANSVLSGGTTMYPGIADRMQKEITALAPSTIKIKIIA---PPERKYSVWI 342

Human   396 GGSILASLGTFQQMWISKQEYEEGGKQCVERKC 428
            ||||||||.||||||||||||:|.|...|.|||
  Fly   343 GGSILASLSTFQQMWISKQEYDESGPGIVHRKC 375

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACTL6ANP_004292.1 ASKHA_NBD_Arp4_ACTL6-like 8..420 CDD:466846 149/413 (36%)
Act88FNP_524367.1 ASKHA_NBD_actin 8..371 CDD:466823 148/413 (36%)

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