Protein Alignment CASK and CASK

DIOPT Version :10

• Sequence 1: NP_001354650.1
• Gene: CASK / 8573
• HGNCID: 1497
• Length: 926
• Species: Homo sapiens
• Sequence 2: NP_001262811.1
• Gene: CASK / 42567
• FlyBaseID: FBgn0013759
• Length: 929
• Species: Drosophila melanogaster
• Alignment Length: 947
• Identity: 574/947 - (60%)
• Similarity: 710/947 - (74%)
• Gaps: 70/947 - (7%)

Human     1 MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASI 65
            |.:|::||:|||||||||||||||:|||||:||:.||||||||||||||:||||||.||||||:|
  Fly     1 MTEDEILFDDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATI 65

Human    66 CHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALR 130
            ||||||||||||||||||:||||||||||:|:|||||:|:||.||||||||||.|||||||||||
  Fly    66 CHMLKHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALR 130

Human   131 YCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQL--GESGLVAGGRVGTPHFMAPEVVKR 193
            |||:|:|:||||:|.|.|||:.:|||||||||||.||||  ....:...||||.||:||||||.|
  Fly   131 YCHENDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTR 195

Human   194 EPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLM 258
            ..|||..||||.||:|.:||||.|||.|:..||.:.:.:|:......:|..||.:|||||.:||.
  Fly   196 RLYGKGCDVWGAGVMLHVLLSGRLPFLGSGVRLQQSVARGRLSFEAPEWKSISANAKDLVMKMLA 260

Human   259 LDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFY-- 321
            .:|..|:::.|.|:|||:::||: ..:.||.:|||:|:::||||||||||.|.......:..|
  Fly   261 ANPHHRLSITEVLDHPWIRDRDK-LQRTHLADTVEELKRYNARRKLKGAVQAIAGGTNMDPLYAT 324

Human   322 -GDPP-----EELPDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHL 380
             .|.|     :|..|  |:       |...||.::||.|::|::|.| :..|.|.|..:.:|..|
  Fly   325 DADMPITGATDEWAD--EE-------AGIEAVQRILDCLDDIYSLQD-AHVDADVLRDMLRDNRL 379

Human   381 HTLLDLYDKI-NTKSSPQIRNPPSDAVQRAKEVLEEISCYPENND------AKELKRILTQPHFM 438
            |..|.|:|:| .|..:...|.|.::||.|.::|||::|.....|.      .:||.|:|..||..
  Fly   380 HQFLQLFDRIAATVVTSNGRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQ 444

Human   439 ALLQTHDVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGI 503
            |||.:|||||.:||.:|||||||||..||||||..::..|. ::::|||||||||||||||||||
  Fly   445 ALLHSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNVEGG-ELQHVTRVRLVQFQKNTDEPMGI 508

Human   504 TLKMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIV 568
            ||||.|...|||||||||||||||.|||||||||||||..|.:|:|.|||:||||.|||:|||||
  Fly   509 TLKMTEDGRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIV 573

Human   569 PSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPC 633
            ||||:....||                                   |:|||||:|:|..|:||||
  Fly   574 PSYRSAPPPCE-----------------------------------IFVRAQFDYNPLDDELIPC 603

Human   634 KEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASC 698
            .:|||.|:||||:||||||||:|||.:|: :..|:|||||||||||||:||..::||||| |.:|
  Fly   604 AQAGISFQVGDILQIISKDDHHWWQARLD-TVGGSAGLIPSPELQEWRIACQTVDKTKQE-QVNC 666

Human   699 TWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPA----FKRKTLVLLGAHGVGRRHIKNTL 759
            :.||:||||.:|||||||||:||.||:||||||||:|.    |:|||||||||||||||||||||
  Fly   667 SIFGRKKKQCRDKYLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKTLVLLGAHGVGRRHIKNTL 731

Human   760 ITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIR 824
            |:|:||::||||||||||.|.:||||::|||||||:||.||..|||||||:||||||||||:|||
  Fly   732 ISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTHEDAMYGTKLDTIR 796

Human   825 KIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHY 889
            :||.:|.:|||||||||||:||||||.|:|||||||::....:.|.||:||.|||::|::.|.|:
  Fly   797 RIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIADYDGSLERLAKESEMLRQLYGHF 861

Human   890 FDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY 926
            |||||:||:|.|||..||.|::.|.|.||||||||:|
  Fly   862 FDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWLY 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001354650.1	STKc_CASK	8..307	CDD:270996	203/300 (68%)
		Calmodulin-binding	305..315		5/9 (56%)
		L27	348..401	CDD:197794	18/53 (34%)
		L27	406..456	CDD:460717	23/55 (42%)
		Required for interaction with NRXN1 (via C-terminal tail). /evidence=ECO:0000250|UniProtKB:Q62915	482..909		284/430 (66%)
		PDZ_CASK-like	489..569	CDD:467267	65/79 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	574..610		2/35 (6%)
		SH3_CASK	616..677	CDD:213014	40/60 (67%)
		Guanylate_kin	738..911	CDD:395500	124/172 (72%)
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	204/301 (68%)
		L27	347..396	CDD:460717	18/49 (37%)
		L27	406..462	CDD:460717	29/61 (48%)
		PDZ_CASK-like	494..574	CDD:467267	65/79 (82%)
		SH3_CASK	586..646	CDD:213014	20/59 (34%)
		Guanylate_kin	710..883	CDD:395500	130/176 (74%)