DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CASK and lin-2

DIOPT Version :10

Sequence 1:NP_001354650.1 Gene:CASK / 8573 HGNCID:1497 Length:926 Species:Homo sapiens
Sequence 2:NP_001024587.1 Gene:lin-2 / 181400 WormBaseID:WBGene00002991 Length:961 Species:Caenorhabditis elegans


Alignment Length:998 Identity:468/998 - (46%)
Similarity:635/998 - (63%) Gaps:118/998 - (11%)


- Green bases have known domain annotations that are detailed below.


Human     3 DDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICH 67
            :.::|.::...:.:||.:||||.|.|.::..:.::|.::.:::..|....||..|::..|..||.
 Worm     8 ESNLLLDEQLSIRDVIEQGPFSNVYRILHGPSNRKFLLRSINLNLFRQHTGLGFEEIDEEIRICQ 72

Human    68 MLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYC 132
            .|:||:|..|.:|.:|....:::||.|:|.|:|||||:||..|||:||.|.|||.||:|:||.||
 Worm    73 NLQHPYICRLEKTINSVHYRHIIFENMEGNDICFEIVQRASNGFVFSEYVVSHYTRQLLDALDYC 137

Human   133 HDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGE-SGLVAGGRVGTPHFMAPEVVKREPY 196
            |...|:||||:||.::||||:.|||:||.|||||..|.| .|.:|.||||.|.|||||:|:::..
 Worm   138 HTRKIVHRDVRPHNLVLASKDTSAPLKLCGFGVAKDLSEIGGSMACGRVGVPQFMAPEIVRKDRV 202

Human   197 GKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDP 261
            ....|:|..||:||:||:|.|||.|:...::|.|::....:: ....:|||||::||||||..||
 Worm   203 SCSSDIWSSGVVLFLLLAGRLPFSGSTSDIYERIMQTDVDVD-GYMPNISESARNLVRRMLNADP 266

Human   262 AERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPE 326
            ::||:..|||||.|:::::..|.:.|:.:.::|:|::|..||||..||:||:|.:|:.  ..|.:
 Worm   267 SKRISAKEALNHEWIRDKEHMASRKHMNDVIDQMRRYNESRKLKSNVLSAVNSGRFDE--TTPRQ 329

Human   327 ELP-----------------------DFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCS--EK 366
            :.|                       |.:|.|....|..|.:    ||.||:.|::|.|.:  :.
 Worm   330 DTPQTAFVDGSSPGGDCCHRGESSSNDAAEPPADKDLSGAYK----VLGSLDAINSLLDPNSYKP 390

Human   367 DLDFLHSVFQDQHLHTLLDLYDKINT-KSSPQIRNPPSDAVQRAKEVLEEI-SCYPENNDAKELK 429
            .......:..|..:..||.|||||.. ...|.:....:..::  ||.|.:| .....:.:|.||:
 Worm   391 GSTTFQKIHDDGSVRNLLRLYDKIKALPCEPVVTEVDTSTLR--KETLNQIDGLLGPSPEALELR 453

Human   430 RILTQPHFMALLQTHDVVAHEVY----------SDEALRVTPPPTSPYLNG-------------- 470
            ::|..||..:.:|..|||..|:.          ..|...|:..|...||||              
 Worm   454 QLLNSPHLASCVQALDVVVCEIRDPKNEASGSGDKEGNCVSSDPAPAYLNGGVLPLGAQRAGTSF 518

Human   471 ----DSPESANGDMDMEN----VTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHRQ 527
                .|....:.|.:.|.    ::|:|||||||:|.||||||||:||...|.|||||||||||||
 Worm   519 EHFNQSAVHTSYDEEEEELYDCMSRLRLVQFQKDTQEPMGITLKVNEDGRCFVARIMHGGMIHRQ 583

Human   528 GTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPAN 592
            .|||||||||||||:||||::||.||:|||:.||.:||||:||||:...:||             
 Worm   584 ATLHVGDEIREINGMSVANRSVESLQEMLRDARGQVTFKIIPSYRSAPPACE------------- 635

Human   593 GHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWW 657
                                  |:|||||:|:|::||||||.:|||.|:.|||:|:|||||||||
 Worm   636 ----------------------IFVRAQFDYEPSQDDLIPCPQAGIPFKTGDILQVISKDDHNWW 678

Human   658 QGK-------LENSKNG-------TAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQY 708
            |.:       :.||.|.       .|||||||||||||.||:|||::|......|.||.||||.|
 Worm   679 QARFVSSFPSIGNSSNAQRSNQQQVAGLIPSPELQEWRTACLAMERSKNTCNTHCMWFNKKKKYY 743

Human   709 KDKYLAKHNAVFDQLDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPH 773
            ..|||.||:|:||||||||||||::|..::||||||||||||||||||||||.:||:||||||||
 Worm   744 TTKYLQKHSALFDQLDLVTYEEVMRLSQYRRKTLVLLGAHGVGRRHIKNTLIHRHPNRFAYPIPH 808

Human   774 TTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVE 838
            |||||:|||.:||:||||:::|||.||.||||||||:||::||||||||||.||:.|.|||||||
 Worm   809 TTRPPRKDEVDGKHYYFVTNEQMMADIQNNEYLEYGTHEESMYGTKLETIRNIHKSGKIAILDVE 873

Human   839 PQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIINNEIDETI 903
            |||||||||||::|||||||||.:....:.|.||::|..|||:|::.:.|.||..|.|::||:||
 Worm   874 PQALKVLRTAEYSPFVVFIAAPNLQGMQDPDGSLEKLLNESDVLRQAFGHLFDFIITNSDIDDTI 938

Human   904 RHLEEAVELVCTAPQWVPVSWVY 926
            ..||..||.:...|||:||:|||
 Worm   939 AQLERLVEKLPAYPQWLPVTWVY 961

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CASKNP_001354650.1 STKc_CASK 8..307 CDD:270996 133/299 (44%)
Calmodulin-binding 305..315 5/9 (56%)
L27 348..401 CDD:197794 16/55 (29%)
L27 406..456 CDD:460717 15/60 (25%)
Required for interaction with NRXN1 (via C-terminal tail). /evidence=ECO:0000250|UniProtKB:Q62915 482..909 271/444 (61%)
PDZ_CASK-like 489..569 CDD:467267 62/79 (78%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..610 2/35 (6%)
SH3_CASK 616..677 CDD:213014 41/74 (55%)
Guanylate_kin 738..911 CDD:395500 120/172 (70%)
lin-2NP_001024587.1 Protein Kinases, catalytic domain 13..312 CDD:473864 133/299 (44%)
L27 374..425 CDD:197794 14/50 (28%)
L27 430..478 CDD:197794 15/49 (31%)
PDZ_CASK-like 545..625 CDD:467267 62/79 (78%)
SH3_MPP1-like 637..712 CDD:212968 41/74 (55%)
Guanylate_kin 773..948 CDD:395500 122/174 (70%)

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