DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCARF1 and scarf1

DIOPT Version :9

Sequence 1:	NP_003684.2	Gene:	SCARF1 / 8578	HGNCID:	16820	Length:	830	Species:	Homo sapiens
Sequence 2:	XP_001344375.3	Gene:	scarf1 / 100005273	ZFINID:	ZDB-GENE-030131-8778	Length:	888	Species:	Danio rerio

Alignment Length:	896	Identity:	375/896 - (41%)
Similarity:	502/896 - (56%)	Gaps:	105/896 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    10 LLLWTRGTQGSELDPKGQHVCVASSPSAELQCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGL 74
            |:|.........|...|::||::...|:.: ||:||.|...|||:|:|||..||.:|||||.|||
Zfish    10 LMLMCVQYSAQRLSLTGKNVCLSVRDSSAI-CCSGWGQSGDECTVPLCEGERACLQDEVCVYPGL 73

Human    75 CRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHG 139
            ||||.||:|..|.:.||.::|||||||.|||||||.|:||||.|.|..:|||:.|:..|.||.||
Zfish    74 CRCKAGFYGYQCKAPCPPEFWGPDCREFCPCHPHGLCDPATGVCSCLPNRWGSLCQNSCKCGRHG 138

Human   140 RCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGSPCEQD 204
            :|||..|.|.||.|||:|||.:.|||:.|.:.|:||||.|:|..|:||::||..|||:.|||:|.
Zfish   139 KCDPVYGNCTCEEGWWTSTCSKACQCHLATSTCDQATGRCICNEGYWGQKCSLPCNCYVSPCQQR 203

Human   205 SGRCACRPGWWGPECQQQCEC--VRGRCSAASGECTCPPGFRGARCELPCPAGSHGVQCAHSCGR 267
            :|.|.|..|||||.|.::|.|  ....|...:|.|.|.||::...|..||.:|.:|..|.:||||
Zfish   204 TGTCQCLHGWWGPSCDRRCICNLNNADCDVQTGGCLCYPGYKEPFCNEPCDSGKYGRGCKNSCGR 268

Human   268 CKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPG 332
            |:...|||...|.|::||||||||:|.|.|..|.:|..|::.|||||:.:.|:|:||.|.:|:||
Zfish   269 CEGGRPCSKLDGLCDACEPGWNGTRCDQRCPAGYYGHRCQEICPHCRNMDPCDPETGACLQCNPG 333

Human   333 WLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVP 397
            |.||||:.||..|.:|:.|...|.||..|.||.|||.|:|..|:.|.|||::||...:|.|||..
Zfish   334 WTGPRCDKPCTDGRYGDGCRFLCKTCNHGHCDHVTGRCICLPGFQGESCNSTCPFNLYGFNCSST 398

Human   398 CECPEGLCHPVSGSCQPGSGSRDTALIAGSLVPLLLLFLGLACCACCCWAPRSDLKDRPARDGAT 462
            |:|....|||.:|:| |.| || ..|:||.|:||.:|.|.|..|.|||..|....:.....||:.
Zfish   399 CDCGSQACHPATGAC-PNS-SR-AGLLAGLLIPLCILILALLFCCCCCGRPVEGKERVTVGDGSP 460

Human   463 VSRMKLQVWGTLTSLGSTLPCRSLSSHKLPWVTVSHHDPEVPFNHSFIEPPSAGWATDDSFSSDP 527
            ..|||..|:..|.::||.:||.:|.|..||.|||||||||:.|||||||.||:||.. |||.:|
Zfish   461 AVRMKHHVYTVLANMGSAMPCITLWSSGLPRVTVSHHDPELTFNHSFIEQPSSGWVI-DSFETD- 523

Human   528 ESGEADEVPAYCVPPQEGMVPVAQAGSSEASLAAGAFPPP-----EDASTPFAIPRTSSLARAKR 587
            |.|||    .||.||:|.::..|.....|.:.....||.|     ||.|..|.||||||:|::||
Zfish   524 EDGEA----VYCEPPREDVLTEAGGELQELNSKCNFFPDPSTFSSEDMSQAFGIPRTSSIAKSKR 584

Human   588 PSVSFAEGTKFAPQSRRSS-GELSSPLRKPK----------RLSRGAQSGPEGREAEESTGPEEA 641
            |||||||||||:|:.|||| .:|....||||          :..:|.|:.....|.||....|..
Zfish   585 PSVSFAEGTKFSPKERRSSTQDLQGTARKPKPWGVLMISALQGGQGNQNNETETEKEEKNDEENI 649

Human   642 EAPESFPAAASPGDS---ATGHRRPPL---GG--RTVA---EHVEAIEGSVQESSGPVTTIYMLA 695
            ...:...:.....||   ::|.:|..|   ||  ||::   :::::.:|.....|..:||:|:..
Zfish   650 SEEQRASSETLQNDSERYSSGPQRTHLTVPGGRRRTLSNPKKNIQSSDGGQDADSEKLTTVYVTV 714

Human   696 GKPR-------GSEGPVRSVFRHFGSFQKGQAE-AKVK-RAIPKPPRQALNRKKGSPGLASGSVG 751
            ||..       .|||||:::.|..||.|:.:.| ||.| ::|.||||:.|..:..:...|||| |
Zfish   715 GKTSKMVKQEPPSEGPVQAMLRRLGSLQRQKEEVAKGKAQSIVKPPRRKLGARASAWEQASGS-G 778

Human   752 QS------PNSAPKAGLPGATGPMAVRPEEAVRGLGAGTESSRRAQEPVSGC--GSPEQDPQKQA 808
            ||      |:....:.|   :.|..|       |.....:.:...:.|:|..  ..||.||.:..
Zfish   779 QSEVVMRKPSRKKHSSL---SSPCIV-------GAIDSPQENSAPKRPLSSILKSVPESDPFQSL 833

Human   809 E--------------------------------------EERQEEPEYENV 821
            |                                      ::.:.||.||||
Zfish   834 EVEPNSEETGIQTEHTYETVALPDTVSTSSEIIINDTVMDQAENEPNYENV 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCARF1	NP_003684.2	CSRNP_N	<100..135	CDD:292638	21/34 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..539		10/22 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..688		42/128 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..830		36/155 (23%)
scarf1	XP_001344375.3	EGF_CA	361..401	CDD:304395	20/39 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194344421
Domainoid	1	1.000	441	1.000	Domainoid score	I3744
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2741
Inparanoid	1	1.050	734	1.000	Inparanoid score	I3988
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG42407
OrthoDB	1	1.010	-	-		D110992at2759
OrthoFinder	1	1.000	-	-		FOG0010718
OrthoInspector	1	1.000	-	-		oto46583
orthoMCL	1	0.900	-	-		OOG6_122018
Panther	1	1.100	-	-	LDO	PTHR24043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X8220
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.410